A Mixed-Methods Study of COVID-19 Vaccine Acceptance and Its Determinants Among Pregnant Women in Northeast Ethiopia.

Background: The World Health Organization recommends that pregnant women should receive a vaccine against COVID-19. However, COVID-19 vaccine hesitance was one of the barriers to delivering the vaccine, and this issue was not well addressed in Ethiopia. Therefore, we aimed to determine the prevalence of COVID-19 vaccination acceptability and the factors that influence it among pregnant women in Northeast Ethiopia.
Methods: A mixed-methods approach comprising both qualitative interviews and a quantitative survey was conducted from January 1-30, 2022. For the quantitative part, a multi-stage sampling technique was used to recruit the study participants (n=702). Data was collected through face-to-face interviews using pretested and structured questionnaires. Bivariate and multivariable logistic regression analyses were employed. The statistical difference was considered at P-0.05, and the strength of association was assessed by the odds ratio and respective 95% confidence intervals. For the qualitative part, 18 participants were selected purposively for in-depth interviews, an interviewer guide was used for data collection and thematic content analysis was performed.
Results: In this study, a total of 702 pregnant women were included with the response rate of 100%. The rate of COVID-19 vaccine acceptance was 22.6% (95% CI: 19.6%, 25.9%). The husbands' educational level (AOR = 1.99, 95% CI: 1.09, 3.64), chronic medical illness (AOR = 2.41, 95% CI: 1.28, 4.54), positive attitude (AOR = 1.59, 95% CI: 1.09, 2.31), and good practice of COVID-19 preventive measures (AOR = 1.59, 95% CI: 1.09, 2.31) were determinant factors of COVID-19 vaccine acceptance. According to the qualitative findings, the most common reasons for COVID-19 vaccine hesitancy were fear of fetal side effects, misconceptions about the vaccine, and religious beliefs.
Conclusion: In this study, the acceptability of the COVID-19 vaccine was low. Therefore, health professionals should disseminate accurate vaccination information and address misinformation to boost vaccine acceptance among pregnant women.

Introduction

COVID-19 has expanded to over 228 countries worldwide, causing a variety of severe issues that affect humanity, such as mortality and morbidity, as well as social and economic challenges.1,2 According to the World Health Organization (WHO) Coronavirus (COVID-19) Dashboard, as of December 27, 2021, there have been 290, 726,856 confirmed cases and 5,459,051 deaths reported worldwide, and in Ethiopia, 424,750 confirmed cases and 6947 deaths were reported.3 Findings from the WHO collaborating center for global women’s health show that COVID-19 was found in 9% of pregnant women who were admitted for any reason.4 According to a survey from Mexico, COVID-19 was the cause of 22.93% of maternal deaths.5 According to a study conducted in Iran, 7 of 9 pregnant women with severe COVID-19 disease died at the time of reporting, 1 of 9 was extremely ill and on a ventilator, and 1 of 9 recovered after protracted hospitalization.6

Pregnant women are known to be vulnerable to COVID-19 infection and are at risk of getting severe respiratory infections due to physiologic changes in their respiratory and immune systems.7,8 It has been observed that the clinical course of COVID-19 infection in pregnant women is worse than in non-pregnant women, which means that pregnant women with COVID-19 are more likely to require hospitalization, intensive care, and invasive ventilation to help with breathing.9–11 Pregnant women with severe and critical diseases had a higher rate of cesarean delivery, an increased risk for preterm birth, and pregnancy loss.12,13 Preventing critical COVID-19 infection is thus critical for both mother and child.

As studies indicate, vaccination against COVID-19 reduces the overall infection rate of COVID-19 and reduces deaths and hospitalization due to COVID-19 infection.14,15 Increasing evidence on the safety and effectiveness of COVID-19 vaccination during pregnancy suggests that the benefits of vaccination during pregnancy outweigh potential risks whenever there is ongoing or anticipated community transmission of the virus.9 WHO recommends that pregnant women should receive a vaccine against COVID-19.9 The American College of Obstetricians and Gynecologists (ACOG) also strongly recommends that pregnant individuals be vaccinated against COVID-19.16 The Society of Obstetricians and Gynecologists of Canada (SOGC) also recommends that all pregnant women should be prioritized to receive a COVID-19 vaccination.17

Studies suggested that having less knowledge about the COVID-19, more false perceptions or a poor attitude toward the COVID-19 vaccine, and not being willing to take the vaccine were the identified barriers to taking the COVID-19 vaccine.18–21 To improve COVID-19 vaccine uptake among pregnant women, it’s critical to first identify the obstacles to usage, which includes examining the socio-cultural factors that influence pregnant women’s refusal to take the vaccination.

As far as our knowledge, information on COVID-19 vaccine acceptance among pregnant women is limited in Ethiopia, and no studies have been conducted in the study area. Therefore, we aimed to determine the prevalence of COVID-19 vaccination acceptability and the factors that influence it among pregnant women in Northeast Ethiopia. We also attempted to examine the socio-cultural factors of COVID-19 vaccine hesitancy using qualitative analysis. In order to effectively enhance the uptake of the COVID-19 vaccine, the finding will help policymakers, health authorities, and other stakeholders establish targeted immunization campaigns and evidence-based recommendations.

Methods and Materials

Study Design and Setting

An institutional-based cross-section mixed-methods approach comprising both qualitative interviews and a quantitative survey was conducted from January 1–30, 2022 in public hospitals in the South Wollo Zone. South Wollo is one of the 12 zones in the Amhara Region of Ethiopia. There are 12 public hospitals in the south Wollo zone, namely: Mekaneselam Hospital, Hidar 11 Hospital, Nigist Zewditu Hospital, Jama Hospital, Haik Hospital, Tenta Hospital, Wegidi Hospital, Mekidela Hospital, Saint Hospital, Delanta Hospital, and Kelala Hospital Kombolcha General Hospital. These hospitals serve a population of 2,243,013.22

Population

All pregnant women attending antenatal care at South Wollo Zone public hospitals were the source population, whereas, pregnant women who were found in selected hospitals during the data collection period were the study population.

Eligibility Criteria

All pregnant mothers who were attending antenatal care follow-up at public hospitals in the south Wollo zone during the data collection period were included.

Sample Size Determination and Sampling Technique

The required sample size (n) for the quantitative part of the study was determined using a single population proportion formula considering the following assumptions: P = 70.7% of respondents in Southwest Ethiopia accepted the COVID-19 vaccine;23 confidence level (Z) = 95%; 5% margin of error (d); n=Z2/2 n=(1.96)2.707x 0.293/(.05)2 = 319. By considering a 10% non-response rate and a design effect of two, the final sample size for this study was 702. For the qualitative part, 18 participants were included in the study based on information saturation. A multistage sampling technique was employed to select study participants for the quantitative parts of the study. There are twelve public hospitals in South Wollo; five public hospitals (42%) were selected by a simple random sampling technique, namely, Haik primary hospital, Hidar 11 general hospital, Mekaneselam General Hospital, Nigist Zewdidu primary hospital, and Jama Hospital. The numbers of study participants for each hospital were estimated proportionally based on the hospital’s monthly average case flow by taking three consecutive months. Finally, the study participants were selected by a systematic random sampling method. For the qualitative parts of the study, the study participants were recruited purposively until data saturation was achieved.

Data Collection Procedure

For the qualitative parts of the study, face-to-face interviews with a pretested structured questionnaire were used to collect data. The questionnaire was adapted from previous similar literature23–28 and it includes information related to socio-demographic characteristics, medical and obstetric characteristics, knowledge, attitude, and practice of respondents on COVID-19 preventive measures, and the intention of COVID-19 vaccine acceptance among pregnant women. Five trained degree midwives used the Amharic version of the questionnaire to collect the data. In-depth interviews were conducted by the investigators for the qualitative part of the study.

Data Quality Control

The questionnaire was prepared originally in English and was translated into Amharic (the local language) and back to English by two independent persons to maintain the consistency of the questionnaire. The training was given to data collectors and supervisors. A pre-test was conducted using 5% of the questioners at Kemissie General Hospital and a necessary modification was made before the actual data collection.

Data Processing and Analysis

Before entering the data into Epi Data version 4.6 for the quantitative portion of the study, the collected data were checked for completeness and consistency. For analysis, the data was exported to SPSS version 25 software. The exported data was categorized and summarized using descriptive statistics like frequency tables, graphs, and proportions. Then bivariate analysis was carried out to assess the crude association between the independent and outcome variables. The variables with a P-value <0.2 in bivariate analysis were entered into a multivariable logistic regression to assess the net effect by controlling confounders. The variables with p < 0.05 in multivariable logistic regression were considered statistically significant factors for the knowledge and desire of antenatal clients about labor companions. The adjusted odds ratio (AOR) with a 95% confidence interval (CI) was used to assess the strength of the association. For the qualitative parts of the study, the data analysis was initiated by transcription and translation of the interviews, then coded and analyzed by thematic analysis.

Operational Definition

Vaccine Acceptance

COVID-19 vaccine acceptance was measured using “Yes” and “No” questions. Respondents were asked, “If the COVID-19 vaccine is available, are you willing to take it?” Those who answered “yes” received a score of 1, while those who answered “no” received a score of 0. Accordingly, respondents who scored 1 were thought of as having an intention to accept the COVID-19 vaccine and respondents.29

Knowledge About COVID-19

The respondents’ level of knowledge about COVID-19 was reported as good knowledge if the study participant correctly responded to more than or equal to 80% of the knowledge assessment tools, and poor for <80%.23

Attitudes Towards COVID-19

The participant’s attitude was classified as positive or favorable if they responded positively to more than 80% of the attitude-related items and negative if they responded negatively to less than 80% of the attitude-related items.23

The Practice of COVID-19 Preventive Measures

The respondents’ level of practice of COVID-19 preventive measures was reported as “good practice” if the study participant correctly responded to more than or equal to 80% of the practice assessment tools, and poor for 80%.23

Ethical Consideration

The study was carried out in accordance with the Helsinki Declaration. The research team confirm that this research caused no harm (physical or mental) to any participants. Ethical clearance was obtained from Wollo University, College of Medicine and Health Sciences Ethical Review Committee. A letter of cooperation was obtained from the South Wollo zone health office. The research process complies with the Declaration of Helsinki. Written consent was obtained from individual respondents. Information on the study was explained to the study participants, including the objective, procedure, and benefit of the study. The respondents were informed that they have the right to refuse or decline participation in the study at any time. The participants’ confidentiality was secured throughout the study, and information regarding the identification of the patient was recorded anonymously.

Results

Quantitative

Socio-Demographic Characteristics

A total of 702 pregnant women were interviewed successfully, making a response rate of 100%. Of those, 622 (88.6%) respondents were in the age range of 20–34 years. The great majority (98.4%) of the study participants were married. More than half (69.9%) of the respondents were Muslim, followed by Orthodox Christians (28.8%). Regarding educational status, 384 (54.7%) of the study subjects had completed secondary school and above. The majority of the respondents (62.8%) lived in urban areas (Table 1).

Table 1

Socio-Demographic Characteristics of the Respondents in South Wollo Northeast Ethiopia, 2022

Characteristics	Frequency	Percentage
Age the mother
<20	19	2.7%
20–34	622	88.6%
35–49	61	8.7%
Marital status
Single	7	1%
Married	691	98.4%
Divorced	4	0.6%
Religion
Orthodox	202	28.8%
Muslim	491	69.9%
Protestant	6	0.9%
Catholic	3	0.4%
Place of residence
Urban	441	62.8%
Rural	261	37.2%
Educational level
No formal education	156	22.2%
Primary school	162	23.1%
Secondary School and above	384	54.7%
Occupational status
Housewife	103	14.7%
Government employee	216	30.8%
Farmer	181	25.8%
Student	57	8.1%
Merchant	145	20.7%
Husbands educational level
No formal education	142	20.2%
Primary education	205	29.2%
Secondary education	168	23.9%
Diploma and above	187	26.6%
Husbands occupational status
Government Employee	272	38.7%
Private employee	194	27.6%
Merchant	109	15.5%
Student	69	9.8%
Farmer	58	8.3%

Maternal Medical and Obstetric Related Characteristics

The majority of the responders, 507(72.2%), were multigravida. The second antenatal care appointment was attended by around a quarter of the respondents (34.6%). A percentage of the respondents (7.3%) had a medical history. In terms of medical conditions, 18 (35.3%) had a history of hypertension, followed by diabetes mellitus (27.5) (Table 2).

Table 2

Medical and Obstetrics Related Characteristics of Respondents in South Wollo Northeast Ethiopia, 2022

Characteristics	Frequency	Percentage
Gravidity
Primigravida	195	27.8%
Multigravida	507	72.2%
ANC visit
1st Visit	226	32.2%
2nd visit	243	34.6%
3rd visit	165	23.5%
4th visit	68	9.7%
Medical illness
Yes	51	7.3%
No	651	92.7%
Types of medical illness
Hypertension	18	35.3%
Diabetic Mellitus	14	27.5%
Kidney disease	8	15.7%
Asthma	9	17.6%
Cardiac disease	2	3.9%
ANC= Antenatal care

Knowledge of the Pregnant Women About COVID-19

All of the 702 study participants (100%) reported that they had ever heard about the coronavirus pandemic. The majority (81.6%) of the pregnant women responded that they knew at least one common symptom of COVID-19 infection. Eighty-eight percent of all respondents were aware that COVID-19 currently has no effective treatment, and 98.6% were aware that COVID-19 can infect anyone (Table 3).

Table 3

Knowledge of Pregnant Women About COVID-19 in Northeast Ethiopia, 2022

No	Variables	Yes (%)	No (%)
1	Heard about COVID-19	702(100%)	0(0%)
2	Re-infection can occur with COVID-19	490(69.8%)	212(30.2%)
3	COVID-19 has effective treatment presently	84(12.0%)	618(88.0%)
4	Do you know the symptom of COVID-19 infection	573(81.6%)	129(18.4%)
5	Everybody can be infected by COVID-19	692(98.6%)	10(1.4%)
6	COVID-19 is severe in Co-morbid and elderly people	451(64.2%)	251(35.8%)
7	Avoiding crowding can decrease the risk of COVID-19	656 (93.4%)	46(6.6%)
8	Avoiding touching eyes and nose prevents COVID-19	680 (96.9%)	22(3.1%)
9	COVID-19 infection can be transmitted by air droplets	699(99.6%)	3(0.4%)
10	Ordinary people should use the mask to prevent COVID	668(95.2%)	34(4.8%)
11	Isolation is important after contact with an infected person	619(88.2%)	83(11.8%)
12	Reporting the suspected symptom is recommended	626(89.2%)	76 (10.8%)

Attitude and Perception Toward COVID-19

The great majority (90.3%) of study participants thought that COVID-19 infection increases in crowding and gatherings. Most of them (82.8%) believe that health education can protect against COVID-19. More than half (65.4%) of the respondents believe that disinfection of the public and buildings protects against COVID-19 (Table 4).

Table 4

Attitude of Respondents Towards COVID-19 Infection in South Wollo Northeast Ethiopia, 2022

No	Variables	Agree	Disagree
1	COVID-19 infection increases in crowding and gatherings	634(90.3%)	68(9.7%)
2	Health education can protect against COVID-19	581(82.8%)	121(17.2%)
3	Disinfection of the public and buildings protect against COVID-19	459(65.4%)	243(34.6%)
4	Country instructions are taken to limit the spread of COVID-19	550(78.3%)	152(21.7%)
5	Country instructions are enough	467(66.5%)	235(33.5%)
6	All people are committed to the country’s instructions	528(75.2%)	174(24.8%)
7	COVID-19 will be contained soon	349(49.7%)	353(50.3%)

The women’s responses regarding the practice of preventive measures against COVID-19 infection were frequent handwashing with water and soap (94.6%), covering the mouth with an elbow while sneezing (81.9%), wearing a face mask when going out (47.4%), keeping a physical distance (54.6%), and avoiding going to social gatherings (52.8%) (Table 5).

Table 5

Practice of COVID-19 Preventive Measures Among Pregnant Women in Northeast Ethiopia, 2022

No	Practice Question	Yes	No
1	Wash hand with soap/use sanitizer	664(94.6%)	38(5.4%)
2	Covering mouth with an elbow while sneezing	575(81.9%)	127(18.1%)
3	Wearing a face mask when going out	333(47.4%)	369(52.6%)
4	Reporting COVID-19 symptoms to the health facility	547(77.9%)	155(22.1%)
5	Keeping physical distancing	383(54.6%)	319(45.4%)
6	Avoiding going to the social gathering	528(75.2%)	174(24.8%)
7	Staying at home /working from home	136(19.4%)	566(80.6%)
8	Changing travel	423(60.3%)	279(39.7%)
9	Stop handshaking with people	304(43.3%)	398(56.7%)
10	Health care seeking when getting ill	542(77.2%)	160(22.8%)

COVID-19 Vaccine Acceptance Among Pregnant Women

The COVID-19 vaccine acceptance if it is available was found to be 22.6% (95% CI; 19.6–25.9%). While (77.4%) of pregnant women refused to use the COVID-19 vaccine (Figure 1), The highest number (40.3%) of COVID-19 vaccine hesitance was because the respondents believed that the COVID-19 vaccine would harm their fetus, followed by fear of side effects and risks (31.9%) (Figure 2).

Figure 1

COVID-19 vaccine acceptance among pregnant women in northeast Ethiopia, 2022.

Figure 2

Reason for COVID-19 vaccine hesitance among pregnant women Northeast Ethiopia, 2022.

Determinants of COVID-19 Vaccine Acceptance Among Pregnant Women

Bivariate and multivariate logistic regression analyses were done to identify factors associated with the COVID-19 vaccine acceptance among pregnant women. The bivariate analysis reveals that urban residence, woman’s educational level, husbands educational level, gravidity, history of chronic medical illness, attitude towards COVID-19 and practicing COVID-19 preventive measures were found to have association with COVID-19 vaccine acceptance. After controlling for potential confounds in multiple logistic regression analyses, the husband’s educational level, women’s medical illness, attitude towards the COVID-19 infection, and practicing COVID-19 prevention measures were found to be determinants for COVID-19 vaccine acceptance.

As a result, women whose husband’s educational level was a diploma or above were 1.99 times more likely to accept the COVID-19 vaccine compared to their counterparts (AOR = 1.99, 95% CI: 1.09, 3.64). Pregnant women who had a history of medical illness were 2.41 times more likely to accept the COVID-19 vaccine compared to their counterparts (AOR = 2.41, 95% CI: 1.28, 4.54). Similarly, pregnant women who had a positive attitude towards the COVID-19 pandemic were 1.59 times more likely to accept the COVID vaccine as compared to those women who had negative attitudes (AOR = 1.59, 95% CI: 1.09, 2.31). Pregnant women who practiced COVID-19 prevention methods well were 1.94 times more likely to accept the COVID-19 vaccine than those who practiced COVID-19 prevention methods poorly (AOR = 1.94, 95% CI: 1.31, 2.85) (Table 6).

Table 6

Determinants of COVID-19 Vaccine Acceptance Among Pregnant Women in Northeast Ethiopia, Multivariate Logistic Regression Model, 2022

Variables	COVID-19 Vaccine Acceptance		COR(95% CI)	AOR(95% CI)
	Yes (%)	No (%)
Residence
Urban	112(25.4)	329 (74.6)	1.55(1.06, 2.27)*	0.88(0.51, 1.49)
Rural	47(18.0)	214(82.0)	1	1
Maternal educational level
No formal education	22(14.1)	134(85.9)	1	1
Primary school	35(21.6)	127(78.4)	1.68(0.93, 3.02)	1.77(0.97, 3.24)
Secondary and above	102(26.6)	282(73.4)	2.2(1.33, 3.65)*	1.53(0.84, 2.82)
Husbands educational level
No formal education	25(17.6)	117(82.4)	1	1
Primary school	37(18.0)	168(82.0)	1.03(0.59, 1.80)	1.08(0.59, 1.96)
Secondary school	38(22.6)	130(77.4)	1.37(0.78, 2.40)	1.18(0.64, 2.18)
Diploma and above	59(31.6)	128(68.4)	2.16(1.27, 3.67)*	1.99(1.09, 3.64)*
Gravidity
Primigravida	36(18.5)	159(81.5)	1	1
Multigravida	123(24.3)	384(75.7)	1.42 (1.12, 2.14)*	1.44(0.92, 2.27)
Chronic medical illness
Yes	20(39.2)	31(60.8)	2.38(1.31, 4.29)*	2.41(1.28, 4.54)*
No	139(21.4)	512(78.6)	1	1
Attitude
Positive attitude	80 (28.0)	206(72.0)	1.66(1.16, 2.36)*	1.59(1.09, 2.31)*
Negative attitude	79(19.0)	337(81.0)	1	1
Practice
Good practice	78(28.0)	201(72.0)	1.64(1.15, 2.34)*	1.94(1.31, 2.85)**
Poor practice	81(19.1)	342(80.9)	1	1

Note: **p-value<001, *p-value<0.05, 1=reference.

Abbreviations: COR, Crud odds ratio; AOR, Adjusted odds ratio.

Qualitative

Socio-Demographic and Obstetric Characteristics of the Respondents

Eighteen participants were included for an in-depth interview on the reasons for not accepting the COVID-19 vaccine. About fifty-six percent of the respondents were in the age group of 20–34 years old. A majority (77.8%) of the study subjects were Muslim, and 72.2% of the respondents lived in urban areas. All of the participants were married. Half of the study participants (50%) attained secondary and above educational levels, followed by elementary school. Regarding their occupational status, 44.4% were government employees, followed by merchants (27.8%). About seventy-two percent of the study subjects were multigravida and nearly half (46.2%) of them were multiparous. About a quarter (33.3%) and (27.8%) of the respondents were coming for their second and third visit at the time of the interview.

Reason for Not Accepting the COVID-19 Vaccine

Pregnant women who come for antenatal care visits were selected for the in-depth interview purposively. Those respondents who answered “no: to the question “are you willing to take the COVID-19 vaccine if it is available?” were included in an in-depth interview on the reason for COVID-19 vaccine hesitance. Study participants are concerned that the COVID-19 vaccine may harm their fetus. They said,

I am scared that the vaccine will pass to my baby and my baby will die. My baby couldn’t resist the side effects. (Participant # 1, 3, 7, 11, 15 and 16).

Some of the participants believe that the risk of getting COVID is low and they believe that Allah will keep them from any risks. They said,

I believe my risk of getting COVID is low because none of my relatives have been infected with COVID up to this point. I am a firm believer in Allah. Allah will protect my family and me from infection. (Participant # 4, 9, and 17)

some said,

I am not afraid because I expected this to happen; we brought this on ourselves and we are paying for our sins. We must pray, believe in, and obey our Creator. (Participant # 6, 12, and 14).

Others have insufficient information on the benefits and safety of the COVID-19 vaccine for pregnant women. They said,

I don’t have sufficient information about the vaccine and whether it is safe for me and my baby. During my antenatal care visit, my health care professional says nothing about the vaccine. (Participant # 2, 5, and 8).

Some pregnant women are afraid of injections and do not believe in the vaccine. They said, “I’m afraid of the injection and don’t believe the vaccine. I feel the vaccine contained a chemical that could affect my reproductive ability”. (Participants # 10 and 18).

A 32 years participant also believes that the side effects of the COVID-19 vaccine will make them ill. She said,

I know that one of my neighbors stayed in bed for 2 weeks after she took the vaccine. I think the vaccine would make me ill if I took it as my neighbor. (Participant # 13)

Discussion

The viral disease COVID-19 has adverse effects on pregnant mothers and their unborn fetuses.30–33 In the event of a breakthrough infection, vaccination will reduce the severity of the illness and lower the likelihood of acquiring COVID-19.16,34–36 The safety of delivering the currently available SARS-CoV-2 vaccines before, during, and after pregnancy is supported by all available research.37,38 However, vaccine hesitancy becomes one of the greatest challenges globally.39–41

In this study, the overall COVID-19 vaccine acceptance among pregnant women was substantially low (22.6%) with a 95% confidence interval of 19.6% to 25.9%. This finding is in line with a recent finding in Debre Markos, Northwest Ethiopia (18.5%).42 However, the acceptance rate in our study was lower than studies conducted in southwest Ethiopia (70.7%),23 Northwest Ethiopia (40.08%),29 Northern Nigeria (33.8%),43 Singapore(30.5%),44 Thailand (60.8%),25 Saudi Arabia (68%)45 and China (77.4%)46 and Czechia (76.6%)47 and low-and middle-income countries (80.3%).28 The possible explanations for these differences are differences in sample size, study setting, and study population differences.

The current study shows that pregnant women whose husband’s educational level was a diploma or above were 1.99 times more likely to accept the COVID-19 vaccine compared to their counterparts. The possible explanation might be that those husbands who had attain higher educational level could read the news and follow social media related to the COVID-19 virus’s impact on the general population and its fatality and will share the information to their wives. However, this finding contradicts the previous study conducted in northwest Ethiopia.29 The difference may be due to the difference in sample size, in which the sample size of the current study was nearly double that of the study conducted in northwest Ethiopia.

Pregnant women who have chronic medical illnesses were 2.41 times more likely to accept the COVID-19 vaccine as compared with healthy participants. This is supported by the studies done in Ethiopia.23,42 The most important justification Perhaps people with chronic medical illnesses are more afraid of the COVID-19 pandemic because they know more about COVID-19ʹs behavior, which has a greater impact on patients with chronic health problems. Women’s attitude toward the COVID-19 infection was assessed and the finding reveals that 40.7% of respondents had a positive attitude towards the COVID-19 pandemic, which was lower than studies conducted in southwest Ethiopia (66.7%).23 The finding also shows that pregnant women who had a positive attitude toward the COVID-19 were 1.59 times more likely to accept the COVID vaccine as compared to those women who had a poor attitude. The finding was in line with a previous study conducted in northwest Ethiopia in which women who had a favorable attitude towards the COVID-19 pandemic were 8.54 times more likely to accept the vaccine.29 However, this finding was contrary to a previous study conducted in southwest Ethiopia.23 The difference may be due to the difference in sample size.

Similarly, the findings of this study reveal that 39.7% of pregnant women had good practice toward COVID-19 preventive measures, which was lower than studies conducted in southwest Ethiopia (61.4%) and Wollega Zones, Ethiopia (43.6%). Pregnant women who had good practice of COVID-19 prevention methods were 1.94 times more likely to accept the COVID-19 vaccine compared to those women who practiced the preventive measure of COVID-19 poorly. The current study’s findings were consistent with a study conducted in southwest Ethiopia.23 This study had the drawback of not proving the cause-and-effect link because of its cross-sectional design.

Conclusion

The COVID-19 vaccination was found to have low acceptance among pregnant women in this investigation. Acceptance of the COVID-19 vaccine, assuming it becomes available, was connected with the husband’s higher educational level, chronic medical illness, positive views regarding the COVID-19 pandemic and good practice of the COVID-19 infection prevention strategy. Health care providers and health extension workers in collaboration with the zonal and regional health bureaus should pay extensive attention to the dissemination of accurate vaccination information and address misinformation to boost vaccine acceptance among pregnant women.