| Literature DB >> 3603638 |
Abstract
In an organism with a life-cycle modelled on that of Plasmodium two separate resistance genes are assumed, each protecting against one of two unrelated drugs. The model was used to compare the rates of build-up of resistance in a population where the two drugs are used either as a mixture or in sequence. The model suggests that the use of a mixture would be advantageous if: both resistances are initially rare; there is recombination between the genes; a large proportion of the parasite population is unexposed to the drugs.Mesh：
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Year: 1986 PMID： 3603638 DOI： 10.1016/0035-9203(86)90248-8
Source DB: PubMed Journal: Trans R Soc Trop Med Hyg ISSN： 0035-9203 Impact factor: 2.184