Literature DB >> 36107859

Drug discovery research in Ghana, challenges, current efforts, and the way forward.

Richard Kwamla Amewu1, Patrick Amoateng2, Patrick Kobina Arthur3, Prince Asare4, Isaac Asiamah5, Daniel Boamah6, Isaac Darko Otchere4, Cedric Dzidzor Amengor7, Edmund Ekuadzi8, Kelly Chibale9, Susan Jane Farrell10, Regina Appiah-Oppong11, Dorcas Osei-Safo1, Kevin David Read10, Ian Hugh Gilbert10, Dorothy Yeboah-Manu4.   

Abstract

We have a long-term vision to develop drug discovery research capacity within Ghana, to tackle unmet medical needs in Ghana and the wider West African region. However, there are several issues and challenges that need to be overcome to enable this vision, including training, human resource, equipment, infrastructure, procurement, and logistics. We discuss these challenges from the context of Ghana in this review. An important development is the universities and research centres within Ghana working together to address some of these challenges. Therefore, while there is a long way to go to fully accomplish our vision, there are encouraging signs.

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Year:  2022        PMID: 36107859      PMCID: PMC9477258          DOI: 10.1371/journal.pntd.0010645

Source DB:  PubMed          Journal:  PLoS Negl Trop Dis        ISSN: 1935-2727


  11 in total

1.  In vitro Anti-Mycobacterium ulcerans and cytotoxic activities of some selected medicinal plants and an indoloquinoline alkaloid.

Authors:  Isaac Kingsley Amponsah; Philip Kobla Atchoglo; Raphael Yaw Ackah; Patrick Valere Tsouh Fokou; Samuel Yaw Aboagye; Dorothy Yeboah-Manu; Regina Appiah-Opong; Abraham Yeboah Mensah
Journal:  Int J Mycobacteriol       Date:  2021 Jan-Mar

2.  Medicinal Chemistry Out of Africa.

Authors:  Kelly Chibale; Kathryn J Wicht; John G Woodland
Journal:  J Med Chem       Date:  2021-07-23       Impact factor: 7.446

3.  Discovery of a Single Monooxygenase that Catalyzes Carbamate Formation and Ring Contraction in the Biosynthesis of the Legonmycins.

Authors:  Sheng Huang; Jioji Tabudravu; Somayah S Elsayed; Jeanne Travert; Doe Peace; Ming Him Tong; Kwaku Kyeremeh; Sharon M Kelly; Laurent Trembleau; Rainer Ebel; Marcel Jaspars; Yi Yu; Hai Deng
Journal:  Angew Chem Int Ed Engl       Date:  2015-07-17       Impact factor: 15.336

4.  Prenylated 2-arylbenzofuran derivatives with potent antioxidant properties from Chlorophora regia (Moraceae).

Authors:  James Oppong Kyekyeku; Souvik Kusari; Reimmel Kwame Adosraku; Sebastian Zühlke; Michael Spiteller
Journal:  Fitoterapia       Date:  2015-11-17       Impact factor: 2.882

5.  Bi- and bisbibenzyls from the roots of Dichapetalum heudelotii and their antiproliferative activities.

Authors:  Dorcas Osei-Safo; Godwin Akpeko Dziwornu; Antonio Salgado; Suthananda Naidu Sunassee; Mary Anti Chama
Journal:  Fitoterapia       Date:  2017-09-04       Impact factor: 2.882

6.  Flavonoid glycosides from the stem bark of Margaritaria discoidea demonstrate antibacterial and free radical scavenging activities.

Authors:  Edmund Ekuadzi; Rita Dickson; Theophilus Fleischer; Kofi Annan; Dominik Pistorius; Lukas Oberer; Simon Gibbons
Journal:  Phytother Res       Date:  2013-08-22       Impact factor: 5.878

7.  Constituents of the Roots of Dichapetalum pallidum and Their Anti-Proliferative Activity.

Authors:  Dorcas Osei-Safo; Godwin Akpeko Dziwornu; Regina Appiah-Opong; Mary Anti Chama; Isaac Tuffour; Reiner Waibel; Richard Amewu; Ivan Addae-Mensah
Journal:  Molecules       Date:  2017-03-27       Impact factor: 4.411

8.  Antischistosomal, antionchocercal and antitrypanosomal potentials of some Ghanaian traditional medicines and their constituents.

Authors:  Emmanuella Bema Twumasi; Pearl Ihuoma Akazue; Kwaku Kyeremeh; Theresa Manful Gwira; Jennifer Keiser; Fidelis Cho-Ngwa; Adrian Flint; Barbara Anibea; Emmanuel Yeboah Bonsu; Richard K Amewu; Linda Eva Amoah; Regina Appiah-Opong; Dorcas Osei-Safo
Journal:  PLoS Negl Trop Dis       Date:  2020-12-31

9.  Discovery of New Antibacterial Accramycins from a Genetic Variant of the Soil Bacterium, Streptomyces sp. MA37.

Authors:  Fleurdeliz Maglangit; Yuting Zhang; Kwaku Kyeremeh; Hai Deng
Journal:  Biomolecules       Date:  2020-10-20

10.  Chemical Derivatization and Characterization of Novel Antitrypanosomals for African Trypanosomiasis.

Authors:  Aboagye Kwarteng Dofuor; Temitayo Samson Ademolue; Cynthia Mmalebna Amisigo; Kwaku Kyeremeh; Theresa Manful Gwira
Journal:  Molecules       Date:  2021-07-25       Impact factor: 4.411

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