A Selective Review on the Novel Approaches and Potential Control Agents of Anti-biofouling and Anti-biofilming.

Specific aggregates of bacterial colonies, which, when embedded in a self-produced matrix, are known to cause biofouling. These complex structures are highly resistant to extreme stress conditions like antibiotics, complex cleaning strategies, or even the human immune system. The formation of biofilm matrices and biofouling is chosen as the preferred microbial environment owing to the advantages offered for the embedded cells for their long-term survival. This increased resistance and virulence emphasizes the urgency of finding newer alternatives for its complete eradication. Combined approaches using enzymes, biomimetic surface modification, and a fusion of physical and chemical methods are gaining more prominence. In brief, this review discusses the structure and biology of biofilms, their mechanism of action, and the new-age anti-biofilm and biofouling agents in food industries, bioelectric, and medical devices. Current anti-biofouling methods, including engineered polymers, surface coatings to antimicrobials, and antibiotics, have also been described.