Literature DB >> 3609660

Circadian variation in gastric emptying of meals in humans.

R H Goo, J G Moore, E Greenberg, N P Alazraki.   

Abstract

Circadian changes in drug absorption have been documented for several orally administered drugs in humans. To determine whether gastric emptying could account for these changes, morning (8 AM) and evening (8 PM) gastric emptying rates were measured in 16 healthy male subjects synchronized with diurnal activity and nocturnal rest. Gastric emptying half-times for the evening meal were significantly (p less than 0.001) longer for solids but not liquids when compared with morning emptying half-times. The increase in evening meal emptying time (53.6%) may account for the evening delay in reaching peak plasma concentrations documented for several drugs.

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Year:  1987        PMID： 3609660     DOI： 10.1016/0016-5085(87)90913-9

Source DB:  PubMed          Journal:  Gastroenterology        ISSN： 0016-5085            Impact factor:   22.682


  75 in total

1.  Regional differences in quinine absorption from the undisturbed human colon assessed using a timed release delivery system.

Authors:  J M Hebden; C G Wilson; R C Spiller; P J Gilchrist; E Blackshaw; M E Frier; A C Perkins
Journal:  Pharm Res       Date:  1999-07       Impact factor: 4.200

2.  First-in-human study of the pharmacokinetics and antiviral activity of IDX375, a novel nonnucleoside hepatitis C virus polymerase inhibitor.

Authors:  J de Bruijne; J van de Wetering de Rooij; A A van Vliet; X J Zhou; M F Temam; J Molles; J Chen; K Pietropaolo; J Z Sullivan-Bólyai; D Mayers; H W Reesink
Journal:  Antimicrob Agents Chemother       Date:  2012-06-04       Impact factor: 5.191

3.  [Circadian rhythms and clinical pharmacology].

Authors:  B Lemmer
Journal:  Internist (Berl)       Date:  2004-09       Impact factor: 0.743

4.  Is the timing of caloric intake associated with variation in diet-induced thermogenesis and in the metabolic pattern? A randomized cross-over study.

Authors:  S Bo; M Fadda; A Castiglione; G Ciccone; A De Francesco; D Fedele; A Guggino; M Parasiliti Caprino; S Ferrara; M Vezio Boggio; G Mengozzi; E Ghigo; M Maccario; F Broglio
Journal:  Int J Obes (Lond)       Date:  2015-07-29       Impact factor: 5.095

Review 5.  Gastroesophageal reflux disease and sleep disturbances.

Authors:  Yasuhiro Fujiwara; Tetsuo Arakawa; Ronnie Fass
Journal:  J Gastroenterol       Date:  2012-05-17       Impact factor: 7.527

6.  Multiple dose pharmacokinetics of a new once daily extended release tolterodine formulation versus immediate release tolterodine.

Authors:  B Olsson; J Szamosi
Journal:  Clin Pharmacokinet       Date:  2001       Impact factor: 6.447

7.  Clock is important for food and circadian regulation of macronutrient absorption in mice.

Authors:  Xiaoyue Pan; M Mahmood Hussain
Journal:  J Lipid Res       Date:  2009-04-22       Impact factor: 5.922

Review 8.  Exercise, energy balance and the shift worker.

Authors:  Greg Atkinson; Sarah Fullick; Charlotte Grindey; Don Maclaren
Journal:  Sports Med       Date:  2008       Impact factor: 11.136

9.  Comparison of aspiration and scintigraphic techniques for the measurement of gastric emptying rates of liquids in humans.

Authors:  E J Beckers; J B Leiper; J Davidson
Journal:  Gut       Date:  1992-01       Impact factor: 23.059

10.  Superior mesenteric artery blood flow and gastric emptying in humans and the differential effects of high fat and high carbohydrate meals.

Authors:  M B Sidery; I A Macdonald; P E Blackshaw
Journal:  Gut       Date:  1994-02       Impact factor: 23.059
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