Dan Ye1, Haoran Shen1, Wu Huang1, Liangqing Yao1. 1. Gynecology Department, Obstetrics and Gynecology Hospital of Fudan University No. 419 Fangxie Road, Shanghai 200090, P. R. China.
Abstract
OBJECTIVES: Since patients with borderline ovarian tumors (BOTs) are relatively young with good survival rates, conservative surgery is prioritized as a therapeutic intervention. However, the high recurrence rate of this tumor remains an issue that demands further attention. In addition, it is unclear whether the increment of recurrent risk is attributed to conservative surgery or staging surgery. This study was designed to analyze the relapse-related factors of BOTs. METHODS: This retrospective cohort study was comprised of 74 patients with BOTs who underwent surgery at the Obstetrics and Gynecology Hospital of Fudan University from September 2014 to September 2017. The recurrence-free survival (RFS) rate was calculated using the Kaplan-Meier method, while the risk factors of RFS were evaluated using Cox-regression analysis. RESULTS: The 3-year RFS was 2.7% with a median follow-up duration of 45 months (range: 28-62). Kaplan-Meier analysis indicated that low tumor node metastasis (TNM) stage (P = 0.005), lymphadenectomy (P = 0.052) and fertility-preservation surgery (P = 0.059) were the factors that may lower recurrence. Meanwhile, Cox-regression showed that only low TNM stage was significantly associated with a better RFS (P = 0.005). CONCLUSIONS: With the removal of visible lesions by standard surgery, patients at TNM stage I had a better RFS. Fertility-preservation surgery did not increase the recurrence risk. For bilateral ovarian cyst however, it was unclear whether bilateral cystectomy can increase the recurrence risk. Therefore, further study is required. AJTR
OBJECTIVES: Since patients with borderline ovarian tumors (BOTs) are relatively young with good survival rates, conservative surgery is prioritized as a therapeutic intervention. However, the high recurrence rate of this tumor remains an issue that demands further attention. In addition, it is unclear whether the increment of recurrent risk is attributed to conservative surgery or staging surgery. This study was designed to analyze the relapse-related factors of BOTs. METHODS: This retrospective cohort study was comprised of 74 patients with BOTs who underwent surgery at the Obstetrics and Gynecology Hospital of Fudan University from September 2014 to September 2017. The recurrence-free survival (RFS) rate was calculated using the Kaplan-Meier method, while the risk factors of RFS were evaluated using Cox-regression analysis. RESULTS: The 3-year RFS was 2.7% with a median follow-up duration of 45 months (range: 28-62). Kaplan-Meier analysis indicated that low tumor node metastasis (TNM) stage (P = 0.005), lymphadenectomy (P = 0.052) and fertility-preservation surgery (P = 0.059) were the factors that may lower recurrence. Meanwhile, Cox-regression showed that only low TNM stage was significantly associated with a better RFS (P = 0.005). CONCLUSIONS: With the removal of visible lesions by standard surgery, patients at TNM stage I had a better RFS. Fertility-preservation surgery did not increase the recurrence risk. For bilateral ovarian cyst however, it was unclear whether bilateral cystectomy can increase the recurrence risk. Therefore, further study is required. AJTR
Authors: Koji Matsuo; Hiroko Machida; Tsuyoshi Takiuchi; Brendan H Grubbs; Lynda D Roman; Anil K Sood; David M Gershenson Journal: Gynecol Oncol Date: 2017-01-26 Impact factor: 5.482
Authors: Sherif A M Shazly; Shannon K Laughlin-Tommaso; Sean C Dowdy; Abimbola O Famuyide Journal: Am J Obstet Gynecol Date: 2016-04-27 Impact factor: 8.661
Authors: Se Ik Kim; Eun Ji Lee; Maria Lee; Hyunhoon Chung; Jae-Weon Kim; Noh Hyun Park; Yong-Sang Song; Hee Seung Kim Journal: Int J Gynecol Cancer Date: 2020-10-14 Impact factor: 3.437
Authors: María Guadalupe Patrono; Lucas Minig; Ivan Diaz-Padilla; Nuria Romero; Juan Francisco Rodriguez Moreno; Jesus Garcia-Donas Journal: Ecancermedicalscience Date: 2013-12-17