Literature DB >> 36099905

A limb bud morphogen bites the dust.

Hyunji Lee1, Steven A Vokes2.   

Abstract

Hedgehog signaling has traditionally been considered to be a morphogen for digits. In this issue of Developmental Cell, Zhu et al. show that a brief exposure to Sonic Hedgehog is sufficient for digit specification, and this finding suggests that it is not acting as a direct morphogen but rather as an initiator of this process.
Copyright © 2022 Elsevier Inc. All rights reserved.

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Year:  2022        PMID: 36099905      PMCID: PMC9477441          DOI: 10.1016/j.devcel.2022.08.007

Source DB:  PubMed          Journal:  Dev Cell        ISSN: 1534-5807            Impact factor:   13.417


  10 in total

1.  Positional signalling and specification of digits in chick limb morphogenesis.

Authors:  C Tickle; D Summerbell; L Wolpert
Journal:  Nature       Date:  1975-03-20       Impact factor: 49.962

2.  Sonic hedgehog mediates the polarizing activity of the ZPA.

Authors:  R D Riddle; R L Johnson; E Laufer; C Tabin
Journal:  Cell       Date:  1993-12-31       Impact factor: 41.582

3.  Sonic hedgehog is not a limb morphogen but acts as a trigger to specify all digits in mice.

Authors:  Jianjian Zhu; Rashmi Patel; Anna Trofka; Brian D Harfe; Susan Mackem
Journal:  Dev Cell       Date:  2022-08-16       Impact factor: 13.417

4.  Attenuated sensing of SHH by Ptch1 underlies evolution of bovine limbs.

Authors:  Javier Lopez-Rios; Amandine Duchesne; Dario Speziale; Guillaume Andrey; Kevin A Peterson; Philipp Germann; Erkan Unal; Jing Liu; Sandrine Floriot; Sarah Barbey; Yves Gallard; Magdalena Müller-Gerbl; Andrew D Courtney; Christophe Klopp; Sabrina Rodriguez; Robert Ivanek; Christian Beisel; Carol Wicking; Dagmar Iber; Benoit Robert; Andrew P McMahon; Denis Duboule; Rolf Zeller
Journal:  Nature       Date:  2014-06-18       Impact factor: 49.962

5.  Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities.

Authors:  Brian D Harfe; Paul J Scherz; Sahar Nissim; Hua Tian; Andrew P McMahon; Clifford J Tabin
Journal:  Cell       Date:  2004-08-20       Impact factor: 41.582

6.  Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function.

Authors:  C Chiang; Y Litingtung; E Lee; K E Young; J L Corden; H Westphal; P A Beachy
Journal:  Nature       Date:  1996-10-03       Impact factor: 49.962

7.  Spatiotemporal regulation of GLI target genes in the mammalian limb bud.

Authors:  Jordan P Lewandowski; Fang Du; Shilu Zhang; Marian B Powell; Kristin N Falkenstein; Hongkai Ji; Steven A Vokes
Journal:  Dev Biol       Date:  2015-07-31       Impact factor: 3.582

8.  Progression of vertebrate limb development through SHH-mediated counteraction of GLI3.

Authors:  Pascal te Welscher; Aimée Zuniga; Sanne Kuijper; Thijs Drenth; Hans J Goedemans; Frits Meijlink; Rolf Zeller
Journal:  Science       Date:  2002-09-05       Impact factor: 47.728

9.  Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity.

Authors:  Ying Litingtung; Randall D Dahn; Yina Li; John F Fallon; Chin Chiang
Journal:  Nature       Date:  2002-08-18       Impact factor: 49.962

10.  GLI transcriptional repression is inert prior to Hedgehog pathway activation.

Authors:  Rachel K Lex; Weiqiang Zhou; Zhicheng Ji; Kristin N Falkenstein; Kaleigh E Schuler; Kathryn E Windsor; Joseph D Kim; Hongkai Ji; Steven A Vokes
Journal:  Nat Commun       Date:  2022-02-10       Impact factor: 17.694

  10 in total

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