| Literature DB >> 36104518 |
Ju Hun Oh1, Ye Eon Han1, Ya Ru Bao1, Chan Woo Kang1, JaeHyung Koo2, Cheol Ryong Ku3, Yoon Hee Cho4, Eun Jig Lee5,6.
Abstract
The olfactory marker protein (OMP), which is also expressed in nonolfactory tissues, plays a role in regulating the kinetics and termination of olfactory transduction. Thus, we hypothesized that OMP may play a similar role in modulating the secretion of hormones involved in Ca2+ and cAMP signaling, such as glucagon. In the present study, we confirmed nonolfactory α-cell-specific OMP expression in human and mouse pancreatic islets as well as in the murine α-cell line αTC1.9. Glucagon and OMP expression increased under hyperglycemic conditions. Omp knockdown in hyperglycemic αTC1.9 cells using small-interfering RNA (siRNA) reduced the responses to glucagon release and the related signaling pathways compared with the si-negative control. The OMPlox/lox;GCGcre/w mice expressed basal glucagon levels similar to those in the wild-type OMPlox/lox mice but showed resistance against streptozotocin-induced hyperglycemia. The ectopic olfactory signaling events in pancreatic α-cells suggest that olfactory receptor pathways could be therapeutic targets for reducing excessive glucagon levels.Entities:
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Year: 2022 PMID： 36104518 PMCID： PMC9534918 DOI： 10.1038/s12276-022-00843-8
Source DB: PubMed Journal: Exp Mol Med ISSN： 1226-3613 Impact factor: 12.153