| Literature DB >> 35994369 |
Kindi Farabi1,2, Desi Harneti1,3, Tri Mayanti1,3, Rani Maharani1,3, Unang Supratman1,2, Sofa Fajriah4, Hadi Kuncoro5, Mohamad Nurul Azmi6, Yoshihito Shiono7.
Abstract
Three new dammarane-type triterpenoids, namely elliptaglin A-C (1-3) were isolated from the stem bark of Aglaia elliptica (C.DC.) Blume along with three known derivatives, namely (20S)-hydroxydammar-24-en-3-on (4), cabralealactone (5), and E-25-hydroperoxydammar-23-en-20-ol-3-one (6). Subsequently, their chemical structures were determined using HR-ESI-MS, FTIR, 1D and 2D-NMR spectroscopic analysis as well as comparison with previous studies. The cytotoxicity activities of the isolated compounds against MCF-7 breast cancer and B16-F10 melanoma cell lines were then tested using PrestoBlue reagent. The analysis results showed that elliptaglin B (2) had the strongest activity against both cell lines with IC50 values of 60.98 and 51.83 µM, respectively.Entities:
Keywords: Aglaia elliptica; Meliaceae; cytotoxic activities; dammarane-type triterpenoids; elliptaglin A-C
Year: 2022 PMID： 35994369 DOI： 10.1080/14786419.2022.2114472
Source DB: PubMed Journal: Nat Prod Res ISSN： 1478-6419 Impact factor: 2.488