Literature DB >> 3607440

Microinjections of the gamma-aminobutyrate antagonist, bicuculline methiodide, into the caudate-putamen prevent amygdala-kindled seizures in rats.

E A Cavalheiro, Z A Bortolotto, L Turski.   

Abstract

We used amygdala-kindled seizures in rats to study the function of striatal gamma-aminobutyrate (GABA) in the regulation of the seizure threshold of the limbic forebrain. Microinjections of the GABAA antagonist, bicuculline methiodide, 1 pmol, into the caudate-putamen protected rats against amygdala-kindled seizures. This result shows that striatal GABA differentially modulates the threshold for limbic seizures.

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Year:  1987        PMID： 3607440     DOI： 10.1016/0006-8993(87)91089-4

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  7 in total

1.  Temporal sequence of ictal discharges propagation in the corticolimbic basal ganglia system during amygdala kindled seizures in freely moving rats.

Authors:  Li-Hong Shi; Fei Luo; Donald J Woodward; Dan C McIntyre; Jing-Yu Chang
Journal:  Epilepsy Res       Date:  2006-10-16       Impact factor: 3.045

Review 2.  Chemoconvulsant seizures: advantages of focally-evoked seizure models.

Authors:  K Gale
Journal:  Ital J Neurol Sci       Date:  1995 Feb-Mar

3.  Mediodorsal thalamus plays a critical role in the development of limbic motor seizures.

Authors:  R M Cassidy; K Gale
Journal:  J Neurosci       Date:  1998-11-01       Impact factor: 6.167

Review 4.  The role of the basal ganglia in the control of seizure.

Authors:  J Vuong; Annaelle Devergnas
Journal:  J Neural Transm (Vienna)       Date:  2017-08-01       Impact factor: 3.575

5.  It's a Storm, It's a Gale: Epilepsy Initiation From the Corticostriatal Circuit.

Authors:  Libor Velíšek
Journal:  Epilepsy Curr       Date:  2019-08-27       Impact factor: 7.500

Review 6.  Bypassing the Blood-Brain Barrier: Direct Intracranial Drug Delivery in Epilepsies.

Authors:  Manuela Gernert; Malte Feja
Journal:  Pharmaceutics       Date:  2020-11-24       Impact factor: 6.321

7.  Deep brain stimulation of the anterior nuclei of the thalamus relieves basal ganglia dysfunction in monkeys with temporal lobe epilepsy.

Authors:  Tingting Du; Yingchuan Chen; Lin Shi; Defeng Liu; Yuye Liu; Tianshuo Yuan; Xin Zhang; Guanyu Zhu; Jianguo Zhang
Journal:  CNS Neurosci Ther       Date:  2020-10-21       Impact factor: 5.243
  7 in total

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