Ryan Duong1, Xiaoyu Cai2, Naveen Ambati2, Yevgeniy Shildkrot3, Rebecca Sieburth4. 1. University of Virginia Department of Ophthalmology, 1300 Jefferson Park Ave., Charlottesville, VA, 22903, USA. rtd6bp@hscmail.mcc.virginia.edu. 2. University of Virginia School of Medicine, 200 Jeanette Lancaster Way, Charlottesville, VA, 22903, USA. 3. University of Virginia Department of Ophthalmology, 1300 Jefferson Park Ave., Charlottesville, VA, 22903, USA. 4. Northeast Eye Center, 713 Troy Schenectady Rd, Latham, NY, 12110, USA.
Abstract
BACKGROUND/ OBJECTIVE: Asteroid hyalosis (AH) is an uncommon clinical entity of unknown aetiology that is associated with older age. Previous epidemiologic studies have reported various systemic and demographic risk factors for AH but remain limited due to regional constraints of their study populations. Additionally, Hispanic and Non-Hispanic black populations remain under sampled. The aim of this study is to examine the prevalence of asteroid hyalosis in the United States and identify associated factors at a national level. SUBJECTS/ METHODS: This is a population-based, cross-sectional study of 5578 subjects aged 40 and older from the 2005 to 2008 National Health and Nutrition Examination Survey (NHANES). The primary outcome measured was asteroid hyalosis on retinal imaging in any eye. Evaluated risk factors included patient demographics, medical history, body measures, serum markers, and fundus photography findings. RESULTS: Prevalence of asteroid hyalosis was 0.86% overall, 0.86% in Caucasians, 0.79% in African-Americans, and 0.88% in Hispanics. Asteroid hyalosis was associated with older age (p < 0.0001, 95% confidence interval [CI], 0.06-0.12; odds ratio [OR], 1.09) but not ethnicity or sex. After adjusting for age, greater bodyweight (p = 0.049; 95% CI, 0.001-0.04; OR, 1.02), and history of myocardial infarction (p = 0.022; 95% CI, 0.07-1.55; OR, 2.36) were also found to be significant risk factors. CONCLUSION: Asteroid hyalosis is a rare entity in the US associated with older age, greater body weight, and prior history of MI. A potential relationship between AH and cardiovascular disease remains plausible.
BACKGROUND/ OBJECTIVE: Asteroid hyalosis (AH) is an uncommon clinical entity of unknown aetiology that is associated with older age. Previous epidemiologic studies have reported various systemic and demographic risk factors for AH but remain limited due to regional constraints of their study populations. Additionally, Hispanic and Non-Hispanic black populations remain under sampled. The aim of this study is to examine the prevalence of asteroid hyalosis in the United States and identify associated factors at a national level. SUBJECTS/ METHODS: This is a population-based, cross-sectional study of 5578 subjects aged 40 and older from the 2005 to 2008 National Health and Nutrition Examination Survey (NHANES). The primary outcome measured was asteroid hyalosis on retinal imaging in any eye. Evaluated risk factors included patient demographics, medical history, body measures, serum markers, and fundus photography findings. RESULTS: Prevalence of asteroid hyalosis was 0.86% overall, 0.86% in Caucasians, 0.79% in African-Americans, and 0.88% in Hispanics. Asteroid hyalosis was associated with older age (p < 0.0001, 95% confidence interval [CI], 0.06-0.12; odds ratio [OR], 1.09) but not ethnicity or sex. After adjusting for age, greater bodyweight (p = 0.049; 95% CI, 0.001-0.04; OR, 1.02), and history of myocardial infarction (p = 0.022; 95% CI, 0.07-1.55; OR, 2.36) were also found to be significant risk factors. CONCLUSION: Asteroid hyalosis is a rare entity in the US associated with older age, greater body weight, and prior history of MI. A potential relationship between AH and cardiovascular disease remains plausible.
Authors: Sadiya S Khan; Hongyan Ning; John T Wilkins; Norrina Allen; Mercedes Carnethon; Jarett D Berry; Ranya N Sweis; Donald M Lloyd-Jones Journal: JAMA Cardiol Date: 2018-04-01 Impact factor: 14.676