Literature DB >> 35991712

Effect on SARS-CoV-2 viral load using combination therapy with casirivimab/imdevimab and remdesivir.

Vivek K Kataria1, Mezgebe Berhe2, Uriel Sandkovsky2.   

Abstract

Evidence suggests that SARS-CoV-2 viral load is an independent predictor of disease severity and mortality. A 61-year-old woman presented with severe COVID-19 and was treated with casirivimab/imdevimab and remdesivir. Quantitative nasopharyngeal (NP) viral loads were trended throughout the treatment course. Baseline NP viral load was 25,860,901 copies/mL (7.4 log10). Casirivimab/imdevimab was administered, with subsequent reduction in NP viral load to 26,049 copies/mL (4.4 log10) on hospital day 4. A repeat NP viral load on day 7 was 13,113 copies/mL (4.1 log10). Despite uncertainty regarding correlation with reduction in viral load and outcomes, NP viral load may be considered when selecting treatment options and evaluating treatment response in hospitalized patients with early infection.
Copyright © 2022 Baylor University Medical Center.

Entities:  

Keywords:  COVID; anti-infectives; infectious diseases

Year:  2022        PMID： 35991712      PMCID： PMC9373739          DOI： 10.1080/08998280.2022.2075676

Source DB:  PubMed          Journal:  Proc (Bayl Univ Med Cent)        ISSN： 0899-8280


  12 in total

1.  Infectious Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Virus in Symptomatic Coronavirus Disease 2019 (COVID-19) Outpatients: Host, Disease, and Viral Correlates.

Authors:  Katie R Mollan; Joseph J Eron; Taylor J Krajewski; Wendy Painter; Elizabeth R Duke; Caryn G Morse; Erin A Goecker; Lakshmanane Premkumar; Cameron R Wolfe; Laura J Szewczyk; Paul L Alabanza; Amy James Loftis; Emily J Degli-Angeli; Ariane J Brown; Joan A Dragavon; John J Won; Jessica Keys; Michael G Hudgens; Lei Fang; David A Wohl; Myron S Cohen; Ralph S Baric; Robert W Coombs; Timothy P Sheahan; William A Fischer
Journal:  Clin Infect Dis       Date:  2022-08-24       Impact factor: 20.999

2.  Association Between mRNA Vaccination and COVID-19 Hospitalization and Disease Severity.

Authors:  Mark W Tenforde; Wesley H Self; Katherine Adams; Manjusha Gaglani; Adit A Ginde; Tresa McNeal; Shekhar Ghamande; David J Douin; H Keipp Talbot; Jonathan D Casey; Nicholas M Mohr; Anne Zepeski; Nathan I Shapiro; Kevin W Gibbs; D Clark Files; David N Hager; Arber Shehu; Matthew E Prekker; Heidi L Erickson; Matthew C Exline; Michelle N Gong; Amira Mohamed; Daniel J Henning; Jay S Steingrub; Ithan D Peltan; Samuel M Brown; Emily T Martin; Arnold S Monto; Akram Khan; Catherine L Hough; Laurence W Busse; Caitlin C Ten Lohuis; Abhijit Duggal; Jennifer G Wilson; Alexandra June Gordon; Nida Qadir; Steven Y Chang; Christopher Mallow; Carolina Rivas; Hilary M Babcock; Jennie H Kwon; Natasha Halasa; James D Chappell; Adam S Lauring; Carlos G Grijalva; Todd W Rice; Ian D Jones; William B Stubblefield; Adrienne Baughman; Kelsey N Womack; Jillian P Rhoads; Christopher J Lindsell; Kimberly W Hart; Yuwei Zhu; Samantha M Olson; Miwako Kobayashi; Jennifer R Verani; Manish M Patel
Journal:  JAMA       Date:  2021-11-23       Impact factor: 157.335

3.  Responses to a Neutralizing Monoclonal Antibody for Hospitalized Patients With COVID-19 According to Baseline Antibody and Antigen Levels : A Randomized Controlled Trial.

Authors:  Jens D Lundgren; Birgit Grund; Christina E Barkauskas; Thomas L Holland; Robert L Gottlieb; Uriel Sandkovsky; Samuel M Brown; Kirk U Knowlton; Wesley H Self; D Clark Files; Mamta K Jain; Thomas Benfield; Michael E Bowdish; Bradley G Leshnower; Jason V Baker; Jens-Ulrik Jensen; Edward M Gardner; Adit A Ginde; Estelle S Harris; Isik S Johansen; Norman Markowitz; Michael A Matthay; Lars Østergaard; Christina C Chang; Anna L Goodman; Weizhong Chang; Robin L Dewar; Norman P Gerry; Elizabeth S Higgs; Helene Highbarger; Daniel D Murray; Thomas A Murray; Ven Natarajan; Roger Paredes; Mahesh K B Parmar; Andrew N Phillips; Cavan Reilly; Adam W Rupert; Shweta Sharma; Kathryn Shaw-Saliba; Brad T Sherman; Marc Teitelbaum; Deborah Wentworth; Huyen Cao; Paul Klekotka; Abdel G Babiker; Victoria J Davey; Annetine C Gelijns; Virginia L Kan; Mark N Polizzotto; B Taylor Thompson; H Clifford Lane; James D Neaton
Journal:  Ann Intern Med       Date:  2021-12-21       Impact factor: 51.598

4.  Surviving Sepsis Campaign Guidelines on the Management of Adults With Coronavirus Disease 2019 (COVID-19) in the ICU: First Update.

Authors:  Waleed Alhazzani; Laura Evans; Fayez Alshamsi; Morten Hylander Møller; Marlies Ostermann; Hallie C Prescott; Yaseen M Arabi; Mark Loeb; Michelle Ng Gong; Eddy Fan; Simon Oczkowski; Mitchell M Levy; Lennie Derde; Amy Dzierba; Bin Du; Flavia Machado; Hannah Wunsch; Mark Crowther; Maurizio Cecconi; Younsuck Koh; Lisa Burry; Daniel S Chertow; Wojciech Szczeklik; Emilie Belley-Cote; Massimiliano Greco; Malgorzata Bala; Ryan Zarychanski; Jozef Kesecioglu; Allison McGeer; Leonard Mermel; Manoj J Mammen; Sheila Nainan Myatra; Amy Arrington; Ruth Kleinpell; Giuseppe Citerio; Kimberley Lewis; Elizabeth Bridges; Ziad A Memish; Naomi Hammond; Frederick G Hayden; Muhammed Alshahrani; Zainab Al Duhailib; Greg S Martin; Lewis J Kaplan; Craig M Coopersmith; Massimo Antonelli; Andrew Rhodes
Journal:  Crit Care Med       Date:  2021-03-01       Impact factor: 7.598

5.  REGN-COV2, a Neutralizing Antibody Cocktail, in Outpatients with Covid-19.

Authors:  David M Weinreich; Sumathi Sivapalasingam; Thomas Norton; Shazia Ali; Haitao Gao; Rafia Bhore; Bret J Musser; Yuhwen Soo; Diana Rofail; Joseph Im; Christina Perry; Cynthia Pan; Romana Hosain; Adnan Mahmood; John D Davis; Kenneth C Turner; Andrea T Hooper; Jennifer D Hamilton; Alina Baum; Christos A Kyratsous; Yunji Kim; Amanda Cook; Wendy Kampman; Anita Kohli; Yessica Sachdeva; Ximena Graber; Bari Kowal; Thomas DiCioccio; Neil Stahl; Leah Lipsich; Ned Braunstein; Gary Herman; George D Yancopoulos
Journal:  N Engl J Med       Date:  2020-12-17       Impact factor: 91.245

6.  Early Remdesivir to Prevent Progression to Severe Covid-19 in Outpatients.

Authors:  Robert L Gottlieb; Carlos E Vaca; Roger Paredes; Jorge Mera; Brandon J Webb; Gilberto Perez; Godson Oguchi; Pablo Ryan; Bibi U Nielsen; Michael Brown; Ausberto Hidalgo; Yessica Sachdeva; Shilpi Mittal; Olayemi Osiyemi; Jacek Skarbinski; Kavita Juneja; Robert H Hyland; Anu Osinusi; Shuguang Chen; Gregory Camus; Mazin Abdelghany; Santosh Davies; Nicole Behenna-Renton; Frank Duff; Francisco M Marty; Morgan J Katz; Adit A Ginde; Samuel M Brown; Joshua T Schiffer; Joshua A Hill
Journal:  N Engl J Med       Date:  2021-12-22       Impact factor: 91.245

7.  The Omicron variant is highly resistant against antibody-mediated neutralization: Implications for control of the COVID-19 pandemic.

Authors:  Markus Hoffmann; Nadine Krüger; Sebastian Schulz; Anne Cossmann; Cheila Rocha; Amy Kempf; Inga Nehlmeier; Luise Graichen; Anna-Sophie Moldenhauer; Martin S Winkler; Martin Lier; Alexandra Dopfer-Jablonka; Hans-Martin Jäck; Georg M N Behrens; Stefan Pöhlmann
Journal:  Cell       Date:  2021-12-24       Impact factor: 41.582

8.  REGEN-COV Antibody Combination and Outcomes in Outpatients with Covid-19.

Authors:  David M Weinreich; Sumathi Sivapalasingam; Thomas Norton; Shazia Ali; Haitao Gao; Rafia Bhore; Jing Xiao; Andrea T Hooper; Jennifer D Hamilton; Bret J Musser; Diana Rofail; Mohamed Hussein; Joseph Im; Dominique Y Atmodjo; Christina Perry; Cynthia Pan; Adnan Mahmood; Romana Hosain; John D Davis; Kenneth C Turner; Alina Baum; Christos A Kyratsous; Yunji Kim; Amanda Cook; Wendy Kampman; Lilia Roque-Guerrero; Gerard Acloque; Hessam Aazami; Kevin Cannon; J Abraham Simón-Campos; Joseph A Bocchini; Bari Kowal; A Thomas DiCioccio; Yuhwen Soo; Gregory P Geba; Neil Stahl; Leah Lipsich; Ned Braunstein; Gary Herman; George D Yancopoulos
Journal:  N Engl J Med       Date:  2021-09-29       Impact factor: 176.079

9.  Casirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.

Authors: 
Journal:  Lancet       Date:  2022-02-12       Impact factor: 79.321

Review 10.  Remdesivir and its antiviral activity against COVID-19: A systematic review.

Authors:  Andri Frediansyah; Firzan Nainu; Kuldeep Dhama; Mudatsir Mudatsir; Harapan Harapan
Journal:  Clin Epidemiol Glob Health       Date:  2020-08-07
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  1 in total

1.  Lessons learned and implications of early therapies for coronavirus disease in a territorial service centre in the Calabria region: a retrospective study.

Authors:  Vincenzo Scaglione; Salvatore Rotundo; Nadia Marascio; Carmela De Marco; Rosaria Lionello; Claudia Veneziano; Lavinia Berardelli; Angela Quirino; Vincenzo Olivadese; Francesca Serapide; Bruno Tassone; Helen Linda Morrone; Chiara Davoli; Valentina La Gamba; Andrea Bruni; Bruno Mario Cesana; Giovanni Matera; Alessandro Russo; Francesco Saverio Costanzo; Giuseppe Viglietto; Enrico Maria Trecarichi; Carlo Torti
Journal:  BMC Infect Dis       Date:  2022-10-20       Impact factor: 3.667
  1 in total

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