Literature DB >> 36093372

Visceral Microscopic Pattern From Suicidal Ingestion of Professional Lysoform® With Delayed Death.

Stefano Tambuzzi, Guendalina Gentile, Salvatore Andreola, Arnaldo Stanislao Migliorini, Riccardo Zoja.   

Abstract

Lysoform® in the formulation of professional detergent is widely used in several fields, whereas its suicidal ingestion is an unusual occurrence. Therefore, the biological signs of this fatal poisoning remain unclear and elusive, similarly to the histological lesions induced by its main constituent, which is benzalkonium chloride (BZK). Furthermore, since all the deaths that has been reported in the literature occurred immediately, microscopic pictures of BZK lethal toxicity in subjects with prolonged survival have never been reported to date. Specifically, this brief communication reports the unique case of a woman who ingested professional Lysoform® to commit suicide, for which she died two weeks later. The autopsy examination showed either local or systemic signs of caustic ingestion; moreover, the histological analysis showed clear cellular damage of lungs, heart, and kidneys. In our case, toxicological investigations were not authorized as they were no longer considered significant. In this framework, the histological examination has therefore assumed a fundamental role in investigating and demonstrating the lethal effects caused by the systemic dissemination of BZK, which would otherwise no longer be investigable. Therefore, in cases of substance intoxication with prolonged survival where forensic toxicological investigations may be no longer possible or feasible, the histological examination may be the only resource to successfully observe and demonstrate its lethal effects.
© The Author(s) 2022.

Entities:  

Keywords:  BZK; Benzalkonium chloride; Forensic autopsy; Forensic pathology; Professional Lysoform®; Suicidal ingestion

Year:  2022        PMID: 36093372      PMCID: PMC9459401          DOI: 10.1177/19253621221119081

Source DB:  PubMed          Journal:  Acad Forensic Pathol        ISSN: 1925-3621


  16 in total

1.  Macroscopic and histopathological aspects of chemical damage to human tissues depending on the survival time.

Authors:  Alberto Amadasi; Guendalina Gentile; Alessandra Rancati; Riccardo Zoja
Journal:  Int J Legal Med       Date:  2015-09-18       Impact factor: 2.686

2.  Accidental benzalkonium chloride (zephiran) injection.

Authors:  Erdem Kilic; Nilay Er; Alper Alkan; Ayten Ferahbas
Journal:  Oral Surg Oral Med Oral Pathol Oral Radiol Endod       Date:  2011-10-19

3.  Survival after acute benzalkonium chloride poisoning.

Authors:  M van Berkel; F A de Wolff
Journal:  Hum Toxicol       Date:  1988-03

4.  Liquid chromatography-tandem mass spectrometry detection of benzalkonium chloride (BZK) in a forensic autopsy case with survival for 18 days post BZK ingestion.

Authors:  Satoko Mishima-Kimura; Kosei Yonemitsu; Yuki Ohtsu; Ako Sasao; Hiroshi Tsutsumi; Shota Furukawa; Yoko Nishitani
Journal:  Leg Med (Tokyo)       Date:  2018-03-02       Impact factor: 1.376

5.  Benzalkonium chloride poisoning in infant twins.

Authors:  J T Wilson; I M Burr
Journal:  Am J Dis Child       Date:  1975-10

6.  Benzalkonium chloride intoxication caused by intravenous self-injection.

Authors:  Masato Miyauchi; Makiko Hayashida; Hiroyuki Yokota
Journal:  Chudoku Kenkyu       Date:  2014-12

7.  Histological microaggregates as a sign of systemic dissemination due to oral ingestion of povidone-iodine (Betadine®).

Authors:  Stefano Tambuzzi; Guendalina Gentile; Nicola Galante; Alessandro Del Gobbo; Salvatore Andreola; Riccardo Zoja
Journal:  Leg Med (Tokyo)       Date:  2022-01-07       Impact factor: 1.376

8.  A case of fatal benzalkonium chloride poisoning.

Authors:  M Hitosugi; K Maruyama; A Takatsu
Journal:  Int J Legal Med       Date:  1998       Impact factor: 2.686

9.  Distribution and disposition of benzalkonium chloride following various routes of administration in rats.

Authors:  Yuying Xue; Yoko Hieda; Yoji Saito; Takeshi Nomura; Junko Fujihara; Koji Takayama; Kojiro Kimura; Haruo Takeshita
Journal:  Toxicol Lett       Date:  2004-03-14       Impact factor: 4.372

10.  Corrosive Esophagitis with Benzalkonium Chloride in a Two Days Old Neonate.

Authors:  Hasret Ayyildiz Civan; Didem Gulcu; Tulay Erkan
Journal:  Pediatr Gastroenterol Hepatol Nutr       Date:  2016-09-29
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