Literature DB >> 36058971

A Method to Determine Xenobiotic Acetylation Rate by Taq SNP rs1495741.

O B Ogarkov1, N P Peretolchina2, S I Malov3, E A Orlova1, L A Stepanenko3, P A Khromova1, I V Malov3, S I Kolesnikov1.   

Abstract

Drug acetylation plays an important role in the medical practice. Modern methods of acetylation phenotype prediction are based on genotyping of polymorphisms in the second exon of the gene NAT2. Some disadvantages of these methods limit their application in the clinical practice. We developed a method of human genotyping based on identification of NAT2 gene polymorphism rs1495741 by real-time PCR. This method of genotype determination has a number of advantages: high sensitivity, simplicity, possibility of automated interpretation of the results, and feasibility in clinical laboratories.
© 2022. Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  NAT2; PCR; SNP; acetylation; polymorphism

Mesh：

Substances：

Year:  2022        PMID： 36058971     DOI： 10.1007/s10517-022-05572-6

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.737


  8 in total

1.  The role of NAT2 polymorphism and methylation in anti-tuberculosis drug-induced liver injury in Mongolian tuberculosis patients.

Authors:  Dong Zhang; Jinqi Hao; Ruili Hou; Yanqin Yu; Baocui Hu; Liqin Wei
Journal:  J Clin Pharm Ther       Date:  2019-12-10       Impact factor: 2.512

2.  A single nucleotide polymorphism tags variation in the arylamine N-acetyltransferase 2 phenotype in populations of European background.

Authors:  Montserrat García-Closas; David W Hein; Debra Silverman; Núria Malats; Meredith Yeager; Kevin Jacobs; Mark A Doll; Jonine D Figueroa; Dalsu Baris; Molly Schwenn; Manolis Kogevinas; Alison Johnson; Nilanjan Chatterjee; Lee E Moore; Timothy Moeller; Francisco X Real; Stephen Chanock; Nathaniel Rothman
Journal:  Pharmacogenet Genomics       Date:  2011-04       Impact factor: 2.089

3.  Re-investigation of the concordance of human NAT2 phenotypes and genotypes.

Authors:  Hermann M Bolt; Silvia Selinski; Doris Dannappel; Meinolf Blaszkewicz; Klaus Golka
Journal:  Arch Toxicol       Date:  2004-11-19       Impact factor: 5.153

Review 4.  N-acetyltransferase SNPs: emerging concepts serve as a paradigm for understanding complexities of personalized medicine.

Authors:  David W Hein
Journal:  Expert Opin Drug Metab Toxicol       Date:  2009-04       Impact factor: 4.481

5.  The NAT2 tag SNP rs1495741 correlates with the susceptibility of antituberculosis drug-induced hepatotoxicity.

Authors:  Hsin-Tien Ho; Teng-Hsu Wang; Cheng-Huei Hsiong; Wann-Cherng Perng; Ning-Chi Wang; Tien-Yu Huang; Yuh-Jyh Jong; Po-Liang Lu; Oliver Yoa-Pu Hu
Journal:  Pharmacogenet Genomics       Date:  2013-04       Impact factor: 2.089

Review 6.  PharmGKB summary: very important pharmacogene information for N-acetyltransferase 2.

Authors:  Ellen M McDonagh; Sotiria Boukouvala; Eleni Aklillu; David W Hein; Russ B Altman; Teri E Klein
Journal:  Pharmacogenet Genomics       Date:  2014-08       Impact factor: 2.089

7.  Metabolic activation of N-hydroxyarylamines and N-hydroxyarylamides by 16 recombinant human NAT2 allozymes: effects of 7 specific NAT2 nucleic acid substitutions.

Authors:  D W Hein; M A Doll; T D Rustan; R J Ferguson
Journal:  Cancer Res       Date:  1995-08-15       Impact factor: 12.701

8.  A web server for inferring the human N-acetyltransferase-2 (NAT2) enzymatic phenotype from NAT2 genotype.

Authors:  Igor B Kuznetsov; Michael McDuffie; Roxana Moslehi
Journal:  Bioinformatics       Date:  2009-03-04       Impact factor: 6.937
  8 in total

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