Yajing Chen1, Qian Xu1, Li Wu1, Mengxi Zhou1, Yin Lin1, Yuhan Jiang1, Qing He1, Lei Zhao1, Yourong Dong1, Jianren Liu2, Wei Chen3. 1. Department of Neurology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 2. Department of Neurology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. liujr021@vip.163.com. 3. Department of Neurology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. david_chen8106@hotmail.com.
Abstract
BACKGROUND: Constipation, rapid eye movement sleep behavior disorder (RBD) and hyposmia are common prodromal symptoms of Parkinson's disease (PD), and they may represent two distinct types of disease origin, from the body or the brain. Our study aimed to compare the clinical characteristics of de novo PD patients with and without constipation and identify which prodromal symptoms were associated with constipation. METHODS: A total of 111 de novo, drug-naïve Chinese PD patients were consecutively enrolled from Jan 2017 to Sept 2021. Patients were classified into PD with and without constipation based on item 5 of the Scales for Outcomes in Parkinson's disease-Autonomic Dysfunction (SCOPA-AUT). The demographic data, motor, and non-motor symptoms were compared between the two groups. The associated factors of constipation were analyzed by the multivariate logistic regression analysis. RESULTS: In total, 44.1% (n = 49) of de novo PD patients had constipation. PD patients with constipation were older (p = 0.028), had higher proportions of Hoehn and Yahr (H-Y) stage [Formula: see text] 2 (p = 0.002), clinical possible RBD (cpRBD) (p = 0.002) and depression (p = 0.023), as well as marginal increase of hyposmia (p = 0.058) and freezing of gait (p = 0.069). After adjusting for H-Y stage and other confounding factors, cpRBD (OR = 3.508, p = 0.009), rather than hyposmia or depression, was closely related to constipation in de novo Chinese PD patients. CONCLUSIONS: RBD is closely associated with constipation in de novo Chinese PD patients. Our results support the theory that prodromal symptoms that represent the same pathological origin are closely related to each other.
BACKGROUND: Constipation, rapid eye movement sleep behavior disorder (RBD) and hyposmia are common prodromal symptoms of Parkinson's disease (PD), and they may represent two distinct types of disease origin, from the body or the brain. Our study aimed to compare the clinical characteristics of de novo PD patients with and without constipation and identify which prodromal symptoms were associated with constipation. METHODS: A total of 111 de novo, drug-naïve Chinese PD patients were consecutively enrolled from Jan 2017 to Sept 2021. Patients were classified into PD with and without constipation based on item 5 of the Scales for Outcomes in Parkinson's disease-Autonomic Dysfunction (SCOPA-AUT). The demographic data, motor, and non-motor symptoms were compared between the two groups. The associated factors of constipation were analyzed by the multivariate logistic regression analysis. RESULTS: In total, 44.1% (n = 49) of de novo PD patients had constipation. PD patients with constipation were older (p = 0.028), had higher proportions of Hoehn and Yahr (H-Y) stage [Formula: see text] 2 (p = 0.002), clinical possible RBD (cpRBD) (p = 0.002) and depression (p = 0.023), as well as marginal increase of hyposmia (p = 0.058) and freezing of gait (p = 0.069). After adjusting for H-Y stage and other confounding factors, cpRBD (OR = 3.508, p = 0.009), rather than hyposmia or depression, was closely related to constipation in de novo Chinese PD patients. CONCLUSIONS: RBD is closely associated with constipation in de novo Chinese PD patients. Our results support the theory that prodromal symptoms that represent the same pathological origin are closely related to each other.
Authors: Heiko Braak; Kelly Del Tredici; Udo Rüb; Rob A I de Vos; Ernst N H Jansen Steur; Eva Braak Journal: Neurobiol Aging Date: 2003 Mar-Apr Impact factor: 4.673
Authors: Jacob Horsager; Katrine B Andersen; Karoline Knudsen; Casper Skjærbæk; Tatyana D Fedorova; Niels Okkels; Eva Schaeffer; Sarah K Bonkat; Jacob Geday; Marit Otto; Michael Sommerauer; Erik H Danielsen; Einar Bech; Jonas Kraft; Ole L Munk; Sandra D Hansen; Nicola Pavese; Robert Göder; David J Brooks; Daniela Berg; Per Borghammer Journal: Brain Date: 2020-10-01 Impact factor: 13.501
Authors: G Pagano; T Yousaf; H Wilson; F Niccolini; S Polychronis; K R Chaudhuri; M Politis Journal: Eur J Neurol Date: 2017-12-11 Impact factor: 6.089
Authors: Valentina Leta; Daniele Urso; Lucia Batzu; Daniel Weintraub; Nataliya Titova; Dag Aarsland; Pablo Martinez-Martin; Per Borghammer; Daniel J van Wamelen; Tayyabah Yousaf; Alexandra Rizos; Carmen Rodriguez-Blazquez; Guy Chung-Faye; K Ray Chaudhuri Journal: J Parkinsons Dis Date: 2021 Impact factor: 5.568
Authors: Kerala L Adams-Carr; Jonathan P Bestwick; Samuel Shribman; Andrew Lees; Anette Schrag; Alastair J Noyce Journal: J Neurol Neurosurg Psychiatry Date: 2015-09-07 Impact factor: 10.154
Authors: Jarosław Dulski; Alexandra Estela Soto Piña; Rana Hanna Al-Shaikh; Leonard Petrucelli; Zbigniew K Wszolek Journal: Neurol Sci Date: 2022-09-23 Impact factor: 3.830