Literature DB >> 3610391

Receptors for epidermal growth factor and estradiol in canine mammary tumors.

V R Nerurkar, R Seshadri, R Mulherkar, C S Ishwad, V S Lalitha, S N Naik.   

Abstract

Both growth factors and steroid hormones are known to be associated with breast cancer. We have studied the epidermal growth factor receptor (EGFR) in canine mammary tumors and have shown the presence of a single class of 125I-EGF binding receptor sites in 9 out of 13 (70%) tumors, using Scatchard plot. The dissociation constant (KD) was 10(-9)M. An inverse correlation between EGFR and estrogen receptor (ER) was observed in 54% of the tumors. Our data suggest that EGFR might be used as a biochemical marker in canine mammary tumors.

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Year:  1987        PMID： 3610391     DOI： 10.1002/ijc.2910400218

Source DB:  PubMed          Journal:  Int J Cancer        ISSN： 0020-7136            Impact factor:   7.396


  3 in total

1.  Expression of HIF-1α ODD domain fused canine caspase 3 by EGFR promoter-driven adenovirus vector induces cytotoxicity in canine breast tumor cells under hypoxia.

Authors:  Mariko Okamoto; Ai Asamura; Ko Tanaka; Takefumi Soeda; Kyo Watanabe; Hiroyuki Mizuguchi; Teruo Ikeda
Journal:  Vet Res Commun       Date:  2016-10-16       Impact factor: 2.459

2.  Expression of epidermal growth factor receptor (EGFR) in non-affected and tumorous mammary tissue of female dogs.

Authors:  G R Rutteman; J A Foekens; H Portengen; J H Vos; M A Blankenstein; E Teske; C J Cornelisse; W Misdorp
Journal:  Breast Cancer Res Treat       Date:  1994       Impact factor: 4.872

3.  Expression of epidermal growth factor receptor (proto-oncogene c-erbB-1) and estrogen receptor in human breast carcinoma. An immunocytochemical study of 70 cases.

Authors:  C Garcìa Castro; M Ravina; V Castro; E C Salido
Journal:  Arch Gynecol Obstet       Date:  1993       Impact factor: 2.344
  3 in total

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