Daniel Iluz-Freundlich1, Julia Uhanova1, Gerald Y Minuk1,2. 1. Section of Hepatology, Department of Medicine, and. 2. Department of Pharmacology and Therapeutics, College of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.
Abstract
BACKGROUND: Seasonal variations in flu-like illnesses and vaccinations, vitamin D levels, alcohol intake, and sedentary lifestyles raise the possibility that seasonal variations exist in the severity of immune-mediated, alcohol, and obesity- or dyslipidemia-related chronic liver diseases, respectively. METHODS: We documented months-seasons in which biochemical evidence of disease activity is greatest in adult patients with common liver disorders. Months-seasons associated with peak liver enzyme levels in patients with largely immune-mediated disorders (autoimmune hepatitis, primary biliary cholangitis [PBC], and primary sclerosing cholangitis), alcoholic liver disease, and non-alcoholic fatty liver disease were documented from a hospital-based, liver diseases outpatient clinic database. RESULTS: Aside from a spike in the severity of PBC during July (p < .005), no significant associations were found between months-seasons and peak liver enzyme activities in any of these liver disorders. CONCLUSIONS: These findings suggest that seasonal illnesses or immunizations and vitamin D depletion, alcohol intake, and sedentary lifestyle do not significantly exacerbate common underlying immune-mediated, alcohol, or metabolic liver disorders, respectively.
BACKGROUND: Seasonal variations in flu-like illnesses and vaccinations, vitamin D levels, alcohol intake, and sedentary lifestyles raise the possibility that seasonal variations exist in the severity of immune-mediated, alcohol, and obesity- or dyslipidemia-related chronic liver diseases, respectively. METHODS: We documented months-seasons in which biochemical evidence of disease activity is greatest in adult patients with common liver disorders. Months-seasons associated with peak liver enzyme levels in patients with largely immune-mediated disorders (autoimmune hepatitis, primary biliary cholangitis [PBC], and primary sclerosing cholangitis), alcoholic liver disease, and non-alcoholic fatty liver disease were documented from a hospital-based, liver diseases outpatient clinic database. RESULTS: Aside from a spike in the severity of PBC during July (p < .005), no significant associations were found between months-seasons and peak liver enzyme activities in any of these liver disorders. CONCLUSIONS: These findings suggest that seasonal illnesses or immunizations and vitamin D depletion, alcohol intake, and sedentary lifestyle do not significantly exacerbate common underlying immune-mediated, alcohol, or metabolic liver disorders, respectively.
Authors: John E Eaton; Jayant A Talwalkar; Konstantinos N Lazaridis; Gregory J Gores; Keith D Lindor Journal: Gastroenterology Date: 2013-07-01 Impact factor: 22.682
Authors: Ira S Ockene; David E Chiriboga; Edward J Stanek; Morton G Harmatz; Robert Nicolosi; Gordon Saperia; Arnold D Well; Patty Freedson; Philip A Merriam; George Reed; Yunsheng Ma; Charles E Matthews; James R Hebert Journal: Arch Intern Med Date: 2004-04-26