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Literature DB >> 36068473

Pharmacogenetics of Addiction Therapy.

David P Graham¹, Mark J Harding¹, David A Nielsen².

Abstract

Drug addiction is a serious relapsing disease that has high costs to society and to the individual addicts. Treatment of these addictions is still in its nascency, with only a few examples of successful therapies. Therapeutic response depends upon genetic, biological, social, and environmental components. A role for genetic makeup in the response to treatment has been shown for several addiction pharmacotherapies with response to treatment based on individual genetic makeup. In this chapter, we will discuss the role of genetics in pharmacotherapies, specifically for cocaine, alcohol, and opioid dependences. The continued elucidation of the role of genetics should aid in the development of new treatments and increase the efficacy of existing treatments.

Entities: Chemical

Keywords: Abuse; Addiction; Alcohol; Cocaine; Dependence; Drug; Gene; Opioid; Polymorphism; Therapy

Mesh：

Substances：
Cocaine

Year: 2022 PMID： 36068473 DOI： 10.1007/978-1-0716-2573-6_16

Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745

Keyword Cloud
References

341 in total

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Journal: Pain Med Date: 2008 May-Jun Impact factor: 3.750

Pharmacogenetics of Addiction Therapy.

Review 1. Genetic influences on impulsivity, risk taking, stress responsivity and vulnerability to drug abuse and addiction.

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