Literature DB >> 36052466

Persistent circulating SARS-CoV-2 spike is associated with post-acute COVID-19 sequelae.

Zoe Swank1,2,3, Yasmeen Senussi1,2,3, Zachary Manickas-Hill4, Xu G Yu1,4,5, Jonathan Z Li1,5, Galit Alter4,6, David R Walt1,2,3.   

Abstract

The diagnosis of post-acute sequelae of COVID-19 (PASC) poses an ongoing medical challenge. To identify biomarkers associated with PASC we analyzed plasma samples collected from PASC and COVID-19 patients to quantify viral antigens and inflammatory markers. We detect SARS-CoV-2 spike predominantly in PASC patients up to 12 months post-diagnosis.
© The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  COVID-19; SARS-CoV-2 antigens; long COVID; post-acute sequelae of COVID-19 (PASC); spike

Year:  2022        PMID： 36052466     DOI： 10.1093/cid/ciac722

Source DB:  PubMed          Journal:  Clin Infect Dis        ISSN： 1058-4838            Impact factor:   20.999


  5 in total

1.  SARS-CoV-2 spike S1 subunit protein-mediated increase of beta-secretase 1 (BACE1) impairs human brain vessel cells.

Authors:  Ji-Young Choi; Jung Hyun Park; Chulman Jo; Kyung-Chang Kim; Young Ho Koh
Journal:  Biochem Biophys Res Commun       Date:  2022-08-04       Impact factor: 3.322

Review 2.  The potential role of ischaemia-reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and therapeutic implications.

Authors:  Douglas B Kell; Etheresia Pretorius
Journal:  Biochem J       Date:  2022-08-31       Impact factor: 3.766

3.  SARS-CoV-2 and Toxoplasma gondii shared symptoms suggest muscle cells and neurons are their chronic infection reservoirs.

Authors:  Kevin Roe
Journal:  Hum Cell       Date:  2022-10-10       Impact factor: 4.374

4.  Impact of cross-coronavirus immunity in post-acute sequelae of COVID-19.

Authors:  Jonathan D Herman; Caroline Atyeo; Yonatan Zur; Claire E Cook; Naomi J Patel; Kathleen M Vanni; Emily N Kowalski; Grace Qian; Nancy A Shadick; Douglas Laffenburger; Zachary S Wallace; Jeffrey A Sparks; Galit Alter
Journal:  medRxiv       Date:  2022-09-26

Review 5.  Activation of TLR4 by viral glycoproteins: A double-edged sword?

Authors:  Emily A Halajian; Emmanuelle V LeBlanc; Katrina Gee; Che C Colpitts
Journal:  Front Microbiol       Date:  2022-09-29       Impact factor: 6.064
  5 in total

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