| Literature DB >> 360302 |
E A Higgs, S Moncada, J R Vane.
Abstract
In the rat paw prostacyclin was 5--10 times less potent than PGE2 in causing oedema, and 5 times less potent in potentiating carrageenin-induced oedema, which it did in a dose-related manner. Prostacyclin was 5 times more potent than PGE2 in producing hyperalgesia and as potent as PGE2 in restoring carrageenin-induced hyperalgesia. The effects on oedema were longer lasting than those on hyperalgesia. 6-oxo-PGF1alpha was 500 times less potent than PGE2 in causing oedema by itself and in potentiating carrageenin-induced oedema. It had no hyperalgesic activity in this test.Entities:
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Year: 1978 PMID： 360302 DOI： 10.1016/0090-6980(78)90018-7
Source DB: PubMed Journal: Prostaglandins ISSN： 0090-6980