Literature DB >> 36051611

SARS-CoV-2 Effects on the Male Genitourinary System.

Zachary M Connelly1, Dustin Whitaker2, Alexandra Dullea3, Ranjith Ramasamy4.   

Abstract

SARS-CoV-2 infection arose in 2019 and has changed life as we know it. With our ever-advancing knowledge, therapies, and vaccines, more functions of the SARS-CoV-2 virus are being investigated outside of its pulmonary invasion. Here, we set out to review the current and pertinent literature on the impact of SARS-CoV-2 on the male genitourinary system including the bladder, lower urinary tract, prostate, testis, and penis. The biggest newsworthy stake was if SARS-CoV-2 could be transmitted through semen. Although initially thought to occur, more recent studies have opposed this hypothesis. Outside of the reproductive spread of SARS-CoV-2, multiple studies in this review highlight where the virus resides and what effect it may be having on this genitourinary system including increased voiding problems, viral persistence months after systemic clearance, and rare penile complications post-infection. Long-term outcomes are still needed to fully understand how SARS-CoV-2 infection can alter the genitourinary system. AJCEU
Copyright © 2022.

Entities:  

Keywords:  SARS-CoV-2; bladder; male reproduction; prostate; testes

Year:  2022        PMID: 36051611      PMCID: PMC9428573     

Source DB:  PubMed          Journal:  Am J Clin Exp Urol        ISSN: 2330-1910


  49 in total

1.  Mondor's Disease in SARS-CoV-2 Infection: A Case of Superficial Vein Thrombosis in the Era of COVID-19.

Authors:  Gianfranco Lessiani; Andrea Boccatonda; Damiano D'Ardes; Giulio Cocco; Giuseppe Di Marco; Cosima Schiavone
Journal:  Eur J Case Rep Intern Med       Date:  2020-09-01

Review 2.  Sex differences in COVID-19: the role of androgens in disease severity and progression.

Authors:  Mohamed S Mohamed; Thiago C Moulin; Helgi B Schiöth
Journal:  Endocrine       Date:  2020-11-11       Impact factor: 3.633

3.  Evaluation of SARS-CoV-2 in Human Semen and Effect on Total Sperm Number: A Prospective Observational Study.

Authors:  Jordan C Best; Manish Kuchakulla; Kajal Khodamoradi; Thiago Fernandes Negris Lima; Fabio Stefano Frech; Justin Achua; Omar Rosete; Belén Mora; Himanshu Arora; Emad Ibrahim; Ranjith Ramasamy
Journal:  World J Mens Health       Date:  2021-02-24       Impact factor: 5.400

4.  COVID-19 Endothelial Dysfunction Can Cause Erectile Dysfunction: Histopathological, Immunohistochemical, and Ultrastructural Study of the Human Penis.

Authors:  Eliyahu Kresch; Justin Achua; Russell Saltzman; Kajal Khodamoradi; Himanshu Arora; Emad Ibrahim; Oleksandr N Kryvenko; Vania Wolff Almeida; Fakiha Firdaus; Joshua M Hare; Ranjith Ramasamy
Journal:  World J Mens Health       Date:  2021-05-07       Impact factor: 5.400

5.  The Breadth of Viruses in Human Semen.

Authors:  Alex P Salam; Peter W Horby
Journal:  Emerg Infect Dis       Date:  2017-11       Impact factor: 6.883

6.  Effect of COVID-19 on Male Reproductive System - A Systematic Review.

Authors:  Yanfei He; Jie Wang; Junlin Ren; Yubo Zhao; Jing Chen; Xuejiao Chen
Journal:  Front Endocrinol (Lausanne)       Date:  2021-05-27       Impact factor: 5.555

7.  Cell entry mechanisms of SARS-CoV-2.

Authors:  Jian Shang; Yushun Wan; Chuming Luo; Gang Ye; Qibin Geng; Ashley Auerbach; Fang Li
Journal:  Proc Natl Acad Sci U S A       Date:  2020-05-06       Impact factor: 11.205

8.  A systematic review on COVID-19: urological manifestations, viral RNA detection and special considerations in urological conditions.

Authors:  Vinson Wai-Shun Chan; Peter Ka-Fung Chiu; Chi-Hang Yee; Yuhong Yuan; Chi-Fai Ng; Jeremy Yuen-Chun Teoh
Journal:  World J Urol       Date:  2020-05-27       Impact factor: 4.226

9.  Expression of ACE2, the SARS-CoV-2 Receptor, and TMPRSS2 in Prostate Epithelial Cells.

Authors:  Hanbing Song; Bobak Seddighzadeh; Matthew R Cooperberg; Franklin W Huang
Journal:  Eur Urol       Date:  2020-05-06       Impact factor: 20.096

10.  Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection.

Authors:  Xin Zou; Ke Chen; Jiawei Zou; Peiyi Han; Jie Hao; Zeguang Han
Journal:  Front Med       Date:  2020-03-12       Impact factor: 4.592

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