Kevin A Cross1, Afshin Salehi2, Mohamed S Abdelbaki3, David H Gutmann4, David D Limbrick5. 1. Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO, USA. 2. Division of Pediatric Neurosurgery, Department of Neurological Surgery, University of Nebraska Medical Center, Omaha Children's Hospital Medical Center, Omaha, NE, USA. 3. Division of Hematology and Oncology, Department of Pediatrics, St. Louis Children's Hospital, Washington University School of Medicine, St. Louis, MO, USA. 4. Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA. 5. Division of Pediatric Neurosurgery, Department of Neurological Surgery, St. Louis Children's Hospital, Washington University School of Medicine, St. Louis, MO, USA. limbrickd@wustl.edu.
Abstract
PURPOSE: Nearly a quarter of neurofibromatosis type 1 (NF 1)- associated diencephalic low-grade tumors are refractory to chemotherapy. Addition of alternative treatment options with laser interstitial thermal therapy will have a positive impact on the outcome of these patients. METHODS: We report on two illustrated cases of pediatric NF1- associated, chemoresistant, WHO grade 1 pilocytic astrocytomas treated with laser interstitial thermal therapy (LITT). RESULTS: Both tumors responded favorably to LITT. CONCLUSION: LITT should be considered as a treatment option for chemoresistant deep-seated NF1-associated low-grade gliomas.
PURPOSE: Nearly a quarter of neurofibromatosis type 1 (NF 1)- associated diencephalic low-grade tumors are refractory to chemotherapy. Addition of alternative treatment options with laser interstitial thermal therapy will have a positive impact on the outcome of these patients. METHODS: We report on two illustrated cases of pediatric NF1- associated, chemoresistant, WHO grade 1 pilocytic astrocytomas treated with laser interstitial thermal therapy (LITT). RESULTS: Both tumors responded favorably to LITT. CONCLUSION: LITT should be considered as a treatment option for chemoresistant deep-seated NF1-associated low-grade gliomas.
Authors: Saba Sharif; Rosalie Ferner; Jillian M Birch; James E Gillespie; H Rao Gattamaneni; Michael E Baser; D Gareth R Evans Journal: J Clin Oncol Date: 2006-06-01 Impact factor: 44.544
Authors: Elina Uusitalo; Matti Rantanen; Roope A Kallionpää; Minna Pöyhönen; Jussi Leppävirta; Heli Ylä-Outinen; Vincent M Riccardi; Eero Pukkala; Janne Pitkäniemi; Sirkku Peltonen; Juha Peltonen Journal: J Clin Oncol Date: 2016-02-29 Impact factor: 44.544
Authors: Jasia Mahdi; Amish C Shah; Aimee Sato; Stephanie M Morris; Robert C McKinstry; Robert Listernick; Roger J Packer; Michael J Fisher; David H Gutmann Journal: Neurology Date: 2017-03-22 Impact factor: 9.910
Authors: R J Packer; J Ater; J Allen; P Phillips; R Geyer; H S Nicholson; R Jakacki; E Kurczynski; M Needle; J Finlay; G Reaman; J M Boyett Journal: J Neurosurg Date: 1997-05 Impact factor: 5.115
Authors: Paul Steinbok; Chittur Viswanathan Gopalakrishnan; Alexander R Hengel; Aleksander M Vitali; Ken Poskitt; Cynthia Hawkins; James Drake; Maria Lamberti-Pasculli; Olufemi Ajani; Walter Hader; Vivek Mehta; P Daniel McNeely; Patrick J McDonald; Adrianna Ranger; Michael Vassilyadi; Jeff Atkinson; Scott Ryall; David D Eisenstat; Juliette Hukin Journal: Childs Nerv Syst Date: 2015-11-23 Impact factor: 1.475