Literature DB >> 35992625

Revisiting the '6-month' liver transplant rule for alcohol-associated liver disease: It is time for a change but not without a sound policy first.

Sanjeev Sirpal1, Eric M Yoshida2, Natasha Chandok3.   

Abstract

There is historical reluctance in the medical community to offer liver transplantation to patients with alcoholic liver disease. Transplant programs broadly follow a policy that requires abstention from alcohol for a minimum of 6 months. This policy, however, is at odds with data that supports improved survival in patients with severe acute alcoholic hepatitis (SAAH). Ethicists, the public, and the transplant community must make a concerted effort to forge an updated transplant policy for SAAH that better reflects current scientific evidence for earlier transplant in well-selected recipients without unfair advantage to those of high socioeconomic status.
Copyright © 2018 Canadian Association for the Study of the Liver.

Entities:  

Keywords:  alcoholic cirrhosis; alcoholic hepatitis; organ recipient; organ transplantation; policy

Year:  2018        PMID: 35992625      PMCID: PMC9202758          DOI: 10.3138/canlivj.2018-0002

Source DB:  PubMed          Journal:  Can Liver J        ISSN: 2561-4444


  10 in total

1.  Early liver transplantation for severe alcoholic hepatitis.

Authors:  Philippe Mathurin; Christophe Moreno; Didier Samuel; Jérôme Dumortier; Julia Salleron; François Durand; Hélène Castel; Alain Duhamel; Georges-Philippe Pageaux; Vincent Leroy; Sébastien Dharancy; Alexandre Louvet; Emmanuel Boleslawski; Valerio Lucidi; Thierry Gustot; Claire Francoz; Christian Letoublon; Denis Castaing; Jacques Belghiti; Vincent Donckier; François-René Pruvot; Jean-Charles Duclos-Vallée
Journal:  N Engl J Med       Date:  2011-11-10       Impact factor: 91.245

2.  Survival gain after liver transplantation for patients with alcoholic liver disease: a comparison across models and centers.

Authors:  Tracey A Young; James Neuberger; Louise Longworth; Julie Ratcliffe; Martin J Buxton
Journal:  Transplantation       Date:  2003-11-27       Impact factor: 4.939

Review 3.  Liver transplantation in patients with alcoholic liver disease.

Authors:  Michael R Lucey
Journal:  Liver Transpl       Date:  2011-07       Impact factor: 5.799

4.  Liver transplantation for alcoholic cirrhosis: long term follow-up and impact of disease recurrence.

Authors:  C O Bellamy; A M DiMartini; K Ruppert; A Jain; F Dodson; M Torbenson; T E Starzl; J J Fung; A J Demetris
Journal:  Transplantation       Date:  2001-08-27       Impact factor: 4.939

Review 5.  Acute alcoholic hepatitis, end stage alcoholic liver disease and liver transplantation: an Italian position statement.

Authors:  Gianni Testino; Patrizia Burra; Ferruccio Bonino; Francesco Piani; Alessandro Sumberaz; Roberto Peressutti; Andrea Giannelli Castiglione; Valentino Patussi; Tiziana Fanucchi; Ornella Ancarani; Giovanna De Cerce; Anna Teresa Iannini; Giovanni Greco; Antonio Mosti; Marilena Durante; Paola Babocci; Mariano Quartini; Davide Mioni; Sarino Aricò; Aniello Baselice; Silvia Leone; Fabiola Lozer; Emanuele Scafato; Paolo Borro
Journal:  World J Gastroenterol       Date:  2014-10-28       Impact factor: 5.742

6.  Are preoperative patterns of alcohol consumption predictive of relapse after liver transplantation for alcoholic liver disease?

Authors:  Pascal Perney; Michaël Bismuth; Hélène Sigaud; Marie Christine Picot; Eric Jacquet; Pierre Puche; Samir Jaber; Hélène Rigole; Françis Navarro; Jean-Jacques Eledjam; François Blanc; Dominique Larrey; Georges-Philippe Pageaux
Journal:  Transpl Int       Date:  2005-11       Impact factor: 3.782

7.  Liver transplantation for alcoholic liver disease among Canadian transplant centres: a national study.

Authors:  Natasha Chandok; Mohammed Aljawad; Angela White; Roberto Hernandez-Alejandro; Paul Marotta; Eric M Yoshida
Journal:  Can J Gastroenterol       Date:  2013-09-13       Impact factor: 3.522

Review 8.  Artificial liver support systems in the management of complications of cirrhosis.

Authors:  Vanessa Stadlbauer; Nathan A Davies; Sambit Sen; Rajiv Jalan
Journal:  Semin Liver Dis       Date:  2008-02       Impact factor: 6.115

9.  Liver transplantation for alcoholic liver disease: a retrospective analysis of recidivism, survival and risk factors predisposing to alcohol relapse.

Authors:  Elise Deruytter; Christophe Van Steenkiste; Eric Trépo; Anja Geerts; Hans Van Vlierberghe; Frederik Berrevoet; Bernard de Hemptinne; Xavier Rogiers; Roberto Troisi; Isabelle Colle
Journal:  Acta Gastroenterol Belg       Date:  2013-09       Impact factor: 1.316

10.  Change in model for end-stage liver disease score at two weeks, as an indicator of mortality or liver transplantation at 60 days in acute-on-chronic liver failure.

Authors:  Rajneesh Kumar; Thinesh Lee Krishnamoorthy; Hiang Keat Tan; Hock Foong Lui; Wan Cheng Chow
Journal:  Gastroenterol Rep (Oxf)       Date:  2014-11-11
  10 in total

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