Ryan D Ross1, Arnold Z Olali1, Qiuhu Shi2, Donald R Hoover3, Anjali Sharma4, Kathleen M Weber5, Audrey L French6, Heather McKay7, Phyllis C Tien8, Michael T Yin9, Leah H Rubin10. 1. Department of Cell and Molecular Medicine, Rush University Medical Center, Chicago, IL. 2. New York Medical College, Valhalla, NY. 3. Department of Statistics and Institute for Health, Health Care Policy and Aging Research, Rutgers University, Piscataway, NJ. 4. Albert Einstein College of Medicine, Bronx, NY. 5. Cook County Health/CORE Center and Hektoen Institute of Medicine, Chicago, IL. 6. Department of Medicine, Stroger Hospital of Cook County/CORE Center, Chicago, IL. 7. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD. 8. Department of Medicine, University of California, San Francisco and Medical Service, Department of Veteran Affairs Medical Center, San Francisco, CA. 9. Columbia University Medical Center, New York, NY; and. 10. Department of Neurology, Psychiatry, and Epidemiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Abstract
INTRODUCTION: Bone loss and cognitive impairment are common in women living with HIV (WLWH) and are exacerbated by menopause. Bone-derived undercarboxylated osteocalcin (ucOCN) and sclerostin appear to influence cognition. The current study investigated whether the circulating levels of these 2 proteins are associated with cognition in midlife WLWH and demographically similar HIV seronegative women. METHODS: Plasma samples from women enrolled in a musculoskeletal substudy within the Women's Interagency HIV Study were used to measure ucOCN and sclerostin. A neuropsychological (NP) test battery assessing executive function, processing speed, attention/working memory, learning, memory, verbal fluency, and motor function was administered within 6 months of musculoskeletal enrollment and every 2 years after (1-4 follow-up visits per participant). A series of generalized estimating equations were conducted to examine the association between biomarkers and NP performance at the initial assessment and over time in the total sample and in WLWH only. Primary predictors included biomarkers, time, and biomarker by time interactions. If the interaction terms were not significant, models were re-run without interactions. RESULTS: Neither biomarker predicted changes in NP performance over time in the total sample or in WLWH. ucOCN was positively associated with executive function in the total sample and in WLWH and with motor skills in WLWH. ucOCN was negatively associated with attention/working memory in the total sample. There were no significant associations between sclerostin and NP performance. CONCLUSION: The current study suggests an association between bone-derived ucOCN and cognition in women with and without HIV infection.
INTRODUCTION: Bone loss and cognitive impairment are common in women living with HIV (WLWH) and are exacerbated by menopause. Bone-derived undercarboxylated osteocalcin (ucOCN) and sclerostin appear to influence cognition. The current study investigated whether the circulating levels of these 2 proteins are associated with cognition in midlife WLWH and demographically similar HIV seronegative women. METHODS: Plasma samples from women enrolled in a musculoskeletal substudy within the Women's Interagency HIV Study were used to measure ucOCN and sclerostin. A neuropsychological (NP) test battery assessing executive function, processing speed, attention/working memory, learning, memory, verbal fluency, and motor function was administered within 6 months of musculoskeletal enrollment and every 2 years after (1-4 follow-up visits per participant). A series of generalized estimating equations were conducted to examine the association between biomarkers and NP performance at the initial assessment and over time in the total sample and in WLWH only. Primary predictors included biomarkers, time, and biomarker by time interactions. If the interaction terms were not significant, models were re-run without interactions. RESULTS: Neither biomarker predicted changes in NP performance over time in the total sample or in WLWH. ucOCN was positively associated with executive function in the total sample and in WLWH and with motor skills in WLWH. ucOCN was negatively associated with attention/working memory in the total sample. There were no significant associations between sclerostin and NP performance. CONCLUSION: The current study suggests an association between bone-derived ucOCN and cognition in women with and without HIV infection.
Authors: Ryan D Ross; Anjali Sharma; Qiuhu Shi; Donald R Hoover; Kathleen M Weber; Phyllis C Tien; Audrey L French; Lena Al-Harthi; Michael T Yin Journal: Bone Rep Date: 2020-05-11