Literature DB >> 36068722

Simultaneous affinity maturation and developability enhancement using natural liability-free CDRs.

Andre A R Teixeira1, Sara D'Angelo2, M Frank Erasmus2, Camila Leal-Lopes1, Fortunato Ferrara2, Laura P Spector2, Leslie Naranjo2, Esteban Molina2, Tamara Max2, Ashley DeAguero2, Katherine Perea2, Shaun Stewart3, Rebecca A Buonpane3, Horacio G Nastri3, Andrew R M Bradbury2.   

Abstract

ABBREVIATIONS: CDR: complementarity determining region; FACS: fluorescence-activated cell sorting; ka: association rate; kd: dissociation rate; KD: dissociation constant; scFv: single-chain variable fragment; SPR: surface plasmon resonance.

Entities:  

Keywords:  Affinity maturation; CDR shuffling; developability; liability; library construction; off-rate; scFv

Mesh：

Substances：

Year:  2022        PMID： 36068722      PMCID： PMC9467613          DOI： 10.1080/19420862.2022.2115200

Source DB:  PubMed          Journal:  MAbs        ISSN： 1942-0862            Impact factor:   6.440


  69 in total

1.  Quantitative analysis of the effect of the mutation frequency on the affinity maturation of single chain Fv antibodies.

Authors:  P S Daugherty; G Chen; B L Iverson; G Georgiou
Journal:  Proc Natl Acad Sci U S A       Date:  2000-02-29       Impact factor: 11.205

2.  Fine affinity discrimination by yeast surface display and flow cytometry.

Authors:  J J VanAntwerp; K D Wittrup
Journal:  Biotechnol Prog       Date:  2000 Jan-Feb

3.  Affinity maturation of natural antibody using a chain shuffling technique and the expression of recombinant antibodies in Escherichia coli.

Authors:  S G Park; J S Lee; E Y Je; I J Kim; J H Chung; I H Choi
Journal:  Biochem Biophys Res Commun       Date:  2000-08-28       Impact factor: 3.575

4.  Tailoring in vitro selection for a picomolar affinity human antibody directed against vascular endothelial growth factor receptor 2 for enhanced neutralizing activity.

Authors:  Dan Lu; Juqun Shen; Marie D Vil; Haifan Zhang; Xenia Jimenez; Peter Bohlen; Larry Witte; Zhenping Zhu
Journal:  J Biol Chem       Date:  2003-08-12       Impact factor: 5.157

5.  Specificity improvement of a recombinant anti-testosterone Fab fragment by CDRIII mutagenesis and phage display selection.

Authors:  A Hemminki; S Niemi; A M Hoffrén; L Hakalahti; H Söderlund; K Takkinen
Journal:  Protein Eng       Date:  1998-04

6.  Using phage and yeast display to select hundreds of monoclonal antibodies: application to antigen 85, a tuberculosis biomarker.

Authors:  Fortunato Ferrara; Leslie A Naranjo; Sandeep Kumar; Tiziano Gaiotto; Harshini Mukundan; Basil Swanson; Andrew R M Bradbury
Journal:  PLoS One       Date:  2012-11-14       Impact factor: 3.240

7.  Scalable gene synthesis by selective amplification of DNA pools from high-fidelity microchips.

Authors:  Sriram Kosuri; Nikolai Eroshenko; Emily M Leproust; Michael Super; Jeffrey Way; Jin Billy Li; George M Church
Journal:  Nat Biotechnol       Date:  2010-11-28       Impact factor: 54.908

8.  Evidence supporting somatic assembly of the DNA segments (minigenes), coding for the framework, and complementarity-determining segments of immunoglobulin variable regions.

Authors:  E A Kabat; T T Wu; H Bilofsky
Journal:  J Exp Med       Date:  1979-06-01       Impact factor: 14.307

9.  Affinity improvement of a therapeutic antibody to methamphetamine and amphetamine through structure-based antibody engineering.

Authors:  Shraddha Thakkar; Nisha Nanaware-Kharade; Reha Celikel; Eric C Peterson; Kottayil I Varughese
Journal:  Sci Rep       Date:  2014-01-14       Impact factor: 4.379

10.  Extensive sequence and structural evolution of Arginase 2 inhibitory antibodies enabled by an unbiased approach to affinity maturation.

Authors:  Denice T Y Chan; Lesley Jenkinson; Stuart W Haynes; Mark Austin; Agata Diamandakis; Daniel Burschowsky; Chitra Seewooruthun; Alexandra Addyman; Sebastian Fiedler; Stephanie Ryman; Jessica Whitehouse; Louise H Slater; Ellen Gowans; Yoko Shibata; Michelle Barnard; Robert W Wilkinson; Tristan J Vaughan; Sarah V Holt; Vincenzo Cerundolo; Mark D Carr; Maria A T Groves
Journal:  Proc Natl Acad Sci U S A       Date:  2020-07-02       Impact factor: 11.205
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