Literature DB >> 36065607

Reduced PU.1 Expression Collaborates with Tet2 Loss to Trigger Myeloid Leukemogenesis.

Wolfgang E Schleicher1, Eric M Pietras1,2.   

Abstract

The leukemic transformation of hematopoietic stem and progenitor cells in the setting of Tet2 deficiency is driven by PU.1 gene network loss through complementary reduction in PU.1 expression and hypermethylation of ETS loci at the enhancers of PU.1 target genes. See related article by Aivalioti et al., p. 444 (6). ©2022 American Association for Cancer Research.

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Year:  2022        PMID： 36065607      PMCID： PMC9445751          DOI： 10.1158/2643-3230.BCD-22-0100

Source DB:  PubMed          Journal:  Blood Cancer Discov        ISSN： 2643-3230


  10 in total

Review 1.  Genetic and epigenetic heterogeneity in acute myeloid leukemia.

Authors:  Sheng Li; Christopher E Mason; Ari Melnick
Journal:  Curr Opin Genet Dev       Date:  2016-05-07       Impact factor: 5.578

2.  Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation.

Authors:  Kelly Moran-Crusio; Linsey Reavie; Alan Shih; Omar Abdel-Wahab; Delphine Ndiaye-Lobry; Camille Lobry; Maria E Figueroa; Aparna Vasanthakumar; Jay Patel; Xinyang Zhao; Fabiana Perna; Suveg Pandey; Jozef Madzo; Chunxiao Song; Qing Dai; Chuan He; Sherif Ibrahim; Miloslav Beran; Jiri Zavadil; Stephen D Nimer; Ari Melnick; Lucy A Godley; Iannis Aifantis; Ross L Levine
Journal:  Cancer Cell       Date:  2011-06-30       Impact factor: 31.743

3.  Essential role of Jun family transcription factors in PU.1 knockdown-induced leukemic stem cells.

Authors:  Ulrich Steidl; Frank Rosenbauer; Roel G W Verhaak; Xuesong Gu; Alexander Ebralidze; Hasan H Otu; Steffen Klippel; Christian Steidl; Ingmar Bruns; Daniel B Costa; Katharina Wagner; Manuel Aivado; Guido Kobbe; Peter J M Valk; Emmanuelle Passegué; Towia A Libermann; Ruud Delwel; Daniel G Tenen
Journal:  Nat Genet       Date:  2006-10-15       Impact factor: 38.330

4.  PU.1-Dependent Enhancer Inhibition Separates Tet2-Deficient Hematopoiesis from Malignant Transformation.

Authors:  Maria M Aivalioti; Boris A Bartholdy; Kith Pradhan; Tushar D Bhagat; Aliona Zintiridou; Jong Jin Jeong; Victor J Thiruthuvanathan; Mario Pujato; Aditi Paranjpe; Chi Zhang; Ross L Levine; Aaron D Viny; Amittha Wickrema; Amit Verma; Britta Will
Journal:  Blood Cancer Discov       Date:  2022-09-06

Review 5.  Clonal hematopoiesis: Mutation-specific adaptation to environmental change.

Authors:  Marcus A Florez; Brandon T Tran; Trisha K Wathan; James DeGregori; Eric M Pietras; Katherine Y King
Journal:  Cell Stem Cell       Date:  2022-06-02       Impact factor: 25.269

6.  The Cell Type-Specific 5hmC Landscape and Dynamics of Healthy Human Hematopoiesis and TET2-Mutant Preleukemia.

Authors:  Yusuke Nakauchi; Armon Azizi; Daniel Thomas; M Ryan Corces; Andreas Reinisch; Rajiv Sharma; David Cruz Hernandez; Thomas Köhnke; Daiki Karigane; Amy Fan; Daniel Martinez-Krams; Melissa Stafford; Satinder Kaur; Ritika Dutta; Paul Phan; Asiri Ediriwickrema; Erin McCarthy; Yuhong Ning; Tierney Phillips; Christopher K Ellison; Gulfem D Guler; Anna Bergamaschi; Chin-Jen Ku; Samuel Levy; Ravindra Majeti
Journal:  Blood Cancer Discov       Date:  2022-07-06

7.  Minimal PU.1 reduction induces a preleukemic state and promotes development of acute myeloid leukemia.

Authors:  Britta Will; Thomas O Vogler; Swathi Narayanagari; Boris Bartholdy; Tihomira I Todorova; Mariana da Silva Ferreira; Jiahao Chen; Yiting Yu; Jillian Mayer; Laura Barreyro; Luis Carvajal; Daniela Ben Neriah; Michael Roth; Johanna van Oers; Sonja Schaetzlein; Christine McMahon; Winfried Edelmann; Amit Verma; Ulrich Steidl
Journal:  Nat Med       Date:  2015-09-07       Impact factor: 53.440

8.  PU.1 enforces quiescence and limits hematopoietic stem cell expansion during inflammatory stress.

Authors:  James S Chavez; Jennifer L Rabe; Dirk Loeffler; Kelly C Higa; Giovanny Hernandez; Taylor S Mills; Nouraiz Ahmed; Rachel L Gessner; Zhonghe Ke; Beau M Idler; Katia E Niño; Hyunmin Kim; Jason R Myers; Brett M Stevens; Pavel Davizon-Castillo; Craig T Jordan; Hideaki Nakajima; John Ashton; Robert S Welner; Timm Schroeder; James DeGregori; Eric M Pietras
Journal:  J Exp Med       Date:  2021-06-07       Impact factor: 14.307

9.  TET2 mutations are associated with hypermethylation at key regulatory enhancers in normal and malignant hematopoiesis.

Authors:  Morten Tulstrup; Mette Soerensen; Jakob Werner Hansen; Linn Gillberg; Maria Needhamsen; Katja Kaastrup; Kristian Helin; Kaare Christensen; Joachim Weischenfeldt; Kirsten Grønbæk
Journal:  Nat Commun       Date:  2021-10-18       Impact factor: 14.919

10.  Sustained PU.1 levels balance cell-cycle regulators to prevent exhaustion of adult hematopoietic stem cells.

Authors:  Philipp B Staber; Pu Zhang; Min Ye; Robert S Welner; César Nombela-Arrieta; Christian Bach; Marc Kerenyi; Boris A Bartholdy; Hong Zhang; Meritxell Alberich-Jordà; Sanghoon Lee; Henry Yang; Felicia Ng; Junyan Zhang; Mathias Leddin; Leslie E Silberstein; Gerald Hoefler; Stuart H Orkin; Berthold Göttgens; Frank Rosenbauer; Gang Huang; Daniel G Tenen
Journal:  Mol Cell       Date:  2013-02-08       Impact factor: 17.970
  10 in total

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