Literature DB >> 3609719

Testing the association between polymorphic markers and quantitative traits in pedigrees.

V T George, R C Elston.   

Abstract

A statistical model that uses an iterative maximum likelihood estimation procedure is proposed for measuring and testing the association between polymorphic genetic markers and quantitative traits in human pedigrees, after adjusting for covariates such as age and sex. The model allows the quantitative trait to have a familial correlation structure among the individuals in the sample and to follow one of a broad class of skewed or kurtotic underlying distributions. The use of the model is illustrated, and the results are compared to those using models that assume normality without any transformation and do not incorporate familial correlations.

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Year:  1987        PMID： 3609719     DOI： 10.1002/gepi.1370040304

Source DB:  PubMed          Journal:  Genet Epidemiol        ISSN： 0741-0395            Impact factor:   2.135


  36 in total

1.  A test of transmission/disequilibrium for quantitative traits in pedigree data, by multiple regression.

Authors:  V George; H K Tiwari; X Zhu; R C Elston
Journal:  Am J Hum Genet       Date:  1999-07       Impact factor: 11.025

2.  A general test of association for quantitative traits in nuclear families.

Authors:  G R Abecasis; L R Cardon; W O Cookson
Journal:  Am J Hum Genet       Date:  2000-01       Impact factor: 11.025

3.  Sibling-based tests of linkage and association for quantitative traits.

Authors:  D B Allison; M Heo; N Kaplan; E R Martin
Journal:  Am J Hum Genet       Date:  1999-06       Impact factor: 11.025

4.  Use of the robust sib-pair method to screen for single-locus, multiple-locus, and pleiotropic effects: application to traits related to hypertension.

Authors:  A F Wilson; R C Elston; L D Tran; R M Siervogel
Journal:  Am J Hum Genet       Date:  1991-05       Impact factor: 11.025

Review 5.  Overview of techniques to account for confounding due to population stratification and cryptic relatedness in genomic data association analyses.

Authors:  M J Sillanpää
Journal:  Heredity (Edinb)       Date:  2010-07-14       Impact factor: 3.821

6.  Genomewide rapid association using mixed model and regression: a fast and simple method for genomewide pedigree-based quantitative trait loci association analysis.

Authors:  Yurii S Aulchenko; Dirk-Jan de Koning; Chris Haley
Journal:  Genetics       Date:  2007-07-29       Impact factor: 4.562

7.  A unified association analysis approach for family and unrelated samples correcting for stratification.

Authors:  Xiaofeng Zhu; Shengchao Li; Richard S Cooper; Robert C Elston
Journal:  Am J Hum Genet       Date:  2008-02       Impact factor: 11.025

8.  Combined linkage disequilibrium and linkage mapping: Bayesian multilocus approach.

Authors:  P Pikkuhookana; M J Sillanpää
Journal:  Heredity (Edinb)       Date:  2013-11-20       Impact factor: 3.821

9.  Intrafamilial Aggregation and Heritability of Aortic Reflected (Backward) Waves Derived From Wave Separation Analysis.

Authors:  Arnaud T Djami-Tchatchou; Gavin R Norton; Andrew Raymond; Hendrik L Booysen; Bryan Hodson; Elena Libhaber; Pinhas Sareli; Angela J Woodiwiss
Journal:  Am J Hypertens       Date:  2015-04-22       Impact factor: 2.689

10.  A survey of haplotype variants at several disease candidate genes: the importance of rare variants for complex diseases.

Authors:  P-Y Liu; Y-Y Zhang; Y Lu; J-R Long; H Shen; Lan-J Zhao; F-H Xu; P Xiao; D-H Xiong; Y-J Liu; R R Recker; H-W Deng
Journal:  J Med Genet       Date:  2005-03       Impact factor: 6.318
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