Igor V Ponomarev1, Sergey B Topchiy1, Alexandra E Pushkareva2. 1. P.N. Lebedev Physics Institute, RAS, 53, Leninskiy Prospect, Moscow, 119991, Russian Federation. 2. Saint Petersburg National Research ITMO University; 49, Kronverkskiy Prospect, St. Petersburg, 197101, Russian Federation.
Abstract
Introduction: Many clinical studies and protocols have been written about laser treatment for fair skin phototypes. However, for dark-skinned phototypes, information is limited, and the risk of burns is higher, especially if the same settings are recommended for fair skin. Competitive epidermal melanin absorption decreases the light energy reaching dysplastic vessels in a port-wine stain (PWS), preventing the vessel from achieving the temperature of the desired clinical result. Therefore, the choice of safe laser settings for different skin phototypes can be realized using numerical modeling of PWS vessel heating. This study aimed to demonstrate the algorithm for choosing both effective and safe photodestruction of dilated dermal vessels in PWS with the copper vapor laser (CVL) at 578 nm for different skin phototypes. Methods: We used the multilayered skin model with different melanin content for detecting the safe laser parameters for PWS treatment. The calculation of the selective heating of the vascular component with CVL radiation at yellow 578-nm wavelengths for different skin phototypes was performed via Matlab mathematical programming system and its application Femlab for solving partial differential equations using the Finite element method. Results: We determined the location, depth, and size of blood vessels that could be selectively heated to coagulation temperature for different skin prototypes. CVL fluence values need to be reduced almost two times for skin phototype IV than for skin phototype II to provide safe CVL treatment. The maximum depth of the location of the vessels, which can be selectively heated to coagulation temperature, also decreased for dark skin phototypes. Histological and histochemical findings validated the results of our calculations. Conclusion: To our knowledge, the use of numerical simulation to optimize has not yet been considered. According to our calculations, CVL could selectively heat the dilated vessel, which occurred in purple and proliferative-type PWS for dark skin at the reduced fluence range and depth.
Introduction: Many clinical studies and protocols have been written about laser treatment for fair skin phototypes. However, for dark-skinned phototypes, information is limited, and the risk of burns is higher, especially if the same settings are recommended for fair skin. Competitive epidermal melanin absorption decreases the light energy reaching dysplastic vessels in a port-wine stain (PWS), preventing the vessel from achieving the temperature of the desired clinical result. Therefore, the choice of safe laser settings for different skin phototypes can be realized using numerical modeling of PWS vessel heating. This study aimed to demonstrate the algorithm for choosing both effective and safe photodestruction of dilated dermal vessels in PWS with the copper vapor laser (CVL) at 578 nm for different skin phototypes. Methods: We used the multilayered skin model with different melanin content for detecting the safe laser parameters for PWS treatment. The calculation of the selective heating of the vascular component with CVL radiation at yellow 578-nm wavelengths for different skin phototypes was performed via Matlab mathematical programming system and its application Femlab for solving partial differential equations using the Finite element method. Results: We determined the location, depth, and size of blood vessels that could be selectively heated to coagulation temperature for different skin prototypes. CVL fluence values need to be reduced almost two times for skin phototype IV than for skin phototype II to provide safe CVL treatment. The maximum depth of the location of the vessels, which can be selectively heated to coagulation temperature, also decreased for dark skin phototypes. Histological and histochemical findings validated the results of our calculations. Conclusion: To our knowledge, the use of numerical simulation to optimize has not yet been considered. According to our calculations, CVL could selectively heat the dilated vessel, which occurred in purple and proliferative-type PWS for dark skin at the reduced fluence range and depth.