Ming-Guo Xie1,2, Jiao Qiao1,2, Xiongfei Wang1,2, Jian Zhou1,2, Yuguang Guan1,2, Changqing Liu1,2, Meng Zhao1,2, Tianfu Li2,3,4, Guoming Luan5,6,7. 1. Department of Neurosurgery, Epilepsy Center, Sanbo Brain Hospital, Capital Medical University, Xiangshan Yikesong Road 50, Haidian District, Beijing, 100093, China. 2. Beijing Key Laboratory of Epilepsy, Sanbo Brain Hospital, Capital Medical University, Beijing, China. 3. Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China. 4. Department of Neurology, Epilepsy Center, Sanbo Brain Hospital, Capital Medical University, Beijing, China. 5. Department of Neurosurgery, Epilepsy Center, Sanbo Brain Hospital, Capital Medical University, Xiangshan Yikesong Road 50, Haidian District, Beijing, 100093, China. luangm@ccmu.edu.cn. 6. Beijing Key Laboratory of Epilepsy, Sanbo Brain Hospital, Capital Medical University, Beijing, China. luangm@ccmu.edu.cn. 7. Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China. luangm@ccmu.edu.cn.
Abstract
PURPOSE: The aim of the study was to evaluate the cognitive functions and seizure outcomes of patients with low-grade epilepsy-associated neuroepithelial tumors (LEATs). METHODS: We retrospectively reviewed the clinical data of patients who underwent preoperative neuropsychological evaluations and subsequent epilepsy surgery for LEATs. The neuropsychological results of full-scaled intelligence quotient (FSIQ) and full-scaled memory quotient (FSMQ) were analyzed, as well as the postoperative seizure outcomes. RESULTS: Of the 138 patients included in the study, 59 patients (40.4%) were female and 47 (36.6%) patients were children. Preoperatively, 138 patients received FSIQ assessments and 30 patients (21.7%) had an intellectual deficit (FSIQ < 80 scores); 124 patients received FSMQ assessments and 32 patients (25.8%) had a memory deficit (FSMQ < 80 scores). Younger age at seizure onset (OR 0.93; P = 0.035) and discordant ictal electroencephalography (EEG) findings (OR 5.26; P = 0.001) were found to predict intellectual deficits, while abnormal hippocampus (OR 2.36; P = 0.051) as well as discordant ictal EEG findings (OR 4.03; P = 0.007) tended to cause memory deficits. During postoperative follow-up, 123 patients (90.7%) were followed up at least 12 months, and among them, 105 patients (85.4%) got seizure-free (Engel class I), while 18 patients (14.6%) were not (Engel class II-IV); longer duration of epilepsy (OR 1.01; P < 0.001) and discordant interictal EEG findings (OR 5.91; P = 0.005) were found to be related to poor seizure outcomes in patients with LEATs. CONCLUSION: Cognitive deficits commonly occur in patients with LEATs, especially in patients with early or childhood seizures. Early surgical intervention, however, could prevent most of patients from repeated seizure onsets and thus cognitive impairments.
PURPOSE: The aim of the study was to evaluate the cognitive functions and seizure outcomes of patients with low-grade epilepsy-associated neuroepithelial tumors (LEATs). METHODS: We retrospectively reviewed the clinical data of patients who underwent preoperative neuropsychological evaluations and subsequent epilepsy surgery for LEATs. The neuropsychological results of full-scaled intelligence quotient (FSIQ) and full-scaled memory quotient (FSMQ) were analyzed, as well as the postoperative seizure outcomes. RESULTS: Of the 138 patients included in the study, 59 patients (40.4%) were female and 47 (36.6%) patients were children. Preoperatively, 138 patients received FSIQ assessments and 30 patients (21.7%) had an intellectual deficit (FSIQ < 80 scores); 124 patients received FSMQ assessments and 32 patients (25.8%) had a memory deficit (FSMQ < 80 scores). Younger age at seizure onset (OR 0.93; P = 0.035) and discordant ictal electroencephalography (EEG) findings (OR 5.26; P = 0.001) were found to predict intellectual deficits, while abnormal hippocampus (OR 2.36; P = 0.051) as well as discordant ictal EEG findings (OR 4.03; P = 0.007) tended to cause memory deficits. During postoperative follow-up, 123 patients (90.7%) were followed up at least 12 months, and among them, 105 patients (85.4%) got seizure-free (Engel class I), while 18 patients (14.6%) were not (Engel class II-IV); longer duration of epilepsy (OR 1.01; P < 0.001) and discordant interictal EEG findings (OR 5.91; P = 0.005) were found to be related to poor seizure outcomes in patients with LEATs. CONCLUSION: Cognitive deficits commonly occur in patients with LEATs, especially in patients with early or childhood seizures. Early surgical intervention, however, could prevent most of patients from repeated seizure onsets and thus cognitive impairments.
Authors: Viola L Vogt; Juri-Alexander Witt; Daniel Delev; Alexander Grote; Marec von Lehe; Albert J Becker; Johannes Schramm; Christian E Elger; Christoph Helmstaedter Journal: Epilepsy Behav Date: 2018-09-10 Impact factor: 2.937
Authors: Andrew M Faramand; Nicola Barnes; Sue Harrison; Roxanna Gunny; Tom Jacques; M Zubair Tahir; Sophia M Varadkar; Helen J Cross; William Harkness; Martin M Tisdall Journal: Epilepsia Date: 2017-11-26 Impact factor: 5.864
Authors: Ingmar Blumcke; Roberto Spreafico; Gerrit Haaker; Roland Coras; Katja Kobow; Christian G Bien; Margarete Pfäfflin; Christian Elger; Guido Widman; Johannes Schramm; Albert Becker; Kees P Braun; Frans Leijten; Johannes C Baayen; Eleonora Aronica; Francine Chassoux; Hajo Hamer; Hermann Stefan; Karl Rössler; Maria Thom; Matthew C Walker; Sanjay M Sisodiya; John S Duncan; Andrew W McEvoy; Tom Pieper; Hans Holthausen; Manfred Kudernatsch; H Joachim Meencke; Philippe Kahane; Andreas Schulze-Bonhage; Josef Zentner; Dieter H Heiland; Horst Urbach; Bernhard J Steinhoff; Thomas Bast; Laura Tassi; Giorgio Lo Russo; Cigdem Özkara; Buge Oz; Pavel Krsek; Silke Vogelgesang; Uwe Runge; Holger Lerche; Yvonne Weber; Mrinalini Honavar; José Pimentel; Alexis Arzimanoglou; Adriana Ulate-Campos; Soheyl Noachtar; Elisabeth Hartl; Olaf Schijns; Renzo Guerrini; Carmen Barba; Thomas S Jacques; J Helen Cross; Martha Feucht; Angelika Mühlebner; Thomas Grunwald; Eugen Trinka; Peter A Winkler; Antonio Gil-Nagel; Rafael Toledano Delgado; Thomas Mayer; Martin Lutz; Basilios Zountsas; Kyriakos Garganis; Felix Rosenow; Anke Hermsen; Tim J von Oertzen; Thomas L Diepgen; Giuliano Avanzini Journal: N Engl J Med Date: 2017-10-26 Impact factor: 91.245