Literature DB >> 36058980

Genetic Determination of Regressive Pattern of Walker 256 Carcinosarcoma in Rats with Hypothalamic Diabetes Insipidus.

I I Khegay1.   

Abstract

We studied the growth dynamics of Walker 256 carcinosarcoma in recombinant progeny of dihybrid crosses of Brattleboro and WAG rats. A mutation in the vasopressin gene determining hypothalamic diabetes insipidus was detected in Brattleboro rats. WAG rats are carriers of normal vasopressin gene. Another interlinear difference was linked to tyrosinase gene controlling melanin synthesis. WAG rats express mutant allele determining albino phenotype. Brattleboro rats had normal working tyrosinase gene. F2 segregation yielded phenotypic classes with two patterns of tumor growth: linear growth or regression. Tumors regression was not linked to tyrosinase activity and was observed only in rats with diabetes insipidus. Analysis of mutants in next generations F3 and F4 confirmed this regularity in the Walker 256 carcinosarcoma growth pattern.
© 2022. Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  Walker 256 carcinosarcoma; albino; diabetes insipidus; tyrosinase; vasopressin

Mesh：

Substances：

Year:  2022        PMID： 36058980     DOI： 10.1007/s10517-022-05583-3

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.737


  8 in total

Review 1.  Vasopressin V1a and V1b receptors: from molecules to physiological systems.

Authors:  Taka-aki Koshimizu; Kazuaki Nakamura; Nobuaki Egashira; Masami Hiroyama; Hiroshi Nonoguchi; Akito Tanoue
Journal:  Physiol Rev       Date:  2012-10       Impact factor: 37.312

2.  Involvement of CX3CR1 in bone cancer pain through the activation of microglia p38 MAPK pathway in the spinal cord.

Authors:  Ji-Hua Hu; Jian-Ping Yang; Lei Liu; Cai-Fang Li; Li-Na Wang; Fu-Hai Ji; Hao Cheng
Journal:  Brain Res       Date:  2012-05-18       Impact factor: 3.252

3.  Proteomic analysis of long-term vasopressin action in the inner medullary collecting duct of the Brattleboro rat.

Authors:  Bas W M van Balkom; Jason D Hoffert; Chung-Lin Chou; Mark A Knepper
Journal:  Am J Physiol Renal Physiol       Date:  2003-10-07

4.  Sigma-1 Receptor Antagonist BD1047 Reduces Mechanical Allodynia in a Rat Model of Bone Cancer Pain through the Inhibition of Spinal NR1 Phosphorylation and Microglia Activation.

Authors:  Shanshan Zhu; Chenchen Wang; Yuan Han; Chao Song; Xueming Hu; Yannan Liu
Journal:  Mediators Inflamm       Date:  2015-11-30       Impact factor: 4.711

5.  Relating Doses of Contrast Agent Administered to TIC and Semi-Quantitative Parameters on DCE-MRI: Based on a Murine Breast Tumor Model.

Authors:  Menglin Wu; Li Lu; Qi Zhang; Qi Guo; Feixiang Zhao; Tongwei Li; Xuening Zhang
Journal:  PLoS One       Date:  2016-02-22       Impact factor: 3.240

Review 6.  The Walker 256 Breast Cancer Cell- Induced Bone Pain Model in Rats.

Authors:  Priyank A Shenoy; Andy Kuo; Irina Vetter; Maree T Smith
Journal:  Front Pharmacol       Date:  2016-08-31       Impact factor: 5.810

7.  Preclinical Efficacy of [V4 Q5 ]dDAVP, a Second Generation Vasopressin Analog, on Metastatic Spread and Tumor-Associated Angiogenesis in Colorectal Cancer.

Authors:  Juan Garona; Natasha T Sobol; Marina Pifano; Valeria I Segatori; Daniel E Gomez; Giselle V Ripoll; Daniel F Alonso
Journal:  Cancer Res Treat       Date:  2018-06-01       Impact factor: 4.679

8.  Origins of albino and hooded rats: implications from molecular genetic analysis across modern laboratory rat strains.

Authors:  Takashi Kuramoto; Satoshi Nakanishi; Masako Ochiai; Hitoshi Nakagama; Birger Voigt; Tadao Serikawa
Journal:  PLoS One       Date:  2012-08-16       Impact factor: 3.240
  8 in total

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