| Literature DB >> 36068475 |
E Paylor Sachtleben1, Kelsey Rooney1, Hannah Haddad2, Victoria L Lassiegne3, Megan Boudreaux4, Elyse M Cornett5, Alan D Kaye6.
Abstract
Pharmacogenomics can improve pain management by considering individual variations in pain perception and susceptibility and sensitivity to medicines related to genetic diversity. Due to the subjective nature of pain and the fact that people respond differently to medicines, it can be challenging to develop a consistent and successful regimen for pain disorders. Numerous factors influence the outcome of pain treatment programs, but two stand out: altered perception of pain and varying responsiveness to analgesic medicines. Numerous polymorphisms in genes such as CYP2D6, OPRM1, and ABCB1 have been identified, culminating in a heterogeneous response to pain medication in people who have these genetic polymorphisms. Improved treatment regimens that factor in pharmacogenetic differences in patients would help reduce the risk of opioid dependency and help effectively treat postoperative pain.Entities:
Keywords: Acute pain; Chronic pain; Pain management; Pharmacogenetics; Pharmacogenomics; Postoperative pain; Precision medicine
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Year: 2022 PMID： 36068475 DOI： 10.1007/978-1-0716-2573-6_18
Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745