Observation on the Effect of High-Quality Nursing Intervention plus Health Education in Chemotherapy for Non-Small Cell Lung Cancer and Its Influence on the Physical and Mental Health of Patients.

Objective: The objective is to analyze the effect of high-quality nursing intervention combined with health education in the chemotherapy for non-small cell lung cancer and its impact on the physical and mental health of patients.
Methods: The study included 136 patients with non-small cell lung cancer treated at our hospital from March 2020 to December 2021, who were divided into the observation group and the routine/control group by randomization, with 68 patients in each. All patients received the GP (gemcitabine + cisplatin) chemotherapy. The control group received routine nursing care, whereas the observation group received high-quality nursing care mixed with health education. The effect of nursing intervention, patient self-management, and the influence on the physical and mental health of the patients was compared between the two groups.
Results: The total efficacy rate (89.71%) of the observation group was significantly higher than that of the routine group (57.35%) (P < 0.05). The self-management level of the patients in the observation group, indicated by the Exercise of Self-Care Agency (ESCA) score, was considerably higher than that of the regular group after nursing intervention. Similarly, the observation group's quality of life, which was evaluated in terms of physical function, role function, emotional function, cognitive function, social function, and overall health status, was much better than the routine group's. Furthermore, the SAS, SDS, and overall incidence of adverse events were lower in the observation group than in the regular group. (P < 0.05).
Conclusion: The application of high-quality nursing intervention combined with health education in chemotherapy for non-small cell lung cancer has favorable clinical benefits, enhances patient compliance and self-management capacity, and exerts a positive influence on the patient's physical and mental health. Adverse reactions can provide a more trustworthy scientific basis for therapeutic therapy. The method should be widely used.

1. Introduction

Non-small cell lung cancer (Non-small cell lung carcinoma) (NSCLC) [1] is a malignant tumor, accounting for about 80–85% of all lung cancer cases. NSCLC originates from the bronchial mucosa, bronchial glands, and alveolar epithelium, defined by the light microscope. It is constituted by nuclear atypia, large cells, and abundant cytoplasm [2, 3]. According to the 2013 Lung Cancer Review Report [4], lung cancer ranks first in new cases and is the leading cause of cancer-related deaths, among which NSCLC accounts for about 85% of all lung cancer types. The morbidity and mortality rates among men are higher than those among women. NSCLC is classified histopathologically as adenocarcinoma, squamous cell carcinoma, adenosquamous cell carcinoma, big cell carcinoma, and nodular carcinoma [5]. With the comparatively slow apparent diffusion, NSCLC cancer cells develop and divide at a slower speed than small cell carcinoma [6].

Relevant clinical studies have related the symptoms of NSCLC to the location of the primary tumor and its metastasis. The early symptoms are relatively mild and gradually aggravate as the disease progresses, mainly including chest pain, blood in the sputum, low-grade fever, cough, etc. Symptoms include fatigue, weight loss, loss of appetite, and other local symptoms such as shortness of breath, cough, and hemoptysis [7]. NSCLC is a highly prevalent type of cancer. If patients experience a prolonged cough or inexplicable sputum with blood, hemoptysis, or inenarrable chest discomfort, they should seek medical help as soon as possible. It requires early detection, early diagnosis, and early treatment. Chemotherapy is the primary treatment for lung cancer; more than 90% of lung cancers require chemotherapy in early and advanced stages, with the tumor remission rate reaching 40–50% [8]. Clinically, different chemotherapy drugs and chemotherapy regimens should be selected according to different histological types of lung cancer [9]. In clinical chemotherapy, gemcitabine and cisplatin are commonly utilized. To destroy cancer cells and boost the efficacy of chemotherapy, a combination of Gemcitabine and Cisplatin is usually required. Nonetheless, chemotherapy, nonselective as it is, can take a toll on both healthy and normal tissues, resulting in severe adverse responses. [10, 11].

Chemotherapy can help inhibit the progression of tumor lesions and prolong the survival time of patients, yet it is subject to such factors as adverse reactions and lung cancer lesions, which can easily stimulate a variety of negative emotions in patients and have an impact on their quality of life. Studies have shown that most NSCLC patients, especially those in the advanced stage, are prone to a series of nursing problems and serious psychological problems during chemoradiotherapy, resulting in the severe retrogression of the therapeutic efficacy and their quality of life [12]. Therefore, the application value of nursing intervention in concurrent chemoradiotherapy for patients with advanced NSCLC has attracted widespread attention. High-quality nursing is to provide nursing services that can accommodate the specific needs of patients on the basis of routine nursing, guided by the “people-oriented” principle and taking into consideration the actual conditions of patients, aiming to improve the quality of clinical nursing care [13]. In addition, lung cancer patients have a high degree of unsatisfied demand for disease-related information during treatment. At present, health education is the main method to meet patients' demand for information in clinical practice. Providing patients with information support can strengthen their awareness of self-care and improve their quality of life [14]. Therefore, this study observed the effect of high-quality nursing intervention combined with health education in chemotherapy for patients with non-small cell lung cancer and its impact on their physical and mental health.

2. Methodology

2.1. Research Subject

From March 2020 to December 2021, 136 NSCLC patients were treated at our institution and divided into two groups by randomization: the observation group and the routine/control group, each with 68 patients. The randomization was carried out using an online web-based tool (freely available at https://www.randomizer.org/). For concealment of allocation, the randomization procedure and assignment were managed by an independent research assistant who was not involved in screening or evaluating the participants.

The original sample size calculation estimated that 60 patients in each group would be needed to detect a 3-point difference between groups in a 2-sided significance test with a power of 0.8 and an alpha error level of 0.05.

All patients were treated with GP (gemcitabine + cisplatin) chemotherapy regimen. Among the patients, there were 77 males and 59 females aged 42–75, with an average age of 50.23 ± 6.18 years.

Before inclusion, informed consent was obtained from the patients, who signed the informed consent forms. This study protocol was approved by the hospital ethics committee, No. SD-EU20200405. All procedures comply with the ethical guidelines on clinical research of the Declaration of Helsinki.

2.2. Inclusion and Exclusion Criteria

2.2.1. Inclusion Criteria

(1) All patients met the relevant clinical diagnostic criteria for non-small cell lung cancer with proper pathological examinations. (2) All patients had a survival rate for more than 3 months. (3) Patients and their families were informed of the purpose of the study and voluntarily signed the informed consent forms.

2.2.2. Exclusion Criteria

(1) NSCLC patients with severe organ dysfunction; (2) Allergic constitution or patients with an allergic response to the drugs used in the study, past allergy history or related treatment contraindications; (3) Patients with abnormal mental state and those unable to communicate normally; (4) Pregnant or breastfeeding women; (5) Those with severe liver and kidney dysfunction; (6) Those with severe diabetes complications; and (7) Those with mental illnesses such as depression or Alzheimer's.

2.3. Methods

All patients were subjected to GP (gemcitabine + cisplatin) chemotherapy regimen as follows: The initial dose administered on the 1st day was 500 ml of 0.9% sodium chloride injection (national medicine Zhunzi: H20153227, Hubei Kelun Pharmaceutical Co., Ltd.), mixed with 75 mg/m2 cisplatin injection (national medicine Zhunzi: H20043888, Yunnan Bio Valley Pharmaceutical Co., Ltd.) delivered intravenously for 2–3 hours. Another dose delivered on the 1st and 8th days of the 21-day cycle includes the intravenous drip containing 100 ml of 0.9% chlorine and 1000 mg/m2 gemcitabine in sodium injection (Guoyao Zhunzi: H20153227, Hubei Kelun Pharmaceutical Co., Ltd.) (21 days as a treatment cycle, a total of 4 cycles).

The routine group was subjected to routine nursing interventions, which include informing patients of relevant knowledge about the disease, taking appropriate preventive measures when admitted to the hospital, and monitoring the patients' phenotypic changes. In addition, routine nursing provides a comfortable hospitalization environment for the patients with improved patient sleep comfort and detailed instructions. Medicines were given to the patients on a timely basis and their adverse reactions were noted. [13, 14].

The observation group received high-quality nursing intervention combined with health education, as follows: (1) A professional team was established, which consisted of a head nurse, two experienced nurses, and several inpatient nurses. The nursing staff underwent comprehensive training on appropriate interventions. (2) Psychological nursing: The patient's psychological state was assessed and targeted psychological assistance was provided according to the conditions of the patient. Psychological nursing included the formulation of a comprehensive psychological intervention strategy, timely adjustment during the implementation process, the establishment of a sound doctor-patient relationship, the improvement of the patient compliance, confidence and self-control, and the motivation of the patient's enthusiasm in treatment. (3) Pain care: It was necessary to analyze the patient's pain intensity comprehensively to assess the conditions of the patient. Pain care included implementing individualized pain management, strengthening communication with the patient, and diverting the patient's attention, thereby relieving the pain. (4) Preventive care included protective measures for various adverse reactions that may occur during the treatment process. It also included advice on nutrition, assistance in cleaning and maintaining the body, and formulation of a proper rehabilitation training, with the patient's age and physical conditions are taken into consideration. (5) Health education: A responsible nurse was assigned to individually teach the patient about the ward environment, NSCLC, and disease management. The nurse also taught the patient to take in food within the acceptable range. (6) Education: By integrating the eating habits of the patient and the principles of an appropriate diet, a healthy diet plan was formulated, and at the same time, the patients were educated on developing good daily habits. Follow-up on the patients was conducted on a regular basis after discharge and the issues confronting them during self-monitoring were solved in a timely manner.

2.4. Evaluation Standard

2.4.1. Clinical Effect

With reference to “Evaluation Criteria for Treatment of Solid Tumors,” the clinical effect was classified into four levels: complete remission (CR), partial remission (PR), stable disease (SD), and disease progression (PD). CR refers to the disappearance of all clinical symptoms of tumors and the state of remission maintained for more than 1 month; PR refers to the sum of the maximum diameters of the lesions reduced by at least >30% and the state of partial remission maintained for more than 1 month; SD refers to neither sufficient shrinkage to qualify for PR nor sufficient expansion to qualify for PD. The sum of maximum lesion diameters was reduced by <30%, or increased by >20%; PD refers to the lesion volume increased by >20% compared with that before treatment or the appearance of a new lesion. Total efficacy rate=(CR + PR)/total number of cases x100%.

2.4.2. Compliance

The Exercise Compliance Scale established by our hospital was adopted to evaluate the compliance, which was divided into 3 grades on a 10-point scale: complete compliance (≥8 points), partial compliance (≥6 and < 8 points), and non-compliance (<6 points). The total treatment compliance of the two groups was calculated and compared using the following formula. Total compliance rate = (complete compliance + partial compliance)/total number of cases × 100%.

2.4.3. Self-Management

The Exercise of Self-Care Agency Scale (ESCA) [15] was used to evaluate the patient's self-management ability. ESCA scored from 0 to 172 points, classified into 4 sub-classes: self-concept with a full score of 32; self-care responsibility with a full score of 24; health knowledge level with a full score of 68 and self-care skills with a full score of 48 points. The score was directly proportional to the self-management ability, with higher scores indicating better self-management ability.

2.4.4. Physical and Mental Health

EORTC QLQ-C30, Self-Rating Anxiety Scale (SAS), and Self-Rating Depression Scale (SDS) [16] were used to evaluate the physical and mental health status of the patients, including 5 functional scales, 3 symptom scales, 6 general health items, and 1 specific item. The total score of each scale is 100 points, and the scores are proportional to the patient's quality of life, with higher scores indicating higher quality of life.

2.4.5. Adverse Reactions

The incidences of complications in response to the treatment regimen, including gastrointestinal reactions, skin and mucous membrane damage, bone marrow suppression, and a decrease in white blood cell count, were recorded in detail.

2.5. Statistical Analysis

GraphPad Prism 8 software was used to process images. SPSS 26.0 software was used as data analysis software, and the measurement data were expressed as (±s), tested with Independent samples t-test. The count data were expressed as number of cases (%) and tested by x2. P < 0.05 was considered statistically significant.

3. Results

3.1. Baseline Data

The routine group enrolled 68 patients, including 36 males and 32 females ranging in age from 42 to 75 years, with an average age of 50.59 ± 6.11 years. The illness lasted for 0.5–2 years, averaged at 0.71 ± 0.23 years. The educational levels of the patients in the routine group were as follows: high school degree or below (19), high school to a junior college degree (32), and bachelor's degree or above (17). The observation group enrolled 68 patients, including 41 males and 27 females aged 45–74 years, with an average age of 50.07 ± 6.21 years. The illness lasted for 0.5–2 years, averaged at 0.69 ± 0.25 years. The educational levels of the patients in the observational group included 18 cases with a high school degree or below, 34 cases with high school to junior college degree, and 16 cases with a bachelor's degree or above. There was no significant difference in clinical data between the two groups (P > 0.05), as shown in Table 1.

Table 1

Comparison of clinical data between the two groups of patients (±s).

Group	Number of cases	Gender		Age (years)		Disease course (years)		Educational level
		Male	Female	Range	Average	Range	Average	<High school	High school to college	>Undergraduate
Routine group	68	36	32	42–75	50.59 ± 6.11	0.5–2	0.71 ± 0.23	19	32	17
Observational group	68	41	27	45–74	50.07 ± 6.21	0.5–2	0.69 ± 0.25	18	34	16
t	—	—	—	—	0.492	—	0.485	—	—	—
P	—	—	—	—	0.624	—	0.628	—	—	—

3.2. Clinical Efficacy

The observation group included more cases of CR and PR (23, 38) than the conventional group (16, 23), however, the number of SD and PD cases (5, 2) was considerably smaller than that of the routine group (16, 13). The total clinical efficacy rate of patients in the observational group (89.71%) was substantially higher than that in the routine group (57.35%) (P < 0.05), as shown in Table 2.

Table 2

Comparison of clinical efficacy between the two groups after intervention (%).

Group	Number of cases	CR	PR	SD	PD	Total efficiency
Control group	68	16 (23.53)	23 (33.82)	16 (23.53)	13 (19.12)	39 (57.35)
Observational group	68	23 (33.82)	38 (55.88)	5 (7.35)	2 (2.94)	61 (89.71)
x 2	—	18.284
P	—	<0.001

3.3. Compliance

The number of patients in the observation group with complete and partial compliance (31, 36) was substantially greater than that in the routine group (20, 27), although the number of non-compliant patients (1) was significantly smaller than that in the routine group (11). Moreover, the total compliance rate of the patients in the observation group (98.53%) was higher than that in the control group (83.82%), (P < 0.05). Details are shown in Figure 1:

Figure 1

Comparison of compliance of the two groups of patients after the intervention. Note: indicates a statistically significant difference between the two groups, P < 0.05.

3.4. Self-Management

There was no significant difference in the self-management level between the two groups before the intervention (P > 0.05). Following the intervention, the patients in the observation group had considerably higher ESCA scores, in terms of self-concept, self-care responsibility, health knowledge level, and self-care abilities, compared with patients in the routine group (P < 0.05) (see Table 3).

Table 3

Comparison of ESCA scores between the two groups before and after intervention (±s).

Period	Dimension	Control group (n = 68)	Observational group (n = 68)	t	P
Before intervention	Self-control	15.59 ± 5.34	15.66 ± 5.24	0.077	0.939
	Self-care	13.68 ± 5.17	13.71 ± 5.31	0.033	0.974
	Health education level	21.01 ± 6.98	20.94 ± 7.03	0.058	0.954
	Self-care skills	18.89 ± 5.62	18.68 ± 5.97	0.211	0.833
After intervention	Self-control	21.56 ± 1.56∗	29.54 ± 1.61∗	29.353	<0.001
	Self-care	19.56 ± 1.01∗	23.87 ± 0.31∗	33.640	<0.001
	Health education level	50.59 ± 2.14∗	64.23 ± 2.34∗	35.471	<0.001
	Self-care skills	34.61 ± 3.25∗	43.88 ± 2.97∗	17.363	<0.001

3.5. Physical and Mental Health

3.5.1. Quality of Life

Following the intervention, patients in the observation group had significantly higher scores of quality of life, evaluated in terms of physical function, role function, emotional function, cognitive function, social function, and overall health status, than those in the routine group (P < 0.05), as shown in Table 4.

Table 4

Comparison of EORTC QLQ-C30 scores between the two groups after intervention (±s).

Dimensions	Control group (n = 68)	Observational group (n = 68)	t	P
Physical function	58.45 ± 9.32	78.05 ± 8.87	12.562	<0.001
Role function	69.45 ± 7.89	83.28 ± 7.26	10.637	<0.001
Emotional function	61.12 ± 8.48	80.98 ± 7.74	14.264	<0.001
Cognitive function	63.48 ± 5.11	83.23 ± 6.12	20.427	<0.001
Social function	61.21 ± 6.56	76.87 ± 6.89	13.574	<0.001
General health	64.28 ± 6.98	79.98 ± 7.50	12.636	<0.001

3.5.2. Emotional Management

The SAS and SDS scores of the observation group (39.58 ± 3.37, 44.28 ± 3.13) were lower than those of the routine group (52.41 ± 3.68, 58.05 ± 4.70) (P < 0.05)F, as shown in Figure 2.

Figure 2

Comparison of SAS and SDS levels between the two groups after intervention. Note: indicates a statistically significant difference between the two groups, P < 0.05.

3.6. Adverse Reactions

The number of cases of gastrointestinal reaction, skin and mucous membrane damage, bone marrow suppression reaction, and decreased white blood cell count (1, 1, 3, 3) in the observation group were smaller than that in the routine group (9, 7, 6, 6). The total incidence of adverse reactions (11.76%) was significantly lower than that of the routine group (41.18%) (P < 0.05) (see Table 5 for details).

Table 5

Comparison of adverse reactions between the two groups (%).

Groups	n	Gastrointestinal reactions	Skin and mucous membrane damage	Myelosuppressive response	Decreased WBC count	Total incidence
Routine group	68	9 (13.24)	7 (10.29)	6 (8.82)	6 (8.82)	28 (41.18)
Observational group	68	1 (1.47)	1 (1.47)	3 (4.41)	3 (4.41)	8 (11.76)
x 2	—	15.111
P	—	<0.001

4. Discussion

Non-small cell lung cancer (NSCLC) is a common malignant lung tumor. In China, it has a high mortality rate, prevalent in middle-aged and elder people. Relevant epidemiological data show that its pathogenesis is closely associated with many factors, such as smoking, occupational exposure and previous chronic lung infection [17]. Currently, chemotherapy is regarded as an effective clinical treatment method [18], which can destroy cancerous cells, yet given its non-selective nature, it can also damage healthy tissues, resulting in a variety of adverse reactions [19]. In addition, lung cancer, a common disease in oncology, inflicts patients with fear, anxiety, and other emotions due to fatigue and cancer pain, which severely undermines their quality of life [20]. If proper care for patients with lung cancer is not provided during chemotherapy, the disease is likely to deteriorate and even results in death, which puts forward higher requirements for the quality of nursing care [21]. In order to alleviate the negative psychological emotions of patients and further improve their quality of life during chemotherapy, it is crucial to implement high-quality nursing care for patients with lung cancer [22] The recent advances in medicine have also updated and improved the nursing model [23]. The high-quality nursing model is newly emerging in the development of modern medical care in China. Combined with health education, it adopts a variety of nursing interventions for patients. A previous study reported that analysis into the evolution of the patient's conditions can positively impact the patient's prognosis [24]. On the basis of previous findings, the current study selected patients diagnosed with NSCLC treated in our hospital as the research objects, aiming to observe and analyze the effect of high-quality nursing intervention combined with health education in chemotherapy for NSCLC and its impact on the physical and mental health of patients.

The study results revealed that after the intervention, the self-management level of patients in the observation group, indicated by the ESCA scores, was significantly higher than that in the routine group. The reason could be that health education can help enhance the patients' sense of identity and awareness of self-management. More targeted and intuitive as it is, high-quality nursing outperforms routine nursing in terms of reducing cancer-related fatigue, improving sleep quality, and enhancing self-care ability [25]. The reason could be that the high-quality nursing intervention was carried out from the aspects of basic nursing, psychological nursing, infusion nursing, and chemotherapy nursing. Basic nursing, mainly including vital sign monitoring, environmental nursing, and skin nursing, aimed to improve the comfort of patients, whereas psychological care is targeted at stabilizing the patients' emotions, helping them build confidence in treatment, and involving them in active cooperation with treatment and nursing care, thereby facilitating the development of various tasks. Infusion care can reduce pain in patients while preventing or relieving phlebitis [26]. Combined with high-quality care, an exclusive nursing plan was tailored in accordance with the patient's conditions to maintain the physical and mental health of the patient and keep the patient with a good awareness and compliance during the long process of chemotherapy. Quality nursing also promotes early recovery and ensures a good prognosis of the patient. The findings of the current study revealed that the clinical efficacy rate (89.71%) in the observation group was significantly higher than that in the routine group (57.35%). The main purpose of chemotherapy nursing was to alleviate adverse reactions, such as gastrointestinal reactions and renal toxicity, that are prone to occur during chemotherapy. At the same time, special care was given to patients with symptoms such as thrombocytopenia and leukopenia, and various nursing measures were strengthened to improve the quality of life of patients and to boost the chemotherapy effect [27].

In this study, GC chemotherapy was comprised of gemcitabine and cisplatin. Gemcitabine is a cytosine drug that can be effective in treating metastatic or locally advanced NSCLC, whereas cisplatin is one of the first-line anticancer drugs with broad-spectrum anticancer activity, which can improve the survival rate of patients. Previous studies suggested that this regimen has positive effects on the treatment of NSCLC. However, in the course of chemotherapy, patients are prone to fatigue, poor mood, etc., and the development of the disease will seriously affect the treatment process. The intervention method of high-quality nursing combined with health education aims to implement a humanized nursing intervention. By providing patients with high-quality nursing services, nursing staff can more comprehensively fulfill nursing responsibilities, extend the connotation of nursing care, and provide patients with nursing care of the best quality. High-quality nursing can improve the patient's sense of satisfaction, security and comfort, with a focus on the psychological care of patients to improve patient compliance and self-confidence [28]. In accordance with earlier findings, it is proposed that high-quality nursing intervention combined with health education during chemotherapy for patients with NSCLC can optimize treatment compliance and confidence, raise the patient's mood, and successfully improve the therapeutic outcomes. This research assessed the patients' physical and emotional well-being following the intervention. After the intervention, the patients' quality of life in the observation group was considerably higher than that in the routine group, evaluated from the aspects of physical function, role function, emotional function, cognitive function, social function, and overall health status. Furthermore, the SAS and SDS scores of the patients in the observation group were lower than those in the routine group, suggesting that the application of high-quality nursing intervention combined with health education in the chemotherapy for NSCLC has a positive impact on the physical and mental health of patients. This is generally attributed to the nursing measures such as health education and psychological intervention carried out by the nursing staff. The nursing staff introduced knowledge on the disease and chemotherapy to the patients, corrected their misunderstandings of chemotherapy, and offered proper psychological counseling to alleviate their negative emotions. Combined with progressive muscle relaxation training, the psychological intervention has further relieved the physical and mental burden of the patient so that the patient could face lung cancer chemotherapy more optimistically and effectively improve their quality of life [29].

The high-quality nursing intervention combined with health education includes physiotherapy, exercise instruction, and lifestyle guidance, on the basis of psychological support. Chemotherapy may induce an energy imbalance and worsen the prognosis in NSCLC patients, which may be related to serotonin disorder, HPA axis disorder, vagus nerve excitation, and rhythm disorder. One of the key explanations is neuroendocrine dysfunction; exercise instruction can effectively intervene in patients. Exercise can strengthen the regulating function of the neuroendocrine system by promoting neurotransmitter activity, neuron excitability, and hormone production. The increased muscular load can enhance sleep quality, thereby improving the patient's quality of life. In addition to offering guidance and paying attention to patients' psychological and emotional changes, timely education and counseling are particular methods for quality improvement. The psychological and physical discomfort of patients can be alleviated through the participation in the therapy and adaptation to daily life activities. The findings and conclusions of related literature (Jinmin Kim et al.) confirmed our conclusion that the application of high-quality nursing intervention combined with health education can effectively improve the physical and mental health of NSCLC patients undergoing chemotherapy. The findings of this study revealed that the total incidence of adverse reactions in the observation group (11.76%) was significantly lower than that in the routine group (41.18%). The reason could be that the nursing staff correctly guided the patients to carry out rehabilitation exercises so as to ensure the patient's whole body in a relaxed state, which was conducive to enhancing the cardiopulmonary function, accelerating the metabolic rate, and improving the sleep of the patient. As patients received psychological and social support from medical staff and community personnel, they were more optimistic to accept their illness, and further improving their quality of life by engaging in more physical activities [30].

Besides, the establishment of a high-quality nursing team can help strengthen health education and psychological intervention, so that patients can fully understand liberation and chemotherapy methods. The highly skilled nursing team will assist in improving patient tolerance, providing intensive preventative care, relieving patient discomfort throughout the treatment process, and addressing adverse responses that take a toll on patients' daily life and treatment. Scholars like Amina and Haiqu have found that exposing NSCLC patients to a diverse nursing model can reduce cancer-related tiredness, increase chemotherapy compliance, and improve nursing satisfaction, which is consistent with the findings of this study.

This study carried out high-quality nursing intervention combined with health education for lung cancer patients undergoing chemotherapy. It has certain guiding significance, yet with the following flaws: the sample size was small, the observation period was short, and no long-term follow-up was performed. Despite the flaws, this method can be applied to the routine care of lung cancer patients undergoing chemotherapy in various medical institutions. It is hoped that future clinical studies based on samples of a larger size will be conducted through the cooperation between researchers and patients, so as to provide more clinical evidence for the research and application of this method.

To sum up, the application of high-quality nursing intervention combined with health education in the chemotherapy for NSCLC effectively improves the patient's compliance and self-management ability. It has a positive impact on the patient's physical and mental health. It reduces the incidence of adverse reactions in patients and provides a more reliable scientific basis for clinical treatment. More extensive research is needed to evaluate the practice and to fully understand the intricacies related to this method.