Literature DB >> 35990718

6th Canadian Symposium on Hepatitis C Virus: Delivering a cure for hepatitis C infection-What are the remaining gaps?

Sarwat Khan1,2, Annie Bernier3, Dustin Dapp4, Emmanuel Fortier5, Mel Krajden6, Alexandra King7, Jason Grebely8, Selena M Sagan3, Curtis L Cooper9,10, Angela M Crawley1,11,12.   

Abstract

Estimates are that more than 250,000 people in Canada are chronically infected with hepatitis C virus (HCV), and many more are unaware of their infection status. If untreated, chronic HCV infection can lead to cirrhosis and subsequent complications such as hepatocellular carcinoma. The Canadian Network on Hepatitis C, supported by the Public Health Agency of Canada and the Canadian Institutes of Health Research, has been committed to the scientific study of chronic hepatitis C and to supporting the advocacy work to improve diagnosis and access to HCV care in Canada. Although the treatment of HCV infection has been greatly advanced with direct-acting antivirals, with cure rates as high as 95%, many challenges remain in the implementation of HCV care. These issues include the lack of an effective vaccine, infection screening, treatment failure or resistance, post-cure health issues, limitations of treatment access despite increased provincial subsidization, complex needs of at-risk populations (ie, injection drug users, societal obstacles). At the 6th Canadian Symposium on HCV in March 2017, the theme "Delivering a Cure for Hepatitis C Infection: What Are the Remaining Gaps?" provided a framework in which basic scientists, clinicians, epidemiologists, social scientists, and community members interested in HCV research in Canada could showcase how they are working to address these ongoing challenges.
Copyright © 2018 Canadian Association for the Study of the Liver.

Entities:  

Keywords:  CanHepC; HCV; host–virus interactions; sustained virologic response (SVR)

Year:  2018        PMID: 35990718      PMCID: PMC9202794          DOI: 10.3138/canlivj.1.2.008

Source DB:  PubMed          Journal:  Can Liver J        ISSN: 2561-4444


  57 in total

1.  Safer injection facility use and syringe sharing in injection drug users.

Authors:  Thomas Kerr; Mark Tyndall; Kathy Li; Julio Montaner; Evan Wood
Journal:  Lancet       Date:  2005 Jul 23-29       Impact factor: 79.321

Review 2.  National treatment programme of hepatitis C in Egypt: Hepatitis C virus model of care.

Authors:  W El-Akel; M H El-Sayed; M El Kassas; M El-Serafy; M Khairy; K Elsaeed; K Kabil; M Hassany; A Shawky; A Yosry; M K Shaker; Y ElShazly; I Waked; G Esmat; W Doss
Journal:  J Viral Hepat       Date:  2017-02-01       Impact factor: 3.728

3.  Liver enzyme normalization predicts success of Hepatitis C oral direct-acting antiviral treatment.

Authors:  Sarwat T Khan; Michaeline McGuinty; Daniel J Corsi; Curtis L Cooper
Journal:  Clin Invest Med       Date:  2017-04-26       Impact factor: 0.825

4.  Neutrophil extracellular traps mediate a host defense response to human immunodeficiency virus-1.

Authors:  Tatsuya Saitoh; Jun Komano; Yasunori Saitoh; Takuma Misawa; Michihiro Takahama; Tatsuya Kozaki; Takuya Uehata; Hidenori Iwasaki; Hiroko Omori; Shoji Yamaoka; Naoki Yamamoto; Shizuo Akira
Journal:  Cell Host Microbe       Date:  2012-07-19       Impact factor: 21.023

5.  An update on the management of chronic hepatitis C: 2015 Consensus guidelines from the Canadian Association for the Study of the Liver.

Authors:  Robert P Myers; Hemant Shah; Kelly W Burak; Curtis Cooper; Jordan J Feld
Journal:  Can J Gastroenterol Hepatol       Date:  2015-01-13

Review 6.  From non-A, non-B hepatitis to hepatitis C virus cure.

Authors:  Jean-Michel Pawlotsky; Jordan J Feld; Stefan Zeuzem; Jay H Hoofnagle
Journal:  J Hepatol       Date:  2015-04       Impact factor: 25.083

7.  Opioid substitution therapy protects against hepatitis C virus acquisition in people who inject drugs: the HITS-c study.

Authors:  Bethany White; Gregory J Dore; Andrew R Lloyd; William D Rawlinson; Lisa Maher
Journal:  Med J Aust       Date:  2014-09-15       Impact factor: 7.738

8.  Molecular mechanisms of NET formation and degradation revealed by intravital imaging in the liver vasculature.

Authors:  Elzbieta Kolaczkowska; Craig N Jenne; Bas G J Surewaard; Ajitha Thanabalasuriar; Woo-Yong Lee; Maria-Jesus Sanz; Kerri Mowen; Ghislain Opdenakker; Paul Kubes
Journal:  Nat Commun       Date:  2015-03-26       Impact factor: 14.919

9.  Sofosbuvir and Velpatasvir for HCV in Patients with Decompensated Cirrhosis.

Authors:  Michael P Curry; Jacqueline G O'Leary; Natalie Bzowej; Andrew J Muir; Kevin M Korenblat; Jonathan M Fenkel; K Rajender Reddy; Eric Lawitz; Steven L Flamm; Thomas Schiano; Lewis Teperman; Robert Fontana; Eugene Schiff; Michael Fried; Brian Doehle; Di An; John McNally; Anu Osinusi; Diana M Brainard; John G McHutchison; Robert S Brown; Michael Charlton
Journal:  N Engl J Med       Date:  2015-11-16       Impact factor: 91.245

Review 10.  The Seroprevalence of Hepatitis C Antibodies in Immigrants and Refugees from Intermediate and High Endemic Countries: A Systematic Review and Meta-Analysis.

Authors:  Christina Greenaway; Ann Thu Ma; Lorie A Kloda; Marina Klein; Sonya Cnossen; Guido Schwarzer; Ian Shrier
Journal:  PLoS One       Date:  2015-11-11       Impact factor: 3.240

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