| Literature DB >> 36042205 |
Weicai Huang1,2, Yuming Jiang1,2, Wenjun Xiong3, Zepang Sun1,2, Chuanli Chen4, Qingyu Yuan4, Kangneng Zhou5, Zhen Han1,2, Hao Feng1,2, Hao Chen1,2, Xiaokun Liang6, Shitong Yu1,2, Yanfeng Hu1,2, Jiang Yu1,2, Yan Chen7, Liying Zhao1,2, Hao Liu1,2, Zhiwei Zhou8,9, Wei Wang11,12, Wei Wang11,12, Yikai Xu13, Guoxin Li14,15.
Abstract
The tumor immune microenvironment (TIME) is associated with tumor prognosis and immunotherapy response. Here we develop and validate a CT-based radiomics score (RS) using 2272 gastric cancer (GC) patients to investigate the relationship between the radiomics imaging biomarker and the neutrophil-to-lymphocyte ratio (NLR) in the TIME, including its correlation with prognosis and immunotherapy response in advanced GC. The RS achieves an AUC of 0.795-0.861 in predicting the NLR in the TIME. Notably, the radiomics imaging biomarker is indistinguishable from the IHC-derived NLR status in predicting DFS and OS in each cohort (HR range: 1.694-3.394, P < 0.001). We find the objective responses of a cohort of anti-PD-1 immunotherapy patients is significantly higher in the low-RS group (60.9% and 42.9%) than in the high-RS group (8.1% and 14.3%). The radiomics imaging biomarker is a noninvasive method to evaluate TIME, and may correlate with prognosis and anti PD-1 immunotherapy response in GC patients.Entities:
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Year: 2022 PMID： 36042205 PMCID： PMC9427761 DOI： 10.1038/s41467-022-32816-w
Source DB: PubMed Journal: Nat Commun ISSN： 2041-1723 Impact factor: 17.694