Michal J Lewandowski1, Simon Krenn1, Amelie Kurnikowski1, Philipp Bretschneider1, Martina Sattler1, Elisabeth Schwaiger1,2, Marlies Antlanger2, Philipp Gauckler3, Markus Pirklbauer3, Maria Brunner4, Sabine Horn4, Emanuel Zitt5, Bernhard Kirsch6, Martin Windpessl7, Manfred Wallner7, Ida Aringer8, Martin Wiesholzer8, Manfred Hecking1, Sebastian Hödlmoser9,10. 1. Department of Internal Medicine III, Clinical Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria. 2. Department of Internal Medicine II, Keplerklinikum Linz, Linz, Austria. 3. Department of Internal Medicine IV (Nephrology and Hypertension), Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria. 4. Department of Internal Medicine, Landeskrankhaus Villach, Villach, Austria. 5. Department of Internal Medicine III, Landeskrankenhaus Feldkirch, Feldkirch, Austria. 6. Department of Internal Medicine III, Landesklinikum Mistelbach, Mistelbach, Austria. 7. Department of Internal Medicine IV, Klinikum Wels-Grieskirchen, Wels, Austria. 8. Department of Internal Medicine I, Universitätsklinikum St. Pölten, St. Pölten, Austria. 9. Department of Internal Medicine III, Clinical Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria. sebastian.hoedlmoser@meduniwien.ac.at. 10. Department of Epidemiology, Center for Public Health, Medical University of Vienna, Vienna, Austria. sebastian.hoedlmoser@meduniwien.ac.at.
Abstract
BACKGROUND: A discrepancy between sex-specific treatment of kidney failure by dialysis (higher in men) and the prevalence of chronic kidney disease in the general population (higher in women) has been reported internationally, but the prevalence by sex has not been described for Austria. Sex disparity among nephrology outpatients has not been studied. METHODS: We employed two formulae (2009 CKD-EPI suppressing the race factor, and race-free 2021 CKD-EPI) to estimate the sex distribution of CKD in Austrian primary care, based on creatinine measurements recorded in a medical sample of 39,800 patients from general practitioners' offices (1989-2008). Further, we collected information from all clinic appointments scheduled at nephrology departments of 6 Austrian hospitals (Wien, Linz, Wels, St. Pölten, Villach, Innsbruck) during 2019 and calculated visit frequencies by sex. RESULTS: Using the 2009 CKD-EPI formula, the prevalence of CKD in stages G3-G5 (estimated glomerular filtration rate < 60 mL/min/1.73 m2) was 16.4% among women and 8.5% among men aged > 18 years who had attended general practitioners' offices in Austria between 1989 and 2008 and had at least one creatinine measurement performed. Using the 2021 CKD-EPI formula, the respective CKD prevalence was 12.3% among women and 6.1% among men. In 2019, 45% of all outpatients at 6 participating nephrology departments were women. The median of nephrology clinic visits in 2019 was two (per year) for both sexes. CONCLUSION: CKD is more prevalent among Austrian women than men. Men are more prevalent in nephrology outpatient services. Research into causes of this sex disparity is urgently needed.
BACKGROUND: A discrepancy between sex-specific treatment of kidney failure by dialysis (higher in men) and the prevalence of chronic kidney disease in the general population (higher in women) has been reported internationally, but the prevalence by sex has not been described for Austria. Sex disparity among nephrology outpatients has not been studied. METHODS: We employed two formulae (2009 CKD-EPI suppressing the race factor, and race-free 2021 CKD-EPI) to estimate the sex distribution of CKD in Austrian primary care, based on creatinine measurements recorded in a medical sample of 39,800 patients from general practitioners' offices (1989-2008). Further, we collected information from all clinic appointments scheduled at nephrology departments of 6 Austrian hospitals (Wien, Linz, Wels, St. Pölten, Villach, Innsbruck) during 2019 and calculated visit frequencies by sex. RESULTS: Using the 2009 CKD-EPI formula, the prevalence of CKD in stages G3-G5 (estimated glomerular filtration rate < 60 mL/min/1.73 m2) was 16.4% among women and 8.5% among men aged > 18 years who had attended general practitioners' offices in Austria between 1989 and 2008 and had at least one creatinine measurement performed. Using the 2021 CKD-EPI formula, the respective CKD prevalence was 12.3% among women and 6.1% among men. In 2019, 45% of all outpatients at 6 participating nephrology departments were women. The median of nephrology clinic visits in 2019 was two (per year) for both sexes. CONCLUSION: CKD is more prevalent among Austrian women than men. Men are more prevalent in nephrology outpatient services. Research into causes of this sex disparity is urgently needed.
Authors: Alessandro Gasparini; Marie Evans; Josef Coresh; Morgan E Grams; Olof Norin; Abdul R Qureshi; Björn Runesson; Peter Barany; Johan Ärnlöv; Tomas Jernberg; Björn Wettermark; Carl G Elinder; Juan-Jesüs Carrero Journal: Nephrol Dial Transplant Date: 2016-10-13 Impact factor: 5.992
Authors: Daniel Murphy; Charles E McCulloch; Feng Lin; Tanushree Banerjee; Jennifer L Bragg-Gresham; Mark S Eberhardt; Hal Morgenstern; Meda E Pavkov; Rajiv Saran; Neil R Powe; Chi-Yuan Hsu Journal: Ann Intern Med Date: 2016-08-02 Impact factor: 25.391