[Non-invasive secretory carcinoma of the breast].

A case of non-invasive secretory carcinoma of the breast is reported. The patient was a 33-year-old Japanese woman who complained of abnormal nipple discharge from the right breast. Although physical and radiological examinations failed to find any abnormal nodular lesions in the breast, a cytological examination revealed signet-ring-like atypical cells in the smears of nipple discharge. Radical mastectomy with axillary lymph nodes dissection was performed. No nodular lesions were macroscopically observed. However, intraductal proliferation of atypical cells was microscopically found in the excised breast. Diastase-resistant PAS-positive mucus was observed in the tumor-cell-forming-lumina and in the cytoplasm of tumor cells. No metastases were observed in the axillary lymph nodes.