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Literature DB >> 3610324

Enzymatic inactivation of aztreonam by faecal enzyme preparations from healthy volunteers.

G W Welling, G Groen, S Welling-Wester, H G de Vries-Hospers, D van der Waaij.

Abstract

The enzymatic inactivation of aztreonam by the faecal flora was investigated in 25 healthy human volunteers. Ten volunteers received aztreonam orally and 15 volunteers did not receive antibiotic treatment. Residual aztreonam and its inactivated open ring form were simultaneously detected by an HPLC-assay. Independent of aztreonam treatment, beta-lactamase activity was detected in the faecal flora of 20 volunteers. The inactivation of aztreonam by the faecal supernatants was inhibited by clavulanic acid.

Entities: Chemical Species

Mesh：

Substances：
Aztreonam

Year: 1987 PMID： 3610324 DOI： 10.1007/bf01646046

Source DB: PubMed Journal: Infection ISSN： 0300-8126 Impact factor: 3.553

20 in total

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Authors: G Pinkus; G Veo; A I Braude
Journal: J Bacteriol Date: 1968-10 Impact factor: 3.490

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Authors: I Phillips; A King; K Shannon; C Warren
Journal: J Antimicrob Chemother Date: 1981-12 Impact factor: 5.790

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Authors: D M Livermore; J D Williams
Journal: J Antimicrob Chemother Date: 1981-12 Impact factor: 5.790

4. Infection prevention in granulocytopenic patients by selective decontamination of the digestive tract.

Authors: D T Sleijfer; N H Mulder; H G de Vries-Hospers; V Fidler; H O Nieweg; D van der Waaij; H K van Saene
Journal: Eur J Cancer Date: 1980-06 Impact factor: 9.162

5. Colonization resistance of the digestive tract: clinical consequences and implications.

Authors: D van der Waaij
Journal: J Antimicrob Chemother Date: 1982-10 Impact factor: 5.790

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Authors: D van der Waaij; J M Berghuis-de Vries
Journal: J Hyg (Lond) Date: 1971-09

7. Selective decontamination of the digestive tract with aztreonam: a study of 10 healthy volunteers.

Authors: H G de Vries-Hospers; G W Welling; E A Swabb; D van der Waaij
Journal: J Infect Dis Date: 1984-11 Impact factor: 5.226

8. A comparison of trimethoprim-sulfamethoxazole plus nystatin with gentamicin plus nystatin in the prevention of infections in acute leukemia.

Authors: J C Wade; S C Schimpff; M T Hargadon; C L Fortner; V M Young; P H Wiernik
Journal: N Engl J Med Date: 1981-04-30 Impact factor: 91.245

9. Metabolism of penicillins to penicilloic acids and 6-aminopenicillanic acid in man and its significance in assessing penicillin absorption.

Authors: M Cole; M D Kenig; V A Hewitt
Journal: Antimicrob Agents Chemother Date: 1973-04 Impact factor: 5.191

10. Augmentation of the in vitro activity of azlocillin against Bacteroides fragilis by clavulanic acid.

Authors: M B Bansal; S K Chuah; H Thadepalli
Journal: Antimicrob Agents Chemother Date: 1984-10 Impact factor: 5.191

5 in total

1. Comparison of the effects of aztreonam and tigemonam against Escherichia coli and Klebsiella pneumoniae in vitro and in vivo.

Authors: M L van Ogtrop; H Mattie; H F Guiot; E van Strijen; B R Sekh; R van Furth
Journal: Antimicrob Agents Chemother Date: 1991-03 Impact factor: 5.191

2. The effect of ceftriaxone on the anaerobic bacterial flora and the bacterial enzymatic activity in the intestinal tract.

Authors: G W Welling; G J Meijer-Severs; G Helmus; E van Santen; R H Tonk; H G de Vries-Hospers; D van der Waaij
Journal: Infection Date: 1991 Sep-Oct Impact factor: 3.553