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Literature DB >> 36041950

Sterols in asthma.

Mireia Guerau-de-Arellano¹, Rodney D Britt².

Abstract

While sterols regulate immune processes key to the pathogenesis of asthma, inhibition of sterols with statin drugs has shown conflicting results in human asthma. Here, a novel understanding of the impact of sterols on type 17 immune responses and asthma lead us to hypothesize that sterols and statins may be relevant to severe asthma endotypes with neutrophil infiltration.

Entities: Chemical

Keywords: Th17; asthma; neutrophilic; severe; statin; sterol

Mesh：

Substances：

Year: 2022 PMID： 36041950 PMCID： PMC9513744 DOI： 10.1016/j.it.2022.08.003

Source DB: PubMed Journal: Trends Immunol ISSN： 1471-4906 Impact factor: 19.709

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References

59 in total

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Sterols in asthma.

Review 1. Promise of low-density lipoprotein-lowering therapy for primary and secondary prevention.

2. T(H)17-associated cytokines (IL-17A and IL-17F) in severe asthma.

3. Statin exposure is associated with decreased asthma-related emergency department visits and oral corticosteroid use.

4. Oral Glucocorticoid-Sparing Effect of Benralizumab in Severe Asthma.

5. Sterol metabolism controls T(H)17 differentiation by generating endogenous RORγ agonists.

6. Protein arginine methyltransferase 5 promotes cholesterol biosynthesis-mediated Th17 responses and autoimmunity.

Review 7. Understanding Asthma Phenotypes, Endotypes, and Mechanisms of Disease.

8. LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling.

Review 9. Statins in Asthma: Potential Beneficial Effects and Limitations.

10. A Transcriptomic Method to Determine Airway Immune Dysfunction in T2-High and T2-Low Asthma.