Literature DB >> 3606608

Influence of association and of positive inotropic drugs on calcium binding to cardiac troponin C.

K Jaquet, L M Heilmeyer.   

Abstract

Isolated bovine cardiac troponin C forms dimers in presence of Mg2+ dependent on the protein concentration which has been determined by sedimentation velocity and sedimentation equilibrium. Dimer formation is correlated with a decrease in Ca2+ affinity. Positive inotropic drugs (benzimidazol derivatives) influence Ca2+ sensitivity either by changing the association state or by affecting the Ca2+ binding properties directly.

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Year:  1987        PMID： 3606608     DOI： 10.1016/0006-291x(87)91592-0

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  9 in total

1.  The 'calcium sensitising' effects of ORG30029 in saponin- or Triton-skinned rat cardiac muscle.

Authors:  D J Miller; D S Steele
Journal:  Br J Pharmacol       Date:  1990-08       Impact factor: 8.739

2.  Selective blockade of nicotinic acetylcholine receptors by pimobendan, a drug for the treatment of heart failure: reduction of catecholamine secretion and synthesis in adrenal medullary cells.

Authors:  Yumiko Toyohira; Tatsuhiko Kubo; Miyabi Watanabe; Yasuhito Uezono; Susumu Ueno; Koji Shinkai; Masato Tsutsui; Futoshi Izumi; Nobuyuki Yanagihara
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2005-02-16       Impact factor: 3.000

3.  Comparison of the effects of levosimendan, pimobendan, and milrinone on canine left ventricular-arterial coupling and mechanical efficiency.

Authors:  P S Pagel; D A Hettrick; D C Warltier
Journal:  Basic Res Cardiol       Date:  1996 Jul-Aug       Impact factor: 17.165

4.  Influence of the calcium-sensitizer UDCG-115 on hemodynamics and myocardial energetics in patients with idiopathic dilated cardiomyopathy. Comparison with nitroprusside.

Authors:  G Hasenfuss; C Holubarsch; H W Heiss; B Rattert; H Just
Journal:  Basic Res Cardiol       Date:  1989       Impact factor: 17.165

5.  Effect of pimobendan in patients with chronic heart failure.

Authors:  N Takeda; Y Hayashi; T Arino; A Takeda; K Noma
Journal:  Exp Clin Cardiol       Date:  2001

6.  The effects of reported Ca2+ sensitisers on the rates of Ca2+ release from cardiac troponin C and the troponin-tropomyosin complex.

Authors:  S J Smith; P J England
Journal:  Br J Pharmacol       Date:  1990-08       Impact factor: 8.739

7.  Challenging current paradigms related to cardiomyopathies. Are changes in the Ca2+ sensitivity of myofilaments containing cardiac troponin C mutations (G159D and L29Q) good predictors of the phenotypic outcomes?

Authors:  David Dweck; Nir Hus; James D Potter
Journal:  J Biol Chem       Date:  2008-09-26       Impact factor: 5.157

Review 8.  Pimobendan. A review of its pharmacology and therapeutic potential in congestive heart failure.

Authors:  A Fitton; R N Brogden
Journal:  Drugs Aging       Date:  1994-05       Impact factor: 3.923

9.  Calcium sensitizing action of carnosine and other endogenous imidazoles in chemically skinned striated muscle.

Authors:  C Lamont; D J Miller
Journal:  J Physiol       Date:  1992-08       Impact factor: 5.182
  9 in total

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