| Literature DB >> 36010695 |
Jinwoo Lee1, Subin An2,3, Sang-Jin Lee1, Jong-Sun Kang2,3.
Abstract
The authors wish to make the following corrections to this paper [...].Entities:
Year: 2022 PMID: 36010695 PMCID: PMC9406313 DOI: 10.3390/cells11162609
Source DB: PubMed Journal: Cells ISSN: 2073-4409 Impact factor: 7.666
Effect of targeting PRMTs on NMD phenotypes.
| PRMT | Method | Model | Effect on NMD Phenotype |
|---|---|---|---|
| General methyltransferase inhibitor | AdOx | Hela cells | Rescues nuclear import of FUS mutants (R524S, R522G, R525L) [64] |
| General methyltransferase inhibitor | AdOx | Primary rat hippocampal neurons | Rescues nuclear import of FUS mutant (P525L) [64] |
| General methyltransferase inhibitor | AdOx | Primary motor neurons | Diminishes cytoplasmic FUS mutants (R521H, R521G, R521C) [72] |
| General methyltransferase inhibitor | AdOx | ALS patient-derived lymphoblastoid cells | Rescues nuclear import of FUS mutant (R518G) [73] |
| PRMT1 | siRNA KD | Hela cells | Partial rescue of nuclear import of FUS mutant (P525L) [64] |
| PRMT1 | KO | MEF | Diminishes cytoplasmic FUS mutants (R521H, R521G, R521C) [72] |
| PRMT1 | siRNA KD | HEK293 | Diminishes cytoplasmic FUS mutants (R521H, R521G, R521C) [72] |
| PRMT1 | siRNA KD | Primary motor neurons | Increases cytoplasmic FUS mutants (R521H, R521G, R521C) [72] |
| PRMT1 | Inhibitor (AMI-1) | ALS patient-derived lymphoblastoid cells | Rescues nuclear import of FUS mutant (R518G) [73] |
| PRMT1 | shRNA KD | Cortical neurons | Enhances neurite shortening by FUS-R521C under oxidative stress [82] |
| PRMT1 | Overexpression | Cortical neurons | Prevents neurite shortening by FUS-R521C under oxidative stress [82] |
| PRMT1 | Inhibitor (MS023) | NSC-34 | Abrogates PR15-induced toxicity [123] |
| DART1 | siRNA KD | Drosophila | Enhances neurodegeneration of eyes induced by wild-type FUS or FUS-R521H [73] |
| DART1 | siRNA KD | Drosophila | Enhances neurodegeneration of eyes induced by wild-type FUS or FUS-P525L [83] |
| PRMT5 | Inhibitor (CMP5 or HLCL65) | Mouse memory T cells | Suppresses memory T cell expansion [92] |
| PRMT5 | Inhibitor (CMP5) or shRNA KD | Human memory T cells | Suppresses memory T cell activation and expansion, partly through downregulation of IL-2 [92] |
| PRMT5 | Inhibitor (CMP5) | OVA-induced DTH mouse | Suppresses T cell-mediated inflammatory response [92] |
| PRMT5 | Inhibitor (HLCL65) | MOG-induced EAE mouse | Suppresses clinical signs of EAE through diminishing T cell-mediated inflammatory response [92] |
| PRMT5 | CD4+ T-cell specific KO | MOG-induced EAE mouse | Suppresses clinical signs of EAE through diminishing T cell-mediated inflammatory response [95] |
| PRMT6 | Overexpression | MN-1 | Exacerbates cytotoxicity due to polyglutamine-expanded AR [98] |
| DART8 | RNAi KD | Drosophila | Suppresses neurodegenerative phenotype due to polyglutamine-expanded AR [98] |