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Literature DB >> 3607365

Activation of 5-HT3 receptor subtypes causes rapid excitation of rabbit parasympathetic neurones.

Abstract

Intracellular recordings were made from parasympathetic neurones of the rabbit vesical pelvic ganglia maintained in vitro. 5-Hydroxytryptamine (5-HT) caused a membrane depolarization which was antagonized by ICS 205-930 ([3 alpha-tropanyl]-1H-indole-3-carboxylic acid ester) but not by methysergide. ICS 205-930 caused a parallel shift to the right of the dose-response curve for 5-HT. These results suggest that the 5-HT3 receptor is involved in the membrane depolarization.

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Year: 1987 PMID： 3607365 PMCID： PMC1853566 DOI： 10.1111/j.1476-5381.1987.tb11236.x

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

15 in total

1. Serotonergic activation of tonic-type enteric neurons in guinea pig small bowel.

Authors: J D Wood; C J Mayer
Journal: J Neurophysiol Date: 1979-03 Impact factor: 2.714

2. Catecholamine, serotonin, and substance P-like peptide containing intrinsic neurons in the mudpuppy parasympathetic cardiac ganglion.

Authors: D S Neel; R L Parsons
Journal: J Neurosci Date: 1986-07 Impact factor: 6.167

3. Purinergic innervation of the guinea-pig urinary bladder.

Authors: G Burnstock; T Cocks; R Crowe; L Kasakov
Journal: Br J Pharmacol Date: 1978-05 Impact factor: 8.739

4. 5-HT hyperpolarization of bullfrog sympathetic ganglion cell membrane.

Authors: S Watanabe; K Koketsu
Journal: Experientia Date: 1973-11-15

5. The action of 5-hydroxytryptamine on single neurones of the rabbit superior cervical ganglion.

Authors: D I Wallis; R A North
Journal: Neuropharmacology Date: 1978-12 Impact factor: 5.250

6. Depolarizing responses recorded from nodose ganglion cells of the rabbit evoked by 5-hydroxytryptamine and other substances.

Authors: D I Wallis; C E Stansfeld; H L Nash
Journal: Neuropharmacology Date: 1982-01 Impact factor: 5.250

10. Some effects of 5-hydroxytryptamine, dopamine and noradrenaline on neurones in the submucous plexus of guinea-pig small intestine.

Authors: G D Hirst; E M Silinsky
Journal: J Physiol Date: 1975-10 Impact factor: 5.182

5 in total

Activation of 5-HT3 receptor subtypes causes rapid excitation of rabbit parasympathetic neurones.

1. Serotonergic activation of tonic-type enteric neurons in guinea pig small bowel.

2. Catecholamine, serotonin, and substance P-like peptide containing intrinsic neurons in the mudpuppy parasympathetic cardiac ganglion.

3. Purinergic innervation of the guinea-pig urinary bladder.

4. 5-HT hyperpolarization of bullfrog sympathetic ganglion cell membrane.

5. The action of 5-hydroxytryptamine on single neurones of the rabbit superior cervical ganglion.

6. Depolarizing responses recorded from nodose ganglion cells of the rabbit evoked by 5-hydroxytryptamine and other substances.

7. Cholinergic transmission in cat parasympathetic ganglia.

8. Multiple actions of 5-hydroxytryptamine on myenteric neurones of the guinea-pig ileum.

9. 5-Hydroxytryptamine receptors of visceral primary afferent neurones on rabbit nodose ganglia.

10. Some effects of 5-hydroxytryptamine, dopamine and noradrenaline on neurones in the submucous plexus of guinea-pig small intestine.

1. Blockade of 5-HT3 receptor-mediated currents in dissociated frog sensory neurones by benzoxazine derivative, Y-25130.

2. 5-Hydroxytryptamine acts at 5-HT2 receptors to decrease potassium conductance in rat nucleus accumbens neurones.

3. Transient and long-lasting actions of 5-HT on rat dentate gyrus neurones in vitro.

4. Activation of serotonin 3 receptors changes in vivo auditory responses in the mouse inferior colliculus.

5. Endothelin modulates calcium channel current in neurones of rabbit pelvic parasympathetic ganglia.