Literature DB >> 3606960

Two different quadruplicated alpha globin gene arrangements.

Y C Gu, H Landman, T H Huisman.   

Abstract

The discovery of two different types of alpha globin gene quadruplication is reported. One with the alpha alpha alpha alpha (anti 3.7)/haplotype was present in four members of a Black family from Georgia, while a second with the alpha alpha alpha alpha (anti 4.2)/haplotype was observed in two members of an Indonesian family. Consistent clinical and haematological manifestations could be observed in these heterozygotes.

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Year:  1987        PMID： 3606960     DOI： 10.1111/j.1365-2141.1987.tb01306.x

Source DB:  PubMed          Journal:  Br J Haematol        ISSN： 0007-1048            Impact factor:   6.998


  4 in total

1.  Hb Costa Rica or alpha 2 beta 2 77(EF1)His --> Arg: the first example of a somatic cell mutation in a globin gene.

Authors:  W E Rodriguez Romero; M Castillo; M A Chaves; G F Saenz; L H Gu; J B Wilson; E Baysal; N S Smetanina; J Y Leonova; T H Huisman
Journal:  Hum Genet       Date:  1996-06       Impact factor: 4.132

Review 2.  The molecular pathology of the alpha globin genes.

Authors:  D J Weatherall; D R Higgs; J B Clegg
Journal:  Br J Cancer Suppl       Date:  1988-12

3.  The levels of zeta, gamma, and delta chains in patients with Hb H disease.

Authors:  F Kutlar; J M Gonzalez-Redondo; A Kutlar; A Gurgey; C Altay; G D Efremov; K Kleman; T H Huisman
Journal:  Hum Genet       Date:  1989-05       Impact factor: 4.132

4.  Alpha alpha alpha alpha anti-3.7 type II: a new alpha-globin gene rearrangement suggesting that the alpha-globin gene duplication could be caused by intrachromosomal recombination.

Authors:  M De Angioletti; G Lacerra; C Castaldo; R Cutolo; C de Bonis; G Buonanno; C Carestia
Journal:  Hum Genet       Date:  1992-04       Impact factor: 4.132
  4 in total

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