Background:Recent studies have shown that pregnant women were more likely to experience COVID-19 complications than non-pregnant women, especially during the third trimester. Thus, the objective of the present systematic review is to investigate the literature so as to estimate the safety of COVID-19 vaccination during gestation, regardless of the trimester of pregnancy. Methods: This systematic review was performed based on PRISMA statement and our search included four databases: Medline, PubMed, EMBASE and Google Scholar. Original studies were included. The following search terms were used: coronavirus disease, coronavirus, COVID-19, SARS-CoV-2, vaccine, vaccination, immunity, immunization, pregnancy, gestation, pregnant women, adverse outcomes, impact, safety, risk assessment and all possible combinations between them. Results: The search strategy identified 153 unique items. After the initial screening process, 12 studies underwent full text review and five studies, which met all inclusion criteria, were ultimately included in our systematic review. All four studies claim that COVID-19 vaccination does not have a negative influence on pregnancy and can be beneficial for both the women and their newborns. Conclusion: More clinical trials assessing pregnancy outcome and the value of COVID-19 vaccines in pregnant women are urgently needed. It is vital to determine the most appropriate timing of vaccination across the three trimesters of pregnancy in order to optimize the balance between vaccine efficacy and maternal and foetal safety. Future studies should evaluate the maternal.neonatal transfer of SARS-CoV-2 antibodies as well as long-term infant outcome after administration of the COVID-19 vaccine prenatally.
Background:Recent studies have shown that pregnant women were more likely to experience COVID-19 complications than non-pregnant women, especially during the third trimester. Thus, the objective of the present systematic review is to investigate the literature so as to estimate the safety of COVID-19 vaccination during gestation, regardless of the trimester of pregnancy. Methods: This systematic review was performed based on PRISMA statement and our search included four databases: Medline, PubMed, EMBASE and Google Scholar. Original studies were included. The following search terms were used: coronavirus disease, coronavirus, COVID-19, SARS-CoV-2, vaccine, vaccination, immunity, immunization, pregnancy, gestation, pregnant women, adverse outcomes, impact, safety, risk assessment and all possible combinations between them. Results: The search strategy identified 153 unique items. After the initial screening process, 12 studies underwent full text review and five studies, which met all inclusion criteria, were ultimately included in our systematic review. All four studies claim that COVID-19 vaccination does not have a negative influence on pregnancy and can be beneficial for both the women and their newborns. Conclusion: More clinical trials assessing pregnancy outcome and the value of COVID-19 vaccines in pregnant women are urgently needed. It is vital to determine the most appropriate timing of vaccination across the three trimesters of pregnancy in order to optimize the balance between vaccine efficacy and maternal and foetal safety. Future studies should evaluate the maternal.neonatal transfer of SARS-CoV-2 antibodies as well as long-term infant outcome after administration of the COVID-19 vaccine prenatally.
Authors: Norbert Pardi; Michael J Hogan; Martin S Naradikian; Kaela Parkhouse; Derek W Cain; Letitia Jones; M Anthony Moody; Hans P Verkerke; Arpita Myles; Elinor Willis; Celia C LaBranche; David C Montefiori; Jenna L Lobby; Kevin O Saunders; Hua-Xin Liao; Bette T Korber; Laura L Sutherland; Richard M Scearce; Peter T Hraber; István Tombácz; Hiromi Muramatsu; Houping Ni; Daniel A Balikov; Charles Li; Barbara L Mui; Ying K Tam; Florian Krammer; Katalin Karikó; Patricia Polacino; Laurence C Eisenlohr; Thomas D Madden; Michael J Hope; Mark G Lewis; Kelly K Lee; Shiu-Lok Hu; Scott E Hensley; Michael P Cancro; Barton F Haynes; Drew Weissman Journal: J Exp Med Date: 2018-05-08 Impact factor: 17.579
Authors: Elizabeth Wenqian Wang; Jacqueline G Parchem; Robert L Atmar; Eva H Clark Journal: Open Forum Infect Dis Date: 2021-04-10 Impact factor: 3.835
Authors: Leena B Mithal; Sebastian Otero; Elisheva D Shanes; Jeffery A Goldstein; Emily S Miller Journal: Am J Obstet Gynecol Date: 2021-04-01 Impact factor: 8.661
Authors: Desmond Sutton; Mary D'Alton; Yijia Zhang; Ka Kahe; Ana Cepin; Dena Goffman; Anna Staniczenko; Hope Yates; Anna Burgansky; Jaclyn Coletta; Zev Williams; Cynthia Gyamfi-Bannerman Journal: Am J Obstet Gynecol MFM Date: 2021-05-25
Authors: Miranda J Delahoy; Michael Whitaker; Alissa O'Halloran; Shua J Chai; Pam Daily Kirley; Nisha Alden; Breanna Kawasaki; James Meek; Kimberly Yousey-Hindes; Evan J Anderson; Kyle P Openo; Maya L Monroe; Patricia A Ryan; Kimberly Fox; Sue Kim; Ruth Lynfield; Samantha Siebman; Sarah Shrum Davis; Daniel M Sosin; Grant Barney; Alison Muse; Nancy M Bennett; Christina B Felsen; Laurie M Billing; Jessica Shiltz; Melissa Sutton; Nicole West; William Schaffner; H Keipp Talbot; Andrea George; Melanie Spencer; Sascha Ellington; Romeo R Galang; Suzanne M Gilboa; Van T Tong; Alexandra Piasecki; Lynnette Brammer; Alicia M Fry; Aron J Hall; Jonathan M Wortham; Lindsay Kim; Shikha Garg Journal: MMWR Morb Mortal Wkly Rep Date: 2020-09-25 Impact factor: 17.586