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Literature DB >> 36001226

KOtBu-catalysed α-homoallylic alkylation of acyclic amides with 1-aryl-1,3-dienes.

Yunfei Xiang¹, Ruisheng Du¹, Shang Wang¹, Xiang Wu¹, Jie Tang¹, Fan Yang², Dong Xing³.

Abstract

Herein, we report a KOtBu-catalysed α-homoallylic alkylation of acyclic amides with 1-aryl-1,3-dienes. With this transition metal-free and atom-economic protocol, a series of α-homoallylic alkylated acyclic amides were synthesized in good to excellent yields. This transformation is proposed to proceed through a cation-π interaction-based C-C bond formation from the in situ-generated potassium enolate with the diene unit.

Entities: Chemical

Keywords: Amide; Diene; Homoallylic alkylation; KOtBu; Transition metal-free

Year: 2022 PMID： 36001226 DOI： 10.1007/s11030-022-10503-8

Source DB: PubMed Journal: Mol Divers ISSN： 1381-1991 Impact factor: 3.364

Keyword Cloud
References

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KOtBu-catalysed α-homoallylic alkylation of acyclic amides with 1-aryl-1,3-dienes.

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