| Literature DB >> 36071531 |
Xueping Jiang1, Yangyi Li1, Nannan Zhang1, Yanping Gao1, Linzhi Han1, Shuying Li1, Jiali Li1, Xingyu Liu1, Yan Gong2,3, Conghua Xie4,5,6.
Abstract
Entities:
Year: 2022 PMID: 36071531 PMCID: PMC9450415 DOI: 10.1186/s13578-022-00882-8
Source DB: PubMed Journal: Cell Biosci ISSN: 2045-3701 Impact factor: 9.584
Fig. 8RRM2 silencing has anti-tumor effects and enhances CD8 + T cells infiltrations in Lewis mice model. Lewis mice were injected with LV-NC and LV-siRRM2 infected LLC cells. a The tumor volumes were measured every 3 days and depicted in the line chart. b, c Representative IVIS spectrum imaging for tumor-bearing mice. The fluorescence radiance comparison between LLC-LV-NC and LLC-LV-siRRM2 groups. d, e Representative fow cytometry of CD4 + and CD8 + T cells in spleens and tumors. Quantitative analysis of CD4 + and CD8 + T cells in spleens and tumors. f, g Representative image of CD4 and CD8 staining for spleens and tumors by IHC. Scale bar: 100 μm. *p < 0.05, **p < 0.01, ns: not significant