Literature DB >> 36071306

LncRNA SNHG25 Promotes Glioma Progression Through Activating MAPK Signaling.

Zeyu Wu1, Peng Lun1, Tao Ji2, Jiaojiao Niu3, Xiuyan Sun4, Xia Liu1, Jian Xu5.   

Abstract

Numerous studies indicated that long non-coding RNAs (lncRNAs) play critical roles in glioma initiation and progression. SNHG25 is a newly identified lncRNA. And the functional role and molecular mechanism of SNHG25 in glioma cells have not been investigated. In this study, we found that SNHG25 was upregulated in glioma cells and tissues. CCK-8, EDU, and colony formation assays demonstrated that SNHG25 knockdown markedly inhibited glioma cell proliferation. In vivo studies showed that SNHG25 knockdown significantly inhibited tumor growth. Further studies indicated that SNHG25 positively regulated MAP2K2 through sponging miR-579-5p. High expression of SNHG25 activated MAPK signaling through MAP2K2. These data suggest that SNHG25 is a potential target and biomarker for glioma.
© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  Glioma; MAP2k2; SNHG25; miR-579-5p

Mesh：

Substances：

Year:  2022        PMID： 36071306     DOI： 10.1007/s12035-022-03015-x

Source DB:  PubMed          Journal:  Mol Neurobiol        ISSN： 0893-7648            Impact factor:   5.682


  34 in total

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