Niklas Gremke1, Sebastian Griewing2, Matthias Kalder2, Karel Kostev3. 1. Department of Gynecology and Obstetrics, University Hospital Marburg, Philipps-University Marburg, Baldingerstraße, 35043, Marburg, Germany. Gremken@staff.uni-marburg.de. 2. Department of Gynecology and Obstetrics, University Hospital Marburg, Philipps-University Marburg, Baldingerstraße, 35043, Marburg, Germany. 3. Epidemiology, IQVIA, Frankfurt, Germany.
Abstract
PURPOSE: The aim of this study was to analyze the prevalence of breast cancer in relation to body height and to investigate associations between body height and breast cancer in Germany. METHODS: This retrospective cohort study included 135,741 adult women followed in one of 161 gynecology practices in Germany between January 2019 and December 2021. The 3 year prevalence of breast cancer (ICD-10: C50) during the study period was shown in relation to body height, which was included in this study as a five-category variable for women: ≤ 160 cm, 161-165 cm, 166-170 cm, 171-175 cm, > 175 cm. The associations between height and breast cancer were analyzed using logistic regression models adjusted for age and BMI. RESULTS: The prevalence of breast cancer increased from 5.1% in women ≤ 160 cm to 6.8% in women > 175 cm in the age group 51-60, and from 9.2% in women ≤ 160 cm to 12.2% in women 171-175 cm in the age group > 60 years. The OR for breast cancer was 1.18 (95% CI 1.12-1.24) for every 10 cm increase in height. Compared to height ≤ 160 cm, the OR for height 166-170 cm was 1.26 (1.15-1.39), for 171-175 cm 1.43 (1.27-1.61), and for > 175 cm 1.49 (1.28-1.74). CONCLUSION: The results of this study suggest that greater body height in women is significantly related to an increased breast cancer risk.
PURPOSE: The aim of this study was to analyze the prevalence of breast cancer in relation to body height and to investigate associations between body height and breast cancer in Germany. METHODS: This retrospective cohort study included 135,741 adult women followed in one of 161 gynecology practices in Germany between January 2019 and December 2021. The 3 year prevalence of breast cancer (ICD-10: C50) during the study period was shown in relation to body height, which was included in this study as a five-category variable for women: ≤ 160 cm, 161-165 cm, 166-170 cm, 171-175 cm, > 175 cm. The associations between height and breast cancer were analyzed using logistic regression models adjusted for age and BMI. RESULTS: The prevalence of breast cancer increased from 5.1% in women ≤ 160 cm to 6.8% in women > 175 cm in the age group 51-60, and from 9.2% in women ≤ 160 cm to 12.2% in women 171-175 cm in the age group > 60 years. The OR for breast cancer was 1.18 (95% CI 1.12-1.24) for every 10 cm increase in height. Compared to height ≤ 160 cm, the OR for height 166-170 cm was 1.26 (1.15-1.39), for 171-175 cm 1.43 (1.27-1.61), and for > 175 cm 1.49 (1.28-1.74). CONCLUSION: The results of this study suggest that greater body height in women is significantly related to an increased breast cancer risk.
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