Literature DB >> 36039791

γ-Secretase as a drug target for familial Alzheimer's disease: the road less traveled.

Michael S Wolfe1.   

Abstract

Entities:  

Keywords:  amyloid; mutations; proteolysis

Mesh：

Substances：

Year:  2022        PMID： 36039791      PMCID： PMC9518009          DOI： 10.4155/fmc-2022-0178

Source DB:  PubMed          Journal:  Future Med Chem        ISSN： 1756-8919            Impact factor:   4.767


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  14 in total

1.  A phase 3 trial of semagacestat for treatment of Alzheimer's disease.

Authors:  Rachelle S Doody; Rema Raman; Martin Farlow; Takeshi Iwatsubo; Bruno Vellas; Steven Joffe; Karl Kieburtz; Feng He; Xiaoying Sun; Ronald G Thomas; Paul S Aisen; Eric Siemers; Gopalan Sethuraman; Richard Mohs
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Review 2.  Alzheimer's disease.

Authors:  Henry W Querfurth; Frank M LaFerla
Journal:  N Engl J Med       Date:  2010-01-28       Impact factor: 91.245

3.  Recognition of the amyloid precursor protein by human γ-secretase.

Authors:  Rui Zhou; Guanghui Yang; Xuefei Guo; Qiang Zhou; Jianlin Lei; Yigong Shi
Journal:  Science       Date:  2019-01-10       Impact factor: 47.728

Review 4.  The amyloid cascade and Alzheimer's disease therapeutics: theory versus observation.

Authors:  Rudy J Castellani; Germán Plascencia-Villa; George Perry
Journal:  Lab Invest       Date:  2019-02-13       Impact factor: 5.662

Review 5.  The genetics of Alzheimer disease.

Authors:  Rudolph E Tanzi
Journal:  Cold Spring Harb Perspect Med       Date:  2012-10-01       Impact factor: 6.915

Review 6.  One Size Does Not Fit All: The Past, Present and Future of Cystic Fibrosis Causal Therapies.

Authors:  Marjolein M Ensinck; Marianne S Carlon
Journal:  Cells       Date:  2022-06-08       Impact factor: 7.666

Review 7.  A new era in the treatment of cystic fibrosis: correction of the underlying CFTR defect.

Authors:  Michael P Boyle; Kris De Boeck
Journal:  Lancet Respir Med       Date:  2013-01-30       Impact factor: 30.700

Review 8.  Cystic fibrosis.

Authors:  Brian P O'Sullivan; Steven D Freedman
Journal:  Lancet       Date:  2009-05-04       Impact factor: 79.321

9.  gamma-Secretase: successive tripeptide and tetrapeptide release from the transmembrane domain of beta-carboxyl terminal fragment.

Authors:  Mako Takami; Yu Nagashima; Yoshihisa Sano; Seiko Ishihara; Maho Morishima-Kawashima; Satoru Funamoto; Yasuo Ihara
Journal:  J Neurosci       Date:  2009-10-14       Impact factor: 6.167

10.  Targeting Prodromal Alzheimer Disease With Avagacestat: A Randomized Clinical Trial.

Authors:  Vladimir Coric; Stephen Salloway; Christopher H van Dyck; Bruno Dubois; Niels Andreasen; Mark Brody; Craig Curtis; Hilkka Soininen; Stephen Thein; Thomas Shiovitz; Gary Pilcher; Steven Ferris; Susan Colby; Wendy Kerselaers; Randy Dockens; Holly Soares; Stephen Kaplita; Feng Luo; Chahin Pachai; Luc Bracoud; Mark Mintun; Joshua D Grill; Ken Marek; John Seibyl; Jesse M Cedarbaum; Charles Albright; Howard H Feldman; Robert M Berman
Journal:  JAMA Neurol       Date:  2015-11       Impact factor: 18.302
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