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Literature DB >> 3605667

Epidural anesthesia with bupivacaine: effects of age on neural blockade and pharmacokinetics.

B T Veering, A G Burm, J W van Kleef, P J Hennis, J Spierdijk.

Abstract

Effects of aging after epidural administration of 0.5% bupivacaine without epinephrine were studied in two groups of patients, between 20 and 55 yr old and older than 55 yr, respectively. All patients received 95 mg bupivacaine HCl. The onset of analgesia in caudad segments decreased with age and the upper level of analgesia increased with age. Effects of age on duration of anesthesia could not be demonstrated. The total plasma clearance of bupivacaine decreased and the terminal half-life increased with age. Age had no effect on the peak plasma concentrations and time to peak concentrations.

Entities: Chemical Disease Species

Mesh：

Substances：
Bupivacaine

Year: 1987 PMID： 3605667

Source DB: PubMed Journal: Anesth Analg ISSN： 0003-2999 Impact factor: 5.108

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Cited

18 in total

Review 1. [Toxicology of local anesthetics. Clinical, therapeutic and pathological mechanisms].

Authors: W Zink; B M Graf
Journal: Anaesthesist Date: 2003-12 Impact factor: 1.041

2. The effect of age on the systemic absorption, disposition and pharmacodynamics of bupivacaine after epidural administration.

Authors: B T Veering; A G Burm; A A Vletter; R P van den Heuvel; W Onkenhout; J Spierdijk
Journal: Clin Pharmacokinet Date: 1992-01 Impact factor: 6.447

Epidural anesthesia with bupivacaine: effects of age on neural blockade and pharmacokinetics.

Review 1. [Toxicology of local anesthetics. Clinical, therapeutic and pathological mechanisms].

2. The effect of age on the systemic absorption, disposition and pharmacodynamics of bupivacaine after epidural administration.

3. Age does not influence the serum protein binding of bupivacaine.

Review 4. Anaesthesia in the elderly. Special considerations.

5. Epidural epinephrine and the systemic circulation during peripheral vascular surgery.

6. The authors respond.

7. Letter to the editor.

8. Age and bupivacaine plasma concentrations following radical cystectomy.

Review 9. Clinical pharmacokinetics of epidural and spinal anaesthesia.

10. [Anesthesiological care in orthogeriatric co-management. Perioperative treatment of geriatric trauma patients].