Emily J Mastej1, Michelle H Leppert2, Sharon Poisson2, Zak Ritchey3, Megan Barry4, Tatjana Rundek5, David S Liebeskind6, David Mirsky7, Timothy J Bernard4, Nicholas V Stence7. 1. Computational Bioscience Program, University of Colorado Anschutz, Aurora, CO, USA. 2. Department of Neurology, 12225University of Colorado School of Medicine, Aurora, CO, USA. 3. Department of Radiology, 12225University of Colorado School of Medicine, Aurora, CO, USA. 4. Section of Child Neurology, 2932Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, CO, USA. 5. Department of Neurology, 12235University of Miami Miller School of Medicine, Miami, FL, USA. 6. Department of Neurology, 8783University of California Los Angeles, Los Angeles, CA, USA. 7. Department of Radiology, Children's Hospital Colorado, Medicine, Aurora, CO, USA.
Abstract
Background: Younger stroke patients may suffer worse outcomes than older patients; however, the extent to which age at stroke impacts remote areas of the brain remains unclear. The objective of this study was to determine thalamic volume changes ipsilateral to middle cerebral artery territory strokes based on age at acute ischemic stroke onset. Methods: Acute ischemic stroke patients <9 years, 9-18 years, and >18 years old were retrospectively recruited from a large quaternary care system. Each subject underwent an acute (<72 hours from AIS) and chronic (>90 days) magnetic resonance imaging (MRI) scan. Manual thalamic segmentation was performed. Results: Younger and older children had significantly greater stroke-side thalamic volume loss compared to adults (48.2%, P = .022; 40.7%, P = .044, respectively). Conclusions: Stroke-side thalamic volumes decreased across the age spectrum but to a greater degree in pediatric patients. This observation can affect functional and cognitive outcomes post stroke and warrants further research.
Background: Younger stroke patients may suffer worse outcomes than older patients; however, the extent to which age at stroke impacts remote areas of the brain remains unclear. The objective of this study was to determine thalamic volume changes ipsilateral to middle cerebral artery territory strokes based on age at acute ischemic stroke onset. Methods: Acute ischemic stroke patients <9 years, 9-18 years, and >18 years old were retrospectively recruited from a large quaternary care system. Each subject underwent an acute (<72 hours from AIS) and chronic (>90 days) magnetic resonance imaging (MRI) scan. Manual thalamic segmentation was performed. Results: Younger and older children had significantly greater stroke-side thalamic volume loss compared to adults (48.2%, P = .022; 40.7%, P = .044, respectively). Conclusions: Stroke-side thalamic volumes decreased across the age spectrum but to a greater degree in pediatric patients. This observation can affect functional and cognitive outcomes post stroke and warrants further research.
Authors: Maureen Dennis; Brenda J Spiegler; Jenifer J Juranek; Erin D Bigler; O Carter Snead; Jack M Fletcher Journal: Neurosci Biobehav Rev Date: 2013-10-03 Impact factor: 8.989
Authors: Bin Jiang; Nancy K Hills; Rob Forsyth; Lori C Jordan; Mahmoud Slim; Steven G Pavlakis; Neil Freidman; Nomazulu Dlamini; Osman Farooq; Ying Li; Guangming Zhu; Heather Fullerton; Max Wintermark; Warren D Lo Journal: Stroke Date: 2020-12-07 Impact factor: 7.914